Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

We report on the influence of ~22 million variants on 731 immune cell traits in a cohort of 3,757 Sardinians. We detected 122 significant ( P

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2020-10, Vol.52 (10), p.1036-1045
Hauptverfasser:	Orrù, Valeria, Steri, Maristella, Sidore, Carlo, Marongiu, Michele, Serra, Valentina, Olla, Stefania, Sole, Gabriella, Lai, Sandra, Dei, Mariano, Mulas, Antonella, Virdis, Francesca, Piras, Maria Grazia, Lobina, Monia, Marongiu, Mara, Pitzalis, Maristella, Deidda, Francesca, Loizedda, Annalisa, Onano, Stefano, Zoledziewska, Magdalena, Sawcer, Stephen, Devoto, Marcella, Gorospe, Myriam, Abecasis, Gonçalo R., Floris, Matteo, Pala, Mauro, Schlessinger, David, Fiorillo, Edoardo, Cucca, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 631/250 692/699/249/1313 Adaptive immunity Agriculture Analysis Animal Genetics and Genomics Antigens Autoimmune diseases Autoimmune Diseases - drug therapy Autoimmune Diseases - epidemiology Autoimmune Diseases - genetics Autoimmune Diseases - pathology Autoimmunity Autoimmunity - genetics B cells Biomedical and Life Sciences Biomedicine Cancer Research Disease Drug development Flow cytometry Gene Function Genetic Predisposition to Disease Genome-Wide Association Study Genomes Genomics Health risks Human Genetics Humans Immune system Italy - epidemiology Loci Lymphocytes Pathogenesis Phenotype Phenotypes Polymorphism, Single Nucleotide - genetics Population Therapeutic targets
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We report on the influence of ~22 million variants on 731 immune cell traits in a cohort of 3,757 Sardinians. We detected 122 significant ( P
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-020-0684-4