Loss‐of‐Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia

Background and Aims Hypoxia is a common feature of the tumor microenvironment (TME), which promotes tumor progression, metastasis, and therapeutic drug resistance through a myriad of cell activities in tumor and stroma cells. While targeting hypoxic TME is emerging as a promising strategy for treati...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2021-09, Vol.74 (3), p.1461-1479
Hauptverfasser:	Niu, Yi, Lin, Ziyou, Wan, Arabella, Sun, Lei, Yan, Shijia, Liang, Heng, Zhan, Siyue, Chen, Dongshi, Bu, Xianzhang, Liu, Peiqing, Chen, Ceshi, He, Weiling, Lu, Xiongbin, Wan, Guohui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism Animals Antitumor activity Body fat Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell growth Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics CRISPR Drug resistance Fructose-Bisphosphate Aldolase - genetics Fructose-Bisphosphate Aldolase - metabolism Gene Knockdown Techniques Gene regulation Genetic screening Genomes Gluconeogenesis Glycolysis Hep G2 Cells Hepatocytes Hepatology Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Lactic acid Lactic Acid - metabolism Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Loss of Function Mutation Metastases Mice N6-methyladenosine Neoplasm Transplantation Original Patients Post-transcription Solid tumors Stroma Sulfamonomethoxine Sulfamonomethoxine - analogs & derivatives Tumor Hypoxia - genetics Tumor Microenvironment Xenograft Model Antitumor Assays Xenografts
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