Severe acute respiratory syndrome coronavirus 2 and seizure: An insight into the pathophysiologic mechanisms

Severe acute respiratory syndrome coronavirus 2 and seizure: An insight into the pathophysiologic mechanisms

Based on previous studies, seizure has been reported to accompany coronavirus disease 2019 (COVID-19). Underlying mechanisms are those leading to the direct central nervous system (CNS) invasion through hematogenous spread or trans-synaptic retrograde invasion, causing meningoencephalitis. On the ot...

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Veröffentlicht in:Current journal of neurology 2021-01, Vol.20 (1), p.43-48
Hauptverfasser: Zareh-Shahamati, Shima, Noorbakhsh, Mahyar, Digaleh, Hadi, Safarpour-Lima, Behnam
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container_title Current journal of neurology
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creator Zareh-Shahamati, Shima
Noorbakhsh, Mahyar
Digaleh, Hadi
Safarpour-Lima, Behnam
description Based on previous studies, seizure has been reported to accompany coronavirus disease 2019 (COVID-19). Underlying mechanisms are those leading to the direct central nervous system (CNS) invasion through hematogenous spread or trans-synaptic retrograde invasion, causing meningoencephalitis. On the other hand, there are pathophysiologic mechanisms that seizure would be one of their early consequences, such as cytokine storm, hypoxemia, metabolic derangement, and structural brain lesions. Herein, we focused on available evidence to provide an insight into the pathophysiologic mechanisms that link seizure and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as a better understanding of pathophysiology would lead to better diagnosis and treatment.
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title Severe acute respiratory syndrome coronavirus 2 and seizure: An insight into the pathophysiologic mechanisms
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