Chest CT Patterns from Diagnosis to 1 Year of Follow-up in Patients with COVID-19
Background The chest CT manifestations of COVID-19 from hospitalization to convalescence after 1 year are unknown. Purpose To assess chest CT manifestations of COVID-19 up to 1 year after symptom onset. Materials and Methods Patients were enrolled if they were admitted to the hospital because of COV...
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description | Background The chest CT manifestations of COVID-19 from hospitalization to convalescence after 1 year are unknown. Purpose To assess chest CT manifestations of COVID-19 up to 1 year after symptom onset. Materials and Methods Patients were enrolled if they were admitted to the hospital because of COVID-19 and underwent CT during hospitalization at two isolation centers between January 27, 2020, and March 31, 2020. In a prospective study, three serial chest CT scans were obtained at approximately 3, 7, and 12 months after symptom onset and were longitudinally analyzed. The total CT score of pulmonary lobe involvement, ranging from 0 to 25, was assessed (score of 1-5 for each lobe). Univariable and multivariable logistic regression analyses were performed to explore independent risk factors for residual CT abnormalities after 1 year. Results A total of 209 study participants (mean age, 49 years ± 13 [standard deviation]; 116 women) were evaluated. CT abnormalities had resolved in 61% of participants (128 of 209) at 3 months and in 75% of participants (156 of 209) at 12 months. Among participants with chest CT abnormalities that had not resolved, there were residual linear opacities in 25 of the 209 participants (12%) and multifocal reticular or cystic lesions in 28 of the 209 participants (13%). Age 50 years or older, lymphopenia, and severe or aggravation of acute respiratory distress syndrome were independent risk factors for residual CT abnormalities at 1 year (odds ratios = 15.9, 18.9, and 43.9, respectively;
< .001 for each comparison). In 53 participants with residual CT abnormalities at 12 months, reticular lesions (41 of 53 participants [77%]) and bronchial dilation (39 of 53 participants [74%]) were observed at discharge and were persistent in 28 (53%) and 24 (45%) of the 53 participants, respectively. Conclusion One year after COVID-19 diagnosis, chest CT scans showed abnormal findings in 53 of the 209 study participants (25%), with 28 of the 209 participants (13%) showing subpleural reticular or cystic lesions. Older participants with severe COVID-19 or acute respiratory distress syndrome were more likely to develop lung sequelae that persisted at 1 year. © RSNA, 2021
See also the editorial by Lee and Wi et al in this issue. |
doi_str_mv | 10.1148/radiol.2021211199 |
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fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8515211</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2579375710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-b8357d7484acb7cd77bb12fc90e4286330e0c57d3e569ee3f5ef1a81570c6d573</originalsourceid><addsrcrecordid>eNpVUc9PwjAYbYxGEP0DvJgevQz7rStdLyZmiJKQoAmaeGq6roOasWI7JP73joCop-_wfnwv7yF0CaQPkKQ3XhXWVf2YxBADgBBHqAss5hFQYMeoSwilUZqA6KCzEN4JgYSl_BR1aDIgAhjtoudsYUKDsxl-Uk1jfB1w6d0SD62a1y7YgBuHAb8Z5bEr8chVldtE6xW29VZhTd0EvLHNAmfT1_EwAnGOTkpVBXOxvz30MrqfZY_RZPowzu4mkaZCNFGeUsYLnqSJ0jnXBed5DnGpBTFJnA4oJYbolkENGwhjaMlMCSoFxokeFIzTHrrd-a7W-dIUuk3iVSVX3i6V_5JOWfkfqe1Czt2nTFnbEUBrcL038O5j3bYglzZoU1WqNm4dZMy4oJxxIC0VdlTtXQjelIc3QOR2CrmbQv5O0Wqu_uY7KH66p99IcIUT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2579375710</pqid></control><display><type>article</type><title>Chest CT Patterns from Diagnosis to 1 Year of Follow-up in Patients with COVID-19</title><source>MEDLINE</source><source>Radiological Society of North America</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Pan, Feng ; Yang, Lian ; Liang, Bo ; Ye, Tianhe ; Li, Lingli ; Li, Lin ; Liu, Dehan ; Wang, Jiazheng ; Hesketh, Richard L ; Zheng, Chuansheng</creator><creatorcontrib>Pan, Feng ; Yang, Lian ; Liang, Bo ; Ye, Tianhe ; Li, Lingli ; Li, Lin ; Liu, Dehan ; Wang, Jiazheng ; Hesketh, Richard L ; Zheng, Chuansheng</creatorcontrib><description>Background The chest CT manifestations of COVID-19 from hospitalization to convalescence after 1 year are unknown. Purpose To assess chest CT manifestations of COVID-19 up to 1 year after symptom onset. Materials and Methods Patients were enrolled if they were admitted to the hospital because of COVID-19 and underwent CT during hospitalization at two isolation centers between January 27, 2020, and March 31, 2020. In a prospective study, three serial chest CT scans were obtained at approximately 3, 7, and 12 months after symptom onset and were longitudinally analyzed. The total CT score of pulmonary lobe involvement, ranging from 0 to 25, was assessed (score of 1-5 for each lobe). Univariable and multivariable logistic regression analyses were performed to explore independent risk factors for residual CT abnormalities after 1 year. Results A total of 209 study participants (mean age, 49 years ± 13 [standard deviation]; 116 women) were evaluated. CT abnormalities had resolved in 61% of participants (128 of 209) at 3 months and in 75% of participants (156 of 209) at 12 months. Among participants with chest CT abnormalities that had not resolved, there were residual linear opacities in 25 of the 209 participants (12%) and multifocal reticular or cystic lesions in 28 of the 209 participants (13%). Age 50 years or older, lymphopenia, and severe or aggravation of acute respiratory distress syndrome were independent risk factors for residual CT abnormalities at 1 year (odds ratios = 15.9, 18.9, and 43.9, respectively;
< .001 for each comparison). In 53 participants with residual CT abnormalities at 12 months, reticular lesions (41 of 53 participants [77%]) and bronchial dilation (39 of 53 participants [74%]) were observed at discharge and were persistent in 28 (53%) and 24 (45%) of the 53 participants, respectively. Conclusion One year after COVID-19 diagnosis, chest CT scans showed abnormal findings in 53 of the 209 study participants (25%), with 28 of the 209 participants (13%) showing subpleural reticular or cystic lesions. Older participants with severe COVID-19 or acute respiratory distress syndrome were more likely to develop lung sequelae that persisted at 1 year. © RSNA, 2021
See also the editorial by Lee and Wi et al in this issue.</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.2021211199</identifier><identifier>PMID: 34609153</identifier><language>eng</language><publisher>United States: Radiological Society of North America</publisher><subject>COVID-19 - diagnostic imaging ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Original Research ; Pneumonia, Viral - diagnostic imaging ; Pneumonia, Viral - virology ; Prospective Studies ; Radiography, Thoracic ; Risk Factors ; SARS-CoV-2 ; Tomography, X-Ray Computed - methods</subject><ispartof>Radiology, 2022-03, Vol.302 (3), p.709-719</ispartof><rights>2021 by the Radiological Society of North America, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-b8357d7484acb7cd77bb12fc90e4286330e0c57d3e569ee3f5ef1a81570c6d573</citedby><cites>FETCH-LOGICAL-c399t-b8357d7484acb7cd77bb12fc90e4286330e0c57d3e569ee3f5ef1a81570c6d573</cites><orcidid>0000-0001-8101-3580 ; 0000-0002-6217-8029 ; 0000-0002-2435-1417 ; 0000-0003-1182-442X ; 0000-0002-1007-5984 ; 0000-0003-2820-768X ; 0000-0002-9248-4932 ; 0000-0003-4664-2474 ; 0000-0002-0990-911X ; 0000-0002-8109-0815</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4016,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34609153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pan, Feng</creatorcontrib><creatorcontrib>Yang, Lian</creatorcontrib><creatorcontrib>Liang, Bo</creatorcontrib><creatorcontrib>Ye, Tianhe</creatorcontrib><creatorcontrib>Li, Lingli</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Liu, Dehan</creatorcontrib><creatorcontrib>Wang, Jiazheng</creatorcontrib><creatorcontrib>Hesketh, Richard L</creatorcontrib><creatorcontrib>Zheng, Chuansheng</creatorcontrib><title>Chest CT Patterns from Diagnosis to 1 Year of Follow-up in Patients with COVID-19</title><title>Radiology</title><addtitle>Radiology</addtitle><description>Background The chest CT manifestations of COVID-19 from hospitalization to convalescence after 1 year are unknown. Purpose To assess chest CT manifestations of COVID-19 up to 1 year after symptom onset. Materials and Methods Patients were enrolled if they were admitted to the hospital because of COVID-19 and underwent CT during hospitalization at two isolation centers between January 27, 2020, and March 31, 2020. In a prospective study, three serial chest CT scans were obtained at approximately 3, 7, and 12 months after symptom onset and were longitudinally analyzed. The total CT score of pulmonary lobe involvement, ranging from 0 to 25, was assessed (score of 1-5 for each lobe). Univariable and multivariable logistic regression analyses were performed to explore independent risk factors for residual CT abnormalities after 1 year. Results A total of 209 study participants (mean age, 49 years ± 13 [standard deviation]; 116 women) were evaluated. CT abnormalities had resolved in 61% of participants (128 of 209) at 3 months and in 75% of participants (156 of 209) at 12 months. Among participants with chest CT abnormalities that had not resolved, there were residual linear opacities in 25 of the 209 participants (12%) and multifocal reticular or cystic lesions in 28 of the 209 participants (13%). Age 50 years or older, lymphopenia, and severe or aggravation of acute respiratory distress syndrome were independent risk factors for residual CT abnormalities at 1 year (odds ratios = 15.9, 18.9, and 43.9, respectively;
< .001 for each comparison). In 53 participants with residual CT abnormalities at 12 months, reticular lesions (41 of 53 participants [77%]) and bronchial dilation (39 of 53 participants [74%]) were observed at discharge and were persistent in 28 (53%) and 24 (45%) of the 53 participants, respectively. Conclusion One year after COVID-19 diagnosis, chest CT scans showed abnormal findings in 53 of the 209 study participants (25%), with 28 of the 209 participants (13%) showing subpleural reticular or cystic lesions. Older participants with severe COVID-19 or acute respiratory distress syndrome were more likely to develop lung sequelae that persisted at 1 year. © RSNA, 2021
See also the editorial by Lee and Wi et al in this issue.</description><subject>COVID-19 - diagnostic imaging</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Research</subject><subject>Pneumonia, Viral - diagnostic imaging</subject><subject>Pneumonia, Viral - virology</subject><subject>Prospective Studies</subject><subject>Radiography, Thoracic</subject><subject>Risk Factors</subject><subject>SARS-CoV-2</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUc9PwjAYbYxGEP0DvJgevQz7rStdLyZmiJKQoAmaeGq6roOasWI7JP73joCop-_wfnwv7yF0CaQPkKQ3XhXWVf2YxBADgBBHqAss5hFQYMeoSwilUZqA6KCzEN4JgYSl_BR1aDIgAhjtoudsYUKDsxl-Uk1jfB1w6d0SD62a1y7YgBuHAb8Z5bEr8chVldtE6xW29VZhTd0EvLHNAmfT1_EwAnGOTkpVBXOxvz30MrqfZY_RZPowzu4mkaZCNFGeUsYLnqSJ0jnXBed5DnGpBTFJnA4oJYbolkENGwhjaMlMCSoFxokeFIzTHrrd-a7W-dIUuk3iVSVX3i6V_5JOWfkfqe1Czt2nTFnbEUBrcL038O5j3bYglzZoU1WqNm4dZMy4oJxxIC0VdlTtXQjelIc3QOR2CrmbQv5O0Wqu_uY7KH66p99IcIUT</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Pan, Feng</creator><creator>Yang, Lian</creator><creator>Liang, Bo</creator><creator>Ye, Tianhe</creator><creator>Li, Lingli</creator><creator>Li, Lin</creator><creator>Liu, Dehan</creator><creator>Wang, Jiazheng</creator><creator>Hesketh, Richard L</creator><creator>Zheng, Chuansheng</creator><general>Radiological Society of North America</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8101-3580</orcidid><orcidid>https://orcid.org/0000-0002-6217-8029</orcidid><orcidid>https://orcid.org/0000-0002-2435-1417</orcidid><orcidid>https://orcid.org/0000-0003-1182-442X</orcidid><orcidid>https://orcid.org/0000-0002-1007-5984</orcidid><orcidid>https://orcid.org/0000-0003-2820-768X</orcidid><orcidid>https://orcid.org/0000-0002-9248-4932</orcidid><orcidid>https://orcid.org/0000-0003-4664-2474</orcidid><orcidid>https://orcid.org/0000-0002-0990-911X</orcidid><orcidid>https://orcid.org/0000-0002-8109-0815</orcidid></search><sort><creationdate>20220301</creationdate><title>Chest CT Patterns from Diagnosis to 1 Year of Follow-up in Patients with COVID-19</title><author>Pan, Feng ; Yang, Lian ; Liang, Bo ; Ye, Tianhe ; Li, Lingli ; Li, Lin ; Liu, Dehan ; Wang, Jiazheng ; Hesketh, Richard L ; Zheng, Chuansheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-b8357d7484acb7cd77bb12fc90e4286330e0c57d3e569ee3f5ef1a81570c6d573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>COVID-19 - diagnostic imaging</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Research</topic><topic>Pneumonia, Viral - diagnostic imaging</topic><topic>Pneumonia, Viral - virology</topic><topic>Prospective Studies</topic><topic>Radiography, Thoracic</topic><topic>Risk Factors</topic><topic>SARS-CoV-2</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Feng</creatorcontrib><creatorcontrib>Yang, Lian</creatorcontrib><creatorcontrib>Liang, Bo</creatorcontrib><creatorcontrib>Ye, Tianhe</creatorcontrib><creatorcontrib>Li, Lingli</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Liu, Dehan</creatorcontrib><creatorcontrib>Wang, Jiazheng</creatorcontrib><creatorcontrib>Hesketh, Richard L</creatorcontrib><creatorcontrib>Zheng, Chuansheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Feng</au><au>Yang, Lian</au><au>Liang, Bo</au><au>Ye, Tianhe</au><au>Li, Lingli</au><au>Li, Lin</au><au>Liu, Dehan</au><au>Wang, Jiazheng</au><au>Hesketh, Richard L</au><au>Zheng, Chuansheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chest CT Patterns from Diagnosis to 1 Year of Follow-up in Patients with COVID-19</atitle><jtitle>Radiology</jtitle><addtitle>Radiology</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>302</volume><issue>3</issue><spage>709</spage><epage>719</epage><pages>709-719</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><abstract>Background The chest CT manifestations of COVID-19 from hospitalization to convalescence after 1 year are unknown. Purpose To assess chest CT manifestations of COVID-19 up to 1 year after symptom onset. Materials and Methods Patients were enrolled if they were admitted to the hospital because of COVID-19 and underwent CT during hospitalization at two isolation centers between January 27, 2020, and March 31, 2020. In a prospective study, three serial chest CT scans were obtained at approximately 3, 7, and 12 months after symptom onset and were longitudinally analyzed. The total CT score of pulmonary lobe involvement, ranging from 0 to 25, was assessed (score of 1-5 for each lobe). Univariable and multivariable logistic regression analyses were performed to explore independent risk factors for residual CT abnormalities after 1 year. Results A total of 209 study participants (mean age, 49 years ± 13 [standard deviation]; 116 women) were evaluated. CT abnormalities had resolved in 61% of participants (128 of 209) at 3 months and in 75% of participants (156 of 209) at 12 months. Among participants with chest CT abnormalities that had not resolved, there were residual linear opacities in 25 of the 209 participants (12%) and multifocal reticular or cystic lesions in 28 of the 209 participants (13%). Age 50 years or older, lymphopenia, and severe or aggravation of acute respiratory distress syndrome were independent risk factors for residual CT abnormalities at 1 year (odds ratios = 15.9, 18.9, and 43.9, respectively;
< .001 for each comparison). In 53 participants with residual CT abnormalities at 12 months, reticular lesions (41 of 53 participants [77%]) and bronchial dilation (39 of 53 participants [74%]) were observed at discharge and were persistent in 28 (53%) and 24 (45%) of the 53 participants, respectively. Conclusion One year after COVID-19 diagnosis, chest CT scans showed abnormal findings in 53 of the 209 study participants (25%), with 28 of the 209 participants (13%) showing subpleural reticular or cystic lesions. Older participants with severe COVID-19 or acute respiratory distress syndrome were more likely to develop lung sequelae that persisted at 1 year. © RSNA, 2021
See also the editorial by Lee and Wi et al in this issue.</abstract><cop>United States</cop><pub>Radiological Society of North America</pub><pmid>34609153</pmid><doi>10.1148/radiol.2021211199</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8101-3580</orcidid><orcidid>https://orcid.org/0000-0002-6217-8029</orcidid><orcidid>https://orcid.org/0000-0002-2435-1417</orcidid><orcidid>https://orcid.org/0000-0003-1182-442X</orcidid><orcidid>https://orcid.org/0000-0002-1007-5984</orcidid><orcidid>https://orcid.org/0000-0003-2820-768X</orcidid><orcidid>https://orcid.org/0000-0002-9248-4932</orcidid><orcidid>https://orcid.org/0000-0003-4664-2474</orcidid><orcidid>https://orcid.org/0000-0002-0990-911X</orcidid><orcidid>https://orcid.org/0000-0002-8109-0815</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | COVID-19 - diagnostic imaging Disease Progression Female Humans Longitudinal Studies Male Middle Aged Original Research Pneumonia, Viral - diagnostic imaging Pneumonia, Viral - virology Prospective Studies Radiography, Thoracic Risk Factors SARS-CoV-2 Tomography, X-Ray Computed - methods |
title | Chest CT Patterns from Diagnosis to 1 Year of Follow-up in Patients with COVID-19 |
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