Electroencephalography as a Non-Invasive Biomarker of Alzheimer's Disease: A Forgotten Candidate to Substitute CSF Molecules?
Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow m...
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| Veröffentlicht in: | International journal of molecular sciences 2021-10, Vol.22 (19), p.10889 |
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| container_title | International journal of molecular sciences |
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| creator | Monllor, Paloma Cervera-Ferri, Ana Lloret, Maria-Angeles Esteve, Daniel Lopez, Begoña Leon, Jose-Luis Lloret, Ana |
| description | Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Ideally, biomarkers should also be non-invasive and cost-effective. This review aims to focus on the usefulness and limitations of electroencephalography (EEG) in the search for Alzheimer's disease (AD) biomarkers. The main aim of this article is to review the evolution of the most used biomarkers in AD and the need for new peripheral and, ideally, non-invasive biomarkers. The characteristics of the EEG as a possible source for biomarkers will be revised, highlighting its advantages compared to the molecular markers available so far. |
| doi_str_mv | 10.3390/ijms221910889 |
| format | Article |
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| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alzheimer Disease - diagnosis Alzheimer Disease - diagnostic imaging Alzheimer's disease Animals Biomarkers Biomarkers - analysis Brain research Cerebrospinal fluid Cerebrospinal Fluid - cytology Clinical medicine Dementia EEG Electroencephalography Electroencephalography - methods Humans Mass spectrometry Plasma Proteins Review Scientific imaging Therapeutic applications |
| title | Electroencephalography as a Non-Invasive Biomarker of Alzheimer's Disease: A Forgotten Candidate to Substitute CSF Molecules? |
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