Lipopolysaccharide Preconditioning Augments Phagocytosis of Malaria-Parasitized Red Blood Cells by Bone Marrow-Derived Macrophages in the Liver, Thereby Increasing the Murine Survival after Plasmodium yoelii Infection

Malaria remains a grave concern for humans, as effective medical countermeasures for infection have yet to be developed. Phagocytic clearance of parasitized red blood cells (pRBCs) by macrophages is an important front-line innate host defense against infection. We previously showed that repeated inj...

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Veröffentlicht in:	Infection and immunity 2021-10, Vol.89 (11), p.e0024921-e0024921
Hauptverfasser:	Ono, Takeshi, Yamaguchi, Yoko, Nakashima, Hiroyuki, Nakashima, Masahiro, Ishikiriyama, Takuya, Seki, Shuhji, Kinoshita, Manabu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Erythrocytes - parasitology Host Response and Inflammation Immunology Lipopolysaccharides - pharmacology Liver - immunology Macrophages - immunology Malaria - immunology Male Mice Mice, Inbred C57BL Phagocytosis - drug effects Plasmodium yoelii - growth & development Tumor Necrosis Factor-alpha - blood
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