Anti-PD-1/Anti-PD-L1 Drugs and Radiation Therapy: Combinations and Optimization Strategies

Immune checkpoint inhibitors have been associated with long-term complete responses leading to improved overall survival in several cancer types. However, these novel immunotherapies are only effective in a small proportion of patients, and therapeutic resistance represents a major limitation in cli...

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Veröffentlicht in:	Cancers 2021-09, Vol.13 (19), p.4893
Hauptverfasser:	Boustani, Jihane, Lecoester, Benoît, Baude, Jérémy, Latour, Charlène, Adotevi, Olivier, Mirjolet, Céline, Truc, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Cancer therapies Cell death Chemotherapy Clinical trials Colorectal cancer Drug dosages Fractionation Immune checkpoint inhibitors Immune response Immune system Immunogenicity Immunomodulation Immunosuppressive agents Immunotherapy Ligands Lymph nodes Lymphatic system Lymphocytes Optimization Patients PD-1 protein PD-L1 protein Radiation therapy Response rates Review Tumor microenvironment Tumors
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