Assessing the Suitability of Next-Generation Viral Outgrowth Assays to Measure Human Immunodeficiency Virus 1 Latent Reservoir Size

Abstract Background Evaluations of human immunodeficiency virus (HIV) curative interventions require reliable and efficient quantification of replication-competent latent reservoirs. The “classic” quantitative viral outgrowth assay (QVOA) has been regarded as the reference standard, although prohibi...

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Veröffentlicht in:	The Journal of infectious diseases 2021-10, Vol.224 (7), p.1209-1218
Hauptverfasser:	Stone, Mars, Rosenbloom, Daniel I S, Bacchetti, Peter, Deng, Xutao, Dimapasoc, Melanie, Keating, Sheila, Bakkour, Sonia, Richman, Douglas D, Mellors, John W, Deeks, Steven G, Lai, Jun, Beg, Subul, Siliciano, Janet D, Pagliuzza, Amélie, Chomont, Nicolas, Lackman-Smith, Carol, Ptak, Roger G, Busch, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Case-Control Studies CD4-Positive T-Lymphocytes High-Throughput Nucleotide Sequencing - methods HIV HIV Infections - drug therapy HIV Infections - virology HIV Reverse Transcriptase HIV-1 - genetics HIV-1 - isolation & purification Human immunodeficiency virus Humans Immune system Laboratories Leukapheresis Major and Brief Reports Markov chains Polymerase chain reaction Variation Viral Load Virus Latency Virus Replication - physiology
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