Impaired myelin production due to an intrinsic failure of oligodendrocytes in mTORpathies

Aims We aim to evaluate if the myelin pathology observed in epilepsy‐associated focal cortical dysplasia type 2B (FCD2B) and—histologically indistinguishable—cortical tubers of tuberous sclerosis complex (TSC) is primarily related to the underlying malformation or constitutes a secondary phenomenon...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2021-10, Vol.47 (6), p.812-825
Hauptverfasser:	Gruber, Victoria‐Elisabeth, Lang, Judith, Endmayr, Verena, Diehm, Robert, Pimpel, Birgit, Glatter, Sarah, Anink, Jasper J., Bongaarts, Anika, Luinenburg, Mark J., Reinten, Roy J., Wel, Nicole, Larsen, Per, Hainfellner, Johannes A., Rössler, Karl, Aronica, Eleonora, Scholl, Theresa, Mühlebner, Angelika, Feucht, Martha
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - growth & development Brain - pathology Cell culture Child Child, Preschool Dysplasia Electron microscopy Epilepsy Epilepsy - metabolism Epilepsy - pathology Female focal cortical dysplasia 2B Humans Immunofluorescence Infant Inflammation Male Malformations of Cortical Development - complications Malformations of Cortical Development, Group I - metabolism Microenvironments Myelin Sheath - metabolism Myelin Sheath - pathology Myelination nanofibres oligodendrocyte Oligodendrocytes Oligodendroglia - metabolism Oligodendroglia - pathology Original Pathology Patients Polycaprolactone Seizures Substantia alba TOR protein TOR Serine-Threonine Kinases - metabolism Tuberous sclerosis Tuberous Sclerosis - complications Tuberous Sclerosis - metabolism Tuberous Sclerosis - pathology tuberous sclerosis complex Tuberous Sclerosis Complex 2
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