Sirolimus and Other Mechanistic Target of Rapamycin Inhibitors Directly Activate Latent Pathogenic Human Polyomavirus Replication

Abstract Background Human polyomaviruses can reactivate in transplant patients, causing nephropathy, progressive multifocal leukoencephalopathy, Merkel cell carcinoma, pruritic, rash or trichodysplasia spinulosa. Sirolimus and related mechanistic target of rapamycin (mTOR) inhibitors are transplant...

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Veröffentlicht in:	The Journal of infectious diseases 2021-10, Vol.224 (7), p.1160-1169
Hauptverfasser:	Alvarez Orellana, Jennifer, Kwun, Hyun Jin, Artusi, Sara, Chang, Yuan, Moore, Patrick S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen T (large) BK Virus Calcineurin Calcineurin inhibitors Deoxyribonucleic acid DNA DNA biosynthesis DNA Replication - drug effects DNA viruses DNA, Viral Humans Immunoblotting Immunofluorescence Immunosuppression Immunosuppressive agents Inhibitor drugs JC Virus Latency Leukoencephalopathy Major and Brief Reports Merkel cell polyomavirus MTOR Inhibitors - pharmacology Nephropathy Pathogenesis Polyomavirus - drug effects Polyomavirus - genetics Polyomavirus Infections - drug therapy Progressive multifocal leukoencephalopathy Rapamycin Replication S-Phase Kinase-Associated Proteins Sirolimus - pharmacology Skin cancer Tacrolimus Tacrolimus - pharmacology TOR protein TOR Serine-Threonine Kinases Ubiquitin-protein ligase Viral infections Virus Replication - drug effects
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