The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-based strategies to combat this disease have been largely unsuccessful to date. We corroborate prior reports that a substantia...

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Veröffentlicht in:	Cancer cell 2021-10, Vol.39 (10), p.1342-1360.e14
Hauptverfasser:	Freed-Pastor, William A., Lambert, Laurens J., Ely, Zackery A., Pattada, Nimisha B., Bhutkar, Arjun, Eng, George, Mercer, Kim L., Garcia, Ana P., Lin, Lin, Rideout, William M., Hwang, William L., Schenkel, Jason M., Jaeger, Alex M., Bronson, Roderick T., Westcott, Peter M.K., Hether, Tyler D., Divakar, Prajan, Reeves, Jason W., Deshpande, Vikram, Delorey, Toni, Phillips, Devan, Yilmaz, Omer H., Regev, Aviv, Jacks, Tyler
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD155 Humans immune evasion Immune Evasion - immunology immunotherapy Immunotherapy - methods Lymphocytes, Tumor-Infiltrating - metabolism Mice pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - immunology Receptors, Virus - immunology TIGIT
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