Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction

Hair follicles (HFs) function as hubs for stem cells, immune cells, and commensal microbes, which must be tightly regulated during homeostasis and transient inflammation. Here we found that transmembrane endopeptidase ADAM10 expression in upper HFs was crucial for regulating the skin microbiota and...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2021-10, Vol.54 (10), p.2321-2337.e10
Hauptverfasser:	Sakamoto, Keiko, Jin, Seon-Pil, Goel, Shubham, Jo, Jay-Hyun, Voisin, Benjamin, Kim, Doyoung, Nadella, Vinod, Liang, Hai, Kobayashi, Tetsuro, Huang, Xin, Deming, Clay, Horiuchi, Keisuke, Segre, Julia A., Kong, Heidi H., Nagao, Keisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM10 alopecia caspase cicatricial alopecia dysbiosis hair follicles innate lymphoid cells Notch pyroptosis skin microbiota
Online-Zugang:	Volltext
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