Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup
We aimed to provide a comprehensive overview of the link between vitamin D and non-melanoma skin cancer (NMSC). For this purpose, we conducted a systematic literature review (updated to 3 February 2021) and meta-analysis of the studies reporting on the association between vitamin D intake (from diet...
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| Veröffentlicht in: | Cancers 2021-09, Vol.13 (19), p.4815 |
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| creator | Caini, Saverio Gnagnarella, Patrizia Stanganelli, Ignazio Bellerba, Federica Cocorocchio, Emilia Queirolo, Paola Bendinelli, Benedetta Saieva, Calogero Raimondi, Sara Gandini, Sara |
| description | We aimed to provide a comprehensive overview of the link between vitamin D and non-melanoma skin cancer (NMSC). For this purpose, we conducted a systematic literature review (updated to 3 February 2021) and meta-analysis of the studies reporting on the association between vitamin D intake (from diet and supplements) and blood concentration, polymorphisms of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes, and the risk of NMSC. Random effects meta-analysis models were fitted to merge study-specific risk estimates into summary relative risk (SRR) and corresponding 95% confidence intervals (CI). Twenty-four studies altogether were included. There was a suggestive association between increasing serum/plasma vitamin D concentration and NMSC risk (SRR for highest vs. lowest concentration 1.67, 95%CI 0.61–4.56), although with large heterogeneity across studies (I2 = 91%). NMSC risk was associated with highest vitamin D intake in observational studies but not in clinical trials. Finally, there was no significant association between any polymorphism of the VDR and VDBP genes and NMSC risk. In conclusion, no strong relationship between vitamin D metabolism and NMSC risk appears to exist according to our systematic review and meta-analysis, although some findings are worthy of further investigation. |
| doi_str_mv | 10.3390/cancers13194815 |
| format | Article |
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For this purpose, we conducted a systematic literature review (updated to 3 February 2021) and meta-analysis of the studies reporting on the association between vitamin D intake (from diet and supplements) and blood concentration, polymorphisms of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes, and the risk of NMSC. Random effects meta-analysis models were fitted to merge study-specific risk estimates into summary relative risk (SRR) and corresponding 95% confidence intervals (CI). Twenty-four studies altogether were included. There was a suggestive association between increasing serum/plasma vitamin D concentration and NMSC risk (SRR for highest vs. lowest concentration 1.67, 95%CI 0.61–4.56), although with large heterogeneity across studies (I2 = 91%). NMSC risk was associated with highest vitamin D intake in observational studies but not in clinical trials. Finally, there was no significant association between any polymorphism of the VDR and VDBP genes and NMSC risk. In conclusion, no strong relationship between vitamin D metabolism and NMSC risk appears to exist according to our systematic review and meta-analysis, although some findings are worthy of further investigation.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13194815</identifier><identifier>PMID: 34638299</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Blood levels ; Clinical trials ; Dietary supplements ; Food ; Food intake ; Gene polymorphism ; Genes ; Literature reviews ; Malignancy ; Melanoma ; Meta-analysis ; Skin cancer ; Systematic Review ; Vitamin D ; Vitamin D receptors ; Vitamin deficiency</subject><ispartof>Cancers, 2021-09, Vol.13 (19), p.4815</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-3a5e54d41d1cddb5b67a1c7e3cb304071e34e53be9aea423ac3ff7e2f7e7ae323</citedby><cites>FETCH-LOGICAL-c398t-3a5e54d41d1cddb5b67a1c7e3cb304071e34e53be9aea423ac3ff7e2f7e7ae323</cites><orcidid>0000-0002-0117-1608 ; 0000-0002-1348-4548 ; 0000-0002-0560-4706 ; 0000-0002-2262-1102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508211/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508211/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Caini, Saverio</creatorcontrib><creatorcontrib>Gnagnarella, Patrizia</creatorcontrib><creatorcontrib>Stanganelli, Ignazio</creatorcontrib><creatorcontrib>Bellerba, Federica</creatorcontrib><creatorcontrib>Cocorocchio, Emilia</creatorcontrib><creatorcontrib>Queirolo, Paola</creatorcontrib><creatorcontrib>Bendinelli, Benedetta</creatorcontrib><creatorcontrib>Saieva, Calogero</creatorcontrib><creatorcontrib>Raimondi, Sara</creatorcontrib><creatorcontrib>Gandini, Sara</creatorcontrib><title>Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup</title><title>Cancers</title><description>We aimed to provide a comprehensive overview of the link between vitamin D and non-melanoma skin cancer (NMSC). 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For this purpose, we conducted a systematic literature review (updated to 3 February 2021) and meta-analysis of the studies reporting on the association between vitamin D intake (from diet and supplements) and blood concentration, polymorphisms of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes, and the risk of NMSC. Random effects meta-analysis models were fitted to merge study-specific risk estimates into summary relative risk (SRR) and corresponding 95% confidence intervals (CI). Twenty-four studies altogether were included. There was a suggestive association between increasing serum/plasma vitamin D concentration and NMSC risk (SRR for highest vs. lowest concentration 1.67, 95%CI 0.61–4.56), although with large heterogeneity across studies (I2 = 91%). NMSC risk was associated with highest vitamin D intake in observational studies but not in clinical trials. Finally, there was no significant association between any polymorphism of the VDR and VDBP genes and NMSC risk. In conclusion, no strong relationship between vitamin D metabolism and NMSC risk appears to exist according to our systematic review and meta-analysis, although some findings are worthy of further investigation.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34638299</pmid><doi>10.3390/cancers13194815</doi><orcidid>https://orcid.org/0000-0002-0117-1608</orcidid><orcidid>https://orcid.org/0000-0002-1348-4548</orcidid><orcidid>https://orcid.org/0000-0002-0560-4706</orcidid><orcidid>https://orcid.org/0000-0002-2262-1102</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood levels Clinical trials Dietary supplements Food Food intake Gene polymorphism Genes Literature reviews Malignancy Melanoma Meta-analysis Skin cancer Systematic Review Vitamin D Vitamin D receptors Vitamin deficiency |
| title | Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup |
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