Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan an...

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Veröffentlicht in:	Cell metabolism 2020-09, Vol.32 (3), p.447-456.e6
Hauptverfasser:	Asadi Shahmirzadi, Azar, Edgar, Daniel, Liao, Chen-Yu, Hsu, Yueh-Mei, Lucanic, Mark, Asadi Shahmirzadi, Arash, Wiley, Christopher D., Gan, Garbo, Kim, Dong Eun, Kasler, Herbert G., Kuehnemann, Chisaka, Kaplowitz, Brian, Bhaumik, Dipa, Riley, Rebeccah R., Kennedy, Brian K., Lithgow, Gordon J.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-ketoglutarate frailty healthspan IL-10 inflammation lifespan longevity SASP
Online-Zugang:	Volltext
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