MicroRNA Expression Profiles and Breast Cancer Chemotherapy
Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the trea...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2021-10, Vol.22 (19), p.10812 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 19 |
| container_start_page | 10812 |
| container_title | International journal of molecular sciences |
| container_volume | 22 |
| creator | Davey, Matthew G Lowery, Aoife J Miller, Nicola Kerin, Michael J |
| description | Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the treatment paradigm to include prescription of chemotherapeutical agents, radiotherapies, targeted therapies, as well as more refined surgical approaches. While treatments with such modalities have enhanced clinico-oncological outcomes for breast cancer patients, the efforts of oncological and translational research have concentrated on the identification of novel biomarkers which may successfully inform prognosis and response to therapies, improve current therapeutic strategies, and enhance prognostication. Mi(cro)RNAs are small, non-coding molecules which are known to play regulatory roles in governing gene expression and cellular activity. Measurement of miRNA expression profiles have been illustrated to inform the response to therapies, such as conventional chemotherapy, and are currently undergoing assessment as means of enhancing treatment strategies with these cytotoxic agents. Herein, this review outlines how chemotherapy prescription has revolutionised breast cancer treatment and illustrates the novel role of miRNAs as biomarkers capable of enhancing current therapeutic strategies using chemotherapy in patients being treated with curative intent for breast cancer. |
| doi_str_mv | 10.3390/ijms221910812 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8509379</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2581014807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-10e4bb9e1eb556cccc6f57649a737e7dfab3d6c9209049c545cf6eb69ff1642b3</originalsourceid><addsrcrecordid>eNpdkctLw0AQxhdRbK0evUrAi5fovpNFEGqpD6gPRM_LZjuxKUm27qZi_3ujraV1LjMwPz7mmw-hY4LPGVP4ophWgVKiCE4J3UFdwimNMZbJ7sbcQQchTDGmjAq1jzqMS6aIoF10-VBY714e-9Hwa-YhhMLV0bN3eVFCiEw9jq49mNBEA1Nb8NFgApVrJuDNbHGI9nJTBjha9R56uxm-Du7i0dPt_aA_ii0XqokJBp5lCghkQkjblsxFIrkyCUsgGecmY2NpFcUKc2UFFzaXkEmV50RymrEeulrqzuZZBWMLdeNNqWe-qIxfaGcKvb2pi4l-d586FVixRLUCZysB7z7mEBpdFcFCWZoa3DxoKlKS0pQT1qKn_9Cpm_u6tfdLYcJTnLRUvKTa34XgIV8fQ7D-iUVvxdLyJ5sO1vRfDuwbGdSI1A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2581014807</pqid></control><display><type>article</type><title>MicroRNA Expression Profiles and Breast Cancer Chemotherapy</title><source>MEDLINE</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Davey, Matthew G ; Lowery, Aoife J ; Miller, Nicola ; Kerin, Michael J</creator><creatorcontrib>Davey, Matthew G ; Lowery, Aoife J ; Miller, Nicola ; Kerin, Michael J</creatorcontrib><description>Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the treatment paradigm to include prescription of chemotherapeutical agents, radiotherapies, targeted therapies, as well as more refined surgical approaches. While treatments with such modalities have enhanced clinico-oncological outcomes for breast cancer patients, the efforts of oncological and translational research have concentrated on the identification of novel biomarkers which may successfully inform prognosis and response to therapies, improve current therapeutic strategies, and enhance prognostication. Mi(cro)RNAs are small, non-coding molecules which are known to play regulatory roles in governing gene expression and cellular activity. Measurement of miRNA expression profiles have been illustrated to inform the response to therapies, such as conventional chemotherapy, and are currently undergoing assessment as means of enhancing treatment strategies with these cytotoxic agents. Herein, this review outlines how chemotherapy prescription has revolutionised breast cancer treatment and illustrates the novel role of miRNAs as biomarkers capable of enhancing current therapeutic strategies using chemotherapy in patients being treated with curative intent for breast cancer.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms221910812</identifier><identifier>PMID: 34639152</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antineoplastic Agents - therapeutic use ; Biomarkers ; Biomarkers, Tumor - genetics ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cancer therapies ; Chemotherapy ; Clinical outcomes ; Clinical trials ; Cytotoxic agents ; Cytotoxicity ; Disease control ; Epidermal growth factor ; Estrogens ; Female ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; Hypotheses ; Malignancy ; Mastectomy ; Medical prognosis ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Oncology ; Patients ; Prognosis ; Radiation therapy ; Review ; Surgery ; Tumors</subject><ispartof>International journal of molecular sciences, 2021-10, Vol.22 (19), p.10812</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-10e4bb9e1eb556cccc6f57649a737e7dfab3d6c9209049c545cf6eb69ff1642b3</citedby><cites>FETCH-LOGICAL-c459t-10e4bb9e1eb556cccc6f57649a737e7dfab3d6c9209049c545cf6eb69ff1642b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509379/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509379/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34639152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davey, Matthew G</creatorcontrib><creatorcontrib>Lowery, Aoife J</creatorcontrib><creatorcontrib>Miller, Nicola</creatorcontrib><creatorcontrib>Kerin, Michael J</creatorcontrib><title>MicroRNA Expression Profiles and Breast Cancer Chemotherapy</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the treatment paradigm to include prescription of chemotherapeutical agents, radiotherapies, targeted therapies, as well as more refined surgical approaches. While treatments with such modalities have enhanced clinico-oncological outcomes for breast cancer patients, the efforts of oncological and translational research have concentrated on the identification of novel biomarkers which may successfully inform prognosis and response to therapies, improve current therapeutic strategies, and enhance prognostication. Mi(cro)RNAs are small, non-coding molecules which are known to play regulatory roles in governing gene expression and cellular activity. Measurement of miRNA expression profiles have been illustrated to inform the response to therapies, such as conventional chemotherapy, and are currently undergoing assessment as means of enhancing treatment strategies with these cytotoxic agents. Herein, this review outlines how chemotherapy prescription has revolutionised breast cancer treatment and illustrates the novel role of miRNAs as biomarkers capable of enhancing current therapeutic strategies using chemotherapy in patients being treated with curative intent for breast cancer.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Cytotoxic agents</subject><subject>Cytotoxicity</subject><subject>Disease control</subject><subject>Epidermal growth factor</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Malignancy</subject><subject>Mastectomy</subject><subject>Medical prognosis</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Review</subject><subject>Surgery</subject><subject>Tumors</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctLw0AQxhdRbK0evUrAi5fovpNFEGqpD6gPRM_LZjuxKUm27qZi_3ujraV1LjMwPz7mmw-hY4LPGVP4ophWgVKiCE4J3UFdwimNMZbJ7sbcQQchTDGmjAq1jzqMS6aIoF10-VBY714e-9Hwa-YhhMLV0bN3eVFCiEw9jq49mNBEA1Nb8NFgApVrJuDNbHGI9nJTBjha9R56uxm-Du7i0dPt_aA_ii0XqokJBp5lCghkQkjblsxFIrkyCUsgGecmY2NpFcUKc2UFFzaXkEmV50RymrEeulrqzuZZBWMLdeNNqWe-qIxfaGcKvb2pi4l-d586FVixRLUCZysB7z7mEBpdFcFCWZoa3DxoKlKS0pQT1qKn_9Cpm_u6tfdLYcJTnLRUvKTa34XgIV8fQ7D-iUVvxdLyJ5sO1vRfDuwbGdSI1A</recordid><startdate>20211006</startdate><enddate>20211006</enddate><creator>Davey, Matthew G</creator><creator>Lowery, Aoife J</creator><creator>Miller, Nicola</creator><creator>Kerin, Michael J</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211006</creationdate><title>MicroRNA Expression Profiles and Breast Cancer Chemotherapy</title><author>Davey, Matthew G ; Lowery, Aoife J ; Miller, Nicola ; Kerin, Michael J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-10e4bb9e1eb556cccc6f57649a737e7dfab3d6c9209049c545cf6eb69ff1642b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Cytotoxic agents</topic><topic>Cytotoxicity</topic><topic>Disease control</topic><topic>Epidermal growth factor</topic><topic>Estrogens</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Malignancy</topic><topic>Mastectomy</topic><topic>Medical prognosis</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Review</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davey, Matthew G</creatorcontrib><creatorcontrib>Lowery, Aoife J</creatorcontrib><creatorcontrib>Miller, Nicola</creatorcontrib><creatorcontrib>Kerin, Michael J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davey, Matthew G</au><au>Lowery, Aoife J</au><au>Miller, Nicola</au><au>Kerin, Michael J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA Expression Profiles and Breast Cancer Chemotherapy</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-10-06</date><risdate>2021</risdate><volume>22</volume><issue>19</issue><spage>10812</spage><pages>10812-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the treatment paradigm to include prescription of chemotherapeutical agents, radiotherapies, targeted therapies, as well as more refined surgical approaches. While treatments with such modalities have enhanced clinico-oncological outcomes for breast cancer patients, the efforts of oncological and translational research have concentrated on the identification of novel biomarkers which may successfully inform prognosis and response to therapies, improve current therapeutic strategies, and enhance prognostication. Mi(cro)RNAs are small, non-coding molecules which are known to play regulatory roles in governing gene expression and cellular activity. Measurement of miRNA expression profiles have been illustrated to inform the response to therapies, such as conventional chemotherapy, and are currently undergoing assessment as means of enhancing treatment strategies with these cytotoxic agents. Herein, this review outlines how chemotherapy prescription has revolutionised breast cancer treatment and illustrates the novel role of miRNAs as biomarkers capable of enhancing current therapeutic strategies using chemotherapy in patients being treated with curative intent for breast cancer.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34639152</pmid><doi>10.3390/ijms221910812</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2021-10, Vol.22 (19), p.10812 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8509379 |
| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antineoplastic Agents - therapeutic use Biomarkers Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer therapies Chemotherapy Clinical outcomes Clinical trials Cytotoxic agents Cytotoxicity Disease control Epidermal growth factor Estrogens Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Humans Hypotheses Malignancy Mastectomy Medical prognosis MicroRNAs MicroRNAs - genetics miRNA Oncology Patients Prognosis Radiation therapy Review Surgery Tumors |
| title | MicroRNA Expression Profiles and Breast Cancer Chemotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T15%3A40%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MicroRNA%20Expression%20Profiles%20and%20Breast%20Cancer%20Chemotherapy&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Davey,%20Matthew%20G&rft.date=2021-10-06&rft.volume=22&rft.issue=19&rft.spage=10812&rft.pages=10812-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms221910812&rft_dat=%3Cproquest_pubme%3E2581014807%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2581014807&rft_id=info:pmid/34639152&rfr_iscdi=true |