LEF1 Enhances the Progression of Colonic Adenocarcinoma via Remodeling the Cell Motility Associated Structures

Lymphoid enhancer-binding factor 1 (LEF1) is a key transcription factor mediating the Wnt signaling pathway. LEF1 is a regulator that is closely associated with tumor malignancy and is usually upregulated in cancers, including colonic adenocarcinoma. The underlying molecular mechanisms of LEF1 regul...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (19), p.10870
Hauptverfasser:	Xiao, Li, Zhang, Caixia, Li, Xinyao, Jia, Chenshuang, Chen, Lirong, Yuan, Yue, Gao, Qian, Lu, Zheng, Feng, Yang, Zhao, Ruixia, Zhao, Xuewei, Cheng, Sinan, Shu, Zhan, Xu, Jie, Duan, Wei, Nie, Guochao, Hou, Yingchun
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adenocarcinoma Apoptosis Cancer Cell division Cell growth Colorectal cancer DNA damage Gene expression Genes Malignancy Mesenchyme Metastasis Microstructure Molecular modelling Morphology Motility Polymerization Proteins RNA polymerase Signal transduction Transcription factors Tubulin Tumors Wnt protein
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