SARS-CoV-2 infection associated with monoclonal gammopathy. A case report based on the study of minimally invasive ultrasound-guided autopsy
Coronavirus disease-2019 (COVID-19) is a global public health emergency with numerous clinical facets, including acute kidney injury and acute cerebrovascular disease. Further knowledge of its various pathogenic mechanisms is essential, including coagulation disorders. Monoclonal gammopathy is chara...
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| Veröffentlicht in: | Revista española de patología 2022-01, Vol.55 (1), p.41-45 |
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| creator | González-García, María del Carmen Pérez Montero, Pablo Pena Burgos, Eva Manuela Vega Cabrera, Cristina Hernández Cabrero, Teresa Rivas Becerra, Begoña Yébenes, Laura Hardisson, David |
| description | Coronavirus disease-2019 (COVID-19) is a global public health emergency with numerous clinical facets, including acute kidney injury and acute cerebrovascular disease. Further knowledge of its various pathogenic mechanisms is essential, including coagulation disorders. Monoclonal gammopathy is characterized by the overproduction of a monoclonal immunoglobulin caused by clonal proliferation. Using a postmortem study of ultrasound-guided percutaneous core biopsies, the aim of this report is to present our observations on the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection pathology associated with monoclonal gammopathy. The clinical presentation was acute renal failure. Pathological findings revealed kappa light chain cast nephropathy. SARS-CoV-2 immunohistochemistry was positive in some renal tubular cells. Another notable finding was the presence of a high density of alveolar megakaryocytes, which probably explained the final outcome (acute cerebrovascular disease). Immunohistochemical study for SARS-CoV-2 does not verify the pathogenic effect of the virus and thus its contribution to the acute kidney injury.
La enfermedad por coronavirus de 2019 (COVID-19) es una emergencia sanitaria pública global con numerosas facetas clínicas que incluyen enfermedad renal aguda y enfermedad cerebrovascular aguda. Es necesario un conocimiento adicional de su mecanismo patogénico. Los trastornos de coagulación están claramente incluidos en dichos mecanismos. La gammapatía monoclonal se caracteriza por la sobreproducción de inmunoglobulina monoclonal causada por proliferación clonal. Utilizando un estudio postmortem de biopsias percutáneas ecoguiadas, el objetivo de este informe es presentar nuestras observaciones sobre la patología del síndrome respiratorio agudo severo por infección de coronavirus 2 (SARS-CoV-2) con gammapatía monoclonal. La presentación clínica fue insuficiencia renal aguda. Los hallazgos patológicos revelaron nefropatía por cilindros de cadenas ligeras kappa. La inmunohistoquímica de SARS-CoV-2 fue positiva en ciertas células tubulares renales. La presencia de megacariocitos alveolares (alta densidad) fue un hallazgo notable, que explica probablemente el resultado final del paciente (enfermedad cerebrovascular aguda). El estudio inmunohistoquímico frente a SARS-CoV-2 no verifica el efecto patogénico del virus y, por tanto, su contribución a la nefropatía aguda. |
| doi_str_mv | 10.1016/j.patol.2021.07.003 |
| format | Article |
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La enfermedad por coronavirus de 2019 (COVID-19) es una emergencia sanitaria pública global con numerosas facetas clínicas que incluyen enfermedad renal aguda y enfermedad cerebrovascular aguda. Es necesario un conocimiento adicional de su mecanismo patogénico. Los trastornos de coagulación están claramente incluidos en dichos mecanismos. La gammapatía monoclonal se caracteriza por la sobreproducción de inmunoglobulina monoclonal causada por proliferación clonal. Utilizando un estudio postmortem de biopsias percutáneas ecoguiadas, el objetivo de este informe es presentar nuestras observaciones sobre la patología del síndrome respiratorio agudo severo por infección de coronavirus 2 (SARS-CoV-2) con gammapatía monoclonal. La presentación clínica fue insuficiencia renal aguda. Los hallazgos patológicos revelaron nefropatía por cilindros de cadenas ligeras kappa. La inmunohistoquímica de SARS-CoV-2 fue positiva en ciertas células tubulares renales. La presencia de megacariocitos alveolares (alta densidad) fue un hallazgo notable, que explica probablemente el resultado final del paciente (enfermedad cerebrovascular aguda). El estudio inmunohistoquímico frente a SARS-CoV-2 no verifica el efecto patogénico del virus y, por tanto, su contribución a la nefropatía aguda.</description><identifier>ISSN: 1699-8855</identifier><identifier>EISSN: 1988-561X</identifier><identifier>DOI: 10.1016/j.patol.2021.07.003</identifier><identifier>PMID: 34980440</identifier><language>eng</language><publisher>Spain: Elsevier España, S.L.U</publisher><subject>Autopsia mínimamente invasiva ; Autopsy ; Brief Report ; COVID-19 ; Gammapatía monoclonal ; Humans ; Immunothrombosis ; Inmunotrombosis ; Megacariocito ; Megakaryocytes ; Mimimally invasive autopsy ; Monoclonal gammopathy ; Paraproteinemias ; SARS-CoV-2 ; Ultrasonography, Interventional</subject><ispartof>Revista española de patología, 2022-01, Vol.55 (1), p.41-45</ispartof><rights>2021 Sociedad Española de Anatomía Patológica</rights><rights>Copyright © 2021 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.</rights><rights>2021 Sociedad Española de Anatomía Patológica. Published by Elsevier España, S.L.U. All rights reserved. 2021 Sociedad Española de Anatomía Patológica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c376t-e452261842f8f70fcac3ae846cfcad6ba79e2f73762f4b27868f21dcf70f4d8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1699885521000714$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34980440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-García, María del Carmen</creatorcontrib><creatorcontrib>Pérez Montero, Pablo</creatorcontrib><creatorcontrib>Pena Burgos, Eva Manuela</creatorcontrib><creatorcontrib>Vega Cabrera, Cristina</creatorcontrib><creatorcontrib>Hernández Cabrero, Teresa</creatorcontrib><creatorcontrib>Rivas Becerra, Begoña</creatorcontrib><creatorcontrib>Yébenes, Laura</creatorcontrib><creatorcontrib>Hardisson, David</creatorcontrib><title>SARS-CoV-2 infection associated with monoclonal gammopathy. A case report based on the study of minimally invasive ultrasound-guided autopsy</title><title>Revista española de patología</title><addtitle>Rev Esp Patol</addtitle><description>Coronavirus disease-2019 (COVID-19) is a global public health emergency with numerous clinical facets, including acute kidney injury and acute cerebrovascular disease. Further knowledge of its various pathogenic mechanisms is essential, including coagulation disorders. Monoclonal gammopathy is characterized by the overproduction of a monoclonal immunoglobulin caused by clonal proliferation. Using a postmortem study of ultrasound-guided percutaneous core biopsies, the aim of this report is to present our observations on the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection pathology associated with monoclonal gammopathy. The clinical presentation was acute renal failure. Pathological findings revealed kappa light chain cast nephropathy. SARS-CoV-2 immunohistochemistry was positive in some renal tubular cells. Another notable finding was the presence of a high density of alveolar megakaryocytes, which probably explained the final outcome (acute cerebrovascular disease). Immunohistochemical study for SARS-CoV-2 does not verify the pathogenic effect of the virus and thus its contribution to the acute kidney injury.
La enfermedad por coronavirus de 2019 (COVID-19) es una emergencia sanitaria pública global con numerosas facetas clínicas que incluyen enfermedad renal aguda y enfermedad cerebrovascular aguda. Es necesario un conocimiento adicional de su mecanismo patogénico. Los trastornos de coagulación están claramente incluidos en dichos mecanismos. La gammapatía monoclonal se caracteriza por la sobreproducción de inmunoglobulina monoclonal causada por proliferación clonal. Utilizando un estudio postmortem de biopsias percutáneas ecoguiadas, el objetivo de este informe es presentar nuestras observaciones sobre la patología del síndrome respiratorio agudo severo por infección de coronavirus 2 (SARS-CoV-2) con gammapatía monoclonal. La presentación clínica fue insuficiencia renal aguda. Los hallazgos patológicos revelaron nefropatía por cilindros de cadenas ligeras kappa. La inmunohistoquímica de SARS-CoV-2 fue positiva en ciertas células tubulares renales. La presencia de megacariocitos alveolares (alta densidad) fue un hallazgo notable, que explica probablemente el resultado final del paciente (enfermedad cerebrovascular aguda). El estudio inmunohistoquímico frente a SARS-CoV-2 no verifica el efecto patogénico del virus y, por tanto, su contribución a la nefropatía aguda.</description><subject>Autopsia mínimamente invasiva</subject><subject>Autopsy</subject><subject>Brief Report</subject><subject>COVID-19</subject><subject>Gammapatía monoclonal</subject><subject>Humans</subject><subject>Immunothrombosis</subject><subject>Inmunotrombosis</subject><subject>Megacariocito</subject><subject>Megakaryocytes</subject><subject>Mimimally invasive autopsy</subject><subject>Monoclonal gammopathy</subject><subject>Paraproteinemias</subject><subject>SARS-CoV-2</subject><subject>Ultrasonography, Interventional</subject><issn>1699-8855</issn><issn>1988-561X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2q1DAUhYMonuPRJxAkL9CapG2aXigMg39wQPCoeBcyyc5MhjYpSTrSd_ChzTh60BuvsiBrrb03H0LPKakpofzlsZ5VDmPNCKM16WtCmgfomg5CVB2n3x4WzYehEqLrrtCTlI6E8L5rxGN01bSDIG1LrtGPu82nu2obvlYMO29BZxc8VikF7VQGg7-7fMBT8EGPwasR79U0hTL4sNZ4g7VKgCPMIWa8K9rgks4HwCkvZsXB4sl5N6lxXEv9SSV3AryMOaoUFm-q_eJMCaklhzmtT9Ejq8YEz36_N-jL2zeft--r24_vPmw3t5Vuep4raDvGOBUts8L2xGqlGwWi5bpIw3eqH4DZvniZbXesF1xYRo0-e1sjbHODXl9652U3gdHgy0KjnGPZNK4yKCf__fHuIPfhJEVHKRddKWguBTqGlCLY-ywl8gxHHuUvOPIMR5JeFjgl9eLvsfeZPzSK4dXFAOX4k4Mok3bgNRgXCxlpgvvvgJ8A2KbM</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>González-García, María del Carmen</creator><creator>Pérez Montero, Pablo</creator><creator>Pena Burgos, Eva Manuela</creator><creator>Vega Cabrera, Cristina</creator><creator>Hernández Cabrero, Teresa</creator><creator>Rivas Becerra, Begoña</creator><creator>Yébenes, Laura</creator><creator>Hardisson, David</creator><general>Elsevier España, S.L.U</general><general>Sociedad Española de Anatomía Patológica. 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A case report based on the study of minimally invasive ultrasound-guided autopsy</atitle><jtitle>Revista española de patología</jtitle><addtitle>Rev Esp Patol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>55</volume><issue>1</issue><spage>41</spage><epage>45</epage><pages>41-45</pages><issn>1699-8855</issn><eissn>1988-561X</eissn><abstract>Coronavirus disease-2019 (COVID-19) is a global public health emergency with numerous clinical facets, including acute kidney injury and acute cerebrovascular disease. Further knowledge of its various pathogenic mechanisms is essential, including coagulation disorders. Monoclonal gammopathy is characterized by the overproduction of a monoclonal immunoglobulin caused by clonal proliferation. Using a postmortem study of ultrasound-guided percutaneous core biopsies, the aim of this report is to present our observations on the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection pathology associated with monoclonal gammopathy. The clinical presentation was acute renal failure. Pathological findings revealed kappa light chain cast nephropathy. SARS-CoV-2 immunohistochemistry was positive in some renal tubular cells. Another notable finding was the presence of a high density of alveolar megakaryocytes, which probably explained the final outcome (acute cerebrovascular disease). Immunohistochemical study for SARS-CoV-2 does not verify the pathogenic effect of the virus and thus its contribution to the acute kidney injury.
La enfermedad por coronavirus de 2019 (COVID-19) es una emergencia sanitaria pública global con numerosas facetas clínicas que incluyen enfermedad renal aguda y enfermedad cerebrovascular aguda. Es necesario un conocimiento adicional de su mecanismo patogénico. Los trastornos de coagulación están claramente incluidos en dichos mecanismos. La gammapatía monoclonal se caracteriza por la sobreproducción de inmunoglobulina monoclonal causada por proliferación clonal. Utilizando un estudio postmortem de biopsias percutáneas ecoguiadas, el objetivo de este informe es presentar nuestras observaciones sobre la patología del síndrome respiratorio agudo severo por infección de coronavirus 2 (SARS-CoV-2) con gammapatía monoclonal. La presentación clínica fue insuficiencia renal aguda. Los hallazgos patológicos revelaron nefropatía por cilindros de cadenas ligeras kappa. La inmunohistoquímica de SARS-CoV-2 fue positiva en ciertas células tubulares renales. La presencia de megacariocitos alveolares (alta densidad) fue un hallazgo notable, que explica probablemente el resultado final del paciente (enfermedad cerebrovascular aguda). El estudio inmunohistoquímico frente a SARS-CoV-2 no verifica el efecto patogénico del virus y, por tanto, su contribución a la nefropatía aguda.</abstract><cop>Spain</cop><pub>Elsevier España, S.L.U</pub><pmid>34980440</pmid><doi>10.1016/j.patol.2021.07.003</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Revista española de patología, 2022-01, Vol.55 (1), p.41-45 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Autopsia mínimamente invasiva Autopsy Brief Report COVID-19 Gammapatía monoclonal Humans Immunothrombosis Inmunotrombosis Megacariocito Megakaryocytes Mimimally invasive autopsy Monoclonal gammopathy Paraproteinemias SARS-CoV-2 Ultrasonography, Interventional |
| title | SARS-CoV-2 infection associated with monoclonal gammopathy. A case report based on the study of minimally invasive ultrasound-guided autopsy |
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