Mismatch repair deficiency is rare in bone and soft tissue tumors

Introduction There has been an increased demand for mismatch repair (MMR) status testing in sarcoma patients after the success of immune checkpoint inhibition (ICI) in MMR deficient tumors. However, data on MMR deficiency in bone and soft tissue tumors is sparse, rendering it unclear if routine scre...

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Veröffentlicht in:	Histopathology 2021-10, Vol.79 (4), p.509-520
Hauptverfasser:	Lam, Suk Wai, Kostine, Marie, Miranda, Noel F C C, Schöffski, Patrick, Lee, Che‐Jui, Morreau, Hans, Bovée, Judith V M G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers, Tumor - analysis bone and soft tissue tumors Bone Neoplasms Bone tumors Brain Neoplasms Colorectal Neoplasms DNA-Binding Proteins - analysis DNA-Binding Proteins - metabolism Humans Immune checkpoint inhibitors immunohistochemistry Literature reviews Male Microsatellite instability Middle Aged Mismatch repair mismatch repair deficiency Mismatch Repair Endonuclease PMS2 - analysis Mismatch Repair Endonuclease PMS2 - metabolism MLH1 protein MSH2 protein MSH6 protein MutL Protein Homolog 1 - analysis MutL Protein Homolog 1 - metabolism MutS Homolog 2 Protein - analysis MutS Homolog 2 Protein - metabolism Neoplastic Syndromes, Hereditary Original Peripheral nerves Rhabdomyosarcoma Sarcoma Soft Tissue Neoplasms Tumors
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