Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N -Methyltransferase as a Biomarker in Skin Cancers
Skin cancers (SC) collectively represent the most common type of malignancy in white populations. SC includes two main forms: malignant melanoma and non-melanoma skin cancer (NMSC). NMSC includes different subtypes, namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Merkel cell carci...
Gespeichert in:
| Veröffentlicht in: | Cancers 2021-09, Vol.13 (19), p.4943 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 19 |
| container_start_page | 4943 |
| container_title | Cancers |
| container_volume | 13 |
| creator | Campagna, Roberto Pozzi, Valentina Sartini, Davide Salvolini, Eleonora Brisigotti, Valerio Molinelli, Elisa Campanati, Anna Offidani, Annamaria Emanuelli, Monica |
| description | Skin cancers (SC) collectively represent the most common type of malignancy in white populations. SC includes two main forms: malignant melanoma and non-melanoma skin cancer (NMSC). NMSC includes different subtypes, namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Merkel cell carcinoma (MCC), and keratoacanthoma (KA), together with the two pre-neoplastic conditions Bowen disease (BD) and actinic keratosis (AK). Both malignant melanoma and NMSC are showing an increasing incidence rate worldwide, thus representing an important challenge for health care systems, also because, with some exceptions, SC are generally characterized by an aggressive behavior and are often diagnosed late. Thus, identifying new biomarkers suitable for diagnosis, as well as for prognosis and targeted therapy is mandatory. Nicotinamide
-methyltransferase (NNMT) is an enzyme that is emerging as a crucial player in the progression of several malignancies, while its substrate, nicotinamide, is known to exert chemopreventive effects. Since there is increasing evidence regarding the involvement of this enzyme in the malignant behavior of SC, the current review aims to summarize the state of the art as concerns NNMT role in SC and to support future studies focused on exploring the diagnostic and prognostic potential of NNMT in skin malignancies and its suitability for targeted therapy. |
| doi_str_mv | 10.3390/cancers13194943 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8508019</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2581799640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-b327599f91f98bd8458fa8966764a990697b0258c80b22da78d51bf93e3c2e123</originalsourceid><addsrcrecordid>eNpdkctPHSEYxUlTU4267q4h6aabUV7Do4sm9aY-El-x7ZowzDcVnQELc03ufy_mqlFZAAk_DudwEPpMyR7nhux7Fz3kQjk1wgj-AW0xolgjpREfX-030W4pN6QOzqmS6hPa5EJyLZjaQvkAVin2-Dz4NIfoptADPoPZdWkMZfqOL9MMcQ5uxFdpBJyGt-g5bip9vRrn7GIZILsC2BXs8EFIk8u3kHGI-PdtnRZrvztoY3Bjgd2ndRv9Pfz1Z3HcnF4cnSx-njZeaDU3HWeqNWYwdDC667Vo9eC0kVJJ4Ywh0qiOsFZ7TTrGeqd039JuMBy4Z0AZ30Y_1rp3y26C3tcY2Y32Lofqa2WTC_btSQzX9l-6t7olmlBTBb49CeT0fwlltlMoHsbRRUjLYuvjVBkjBano13foTVrmWOM9UsSotv58pfbXlM-plAzDixlK7GOl9l2l9caX1xle-OcC-QNMTZ5T</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580975176</pqid></control><display><type>article</type><title>Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N -Methyltransferase as a Biomarker in Skin Cancers</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Campagna, Roberto ; Pozzi, Valentina ; Sartini, Davide ; Salvolini, Eleonora ; Brisigotti, Valerio ; Molinelli, Elisa ; Campanati, Anna ; Offidani, Annamaria ; Emanuelli, Monica</creator><creatorcontrib>Campagna, Roberto ; Pozzi, Valentina ; Sartini, Davide ; Salvolini, Eleonora ; Brisigotti, Valerio ; Molinelli, Elisa ; Campanati, Anna ; Offidani, Annamaria ; Emanuelli, Monica</creatorcontrib><description>Skin cancers (SC) collectively represent the most common type of malignancy in white populations. SC includes two main forms: malignant melanoma and non-melanoma skin cancer (NMSC). NMSC includes different subtypes, namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Merkel cell carcinoma (MCC), and keratoacanthoma (KA), together with the two pre-neoplastic conditions Bowen disease (BD) and actinic keratosis (AK). Both malignant melanoma and NMSC are showing an increasing incidence rate worldwide, thus representing an important challenge for health care systems, also because, with some exceptions, SC are generally characterized by an aggressive behavior and are often diagnosed late. Thus, identifying new biomarkers suitable for diagnosis, as well as for prognosis and targeted therapy is mandatory. Nicotinamide
-methyltransferase (NNMT) is an enzyme that is emerging as a crucial player in the progression of several malignancies, while its substrate, nicotinamide, is known to exert chemopreventive effects. Since there is increasing evidence regarding the involvement of this enzyme in the malignant behavior of SC, the current review aims to summarize the state of the art as concerns NNMT role in SC and to support future studies focused on exploring the diagnostic and prognostic potential of NNMT in skin malignancies and its suitability for targeted therapy.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13194943</identifier><identifier>PMID: 34638427</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenosine triphosphate ; Basal cell carcinoma ; Biomarkers ; Cancer therapies ; Clinical medicine ; Diagnosis ; Disease ; Health care ; Keratosis ; Malignancy ; Medical prognosis ; Melanoma ; Metabolism ; Metastasis ; Methyltransferase ; N-Methyltransferase ; Nicotinamide N-methyltransferase ; Patients ; Prognosis ; Radiation therapy ; Review ; Skin cancer ; Squamous cell carcinoma ; Tumors</subject><ispartof>Cancers, 2021-09, Vol.13 (19), p.4943</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-b327599f91f98bd8458fa8966764a990697b0258c80b22da78d51bf93e3c2e123</citedby><cites>FETCH-LOGICAL-c487t-b327599f91f98bd8458fa8966764a990697b0258c80b22da78d51bf93e3c2e123</cites><orcidid>0000-0003-2405-8947 ; 0000-0003-2607-2734 ; 0000-0002-3033-8024 ; 0000-0003-3879-8647</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508019/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508019/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34638427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campagna, Roberto</creatorcontrib><creatorcontrib>Pozzi, Valentina</creatorcontrib><creatorcontrib>Sartini, Davide</creatorcontrib><creatorcontrib>Salvolini, Eleonora</creatorcontrib><creatorcontrib>Brisigotti, Valerio</creatorcontrib><creatorcontrib>Molinelli, Elisa</creatorcontrib><creatorcontrib>Campanati, Anna</creatorcontrib><creatorcontrib>Offidani, Annamaria</creatorcontrib><creatorcontrib>Emanuelli, Monica</creatorcontrib><title>Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N -Methyltransferase as a Biomarker in Skin Cancers</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Skin cancers (SC) collectively represent the most common type of malignancy in white populations. SC includes two main forms: malignant melanoma and non-melanoma skin cancer (NMSC). NMSC includes different subtypes, namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Merkel cell carcinoma (MCC), and keratoacanthoma (KA), together with the two pre-neoplastic conditions Bowen disease (BD) and actinic keratosis (AK). Both malignant melanoma and NMSC are showing an increasing incidence rate worldwide, thus representing an important challenge for health care systems, also because, with some exceptions, SC are generally characterized by an aggressive behavior and are often diagnosed late. Thus, identifying new biomarkers suitable for diagnosis, as well as for prognosis and targeted therapy is mandatory. Nicotinamide
-methyltransferase (NNMT) is an enzyme that is emerging as a crucial player in the progression of several malignancies, while its substrate, nicotinamide, is known to exert chemopreventive effects. Since there is increasing evidence regarding the involvement of this enzyme in the malignant behavior of SC, the current review aims to summarize the state of the art as concerns NNMT role in SC and to support future studies focused on exploring the diagnostic and prognostic potential of NNMT in skin malignancies and its suitability for targeted therapy.</description><subject>Adenosine triphosphate</subject><subject>Basal cell carcinoma</subject><subject>Biomarkers</subject><subject>Cancer therapies</subject><subject>Clinical medicine</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Health care</subject><subject>Keratosis</subject><subject>Malignancy</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Metabolism</subject><subject>Metastasis</subject><subject>Methyltransferase</subject><subject>N-Methyltransferase</subject><subject>Nicotinamide N-methyltransferase</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Review</subject><subject>Skin cancer</subject><subject>Squamous cell carcinoma</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctPHSEYxUlTU4267q4h6aabUV7Do4sm9aY-El-x7ZowzDcVnQELc03ufy_mqlFZAAk_DudwEPpMyR7nhux7Fz3kQjk1wgj-AW0xolgjpREfX-030W4pN6QOzqmS6hPa5EJyLZjaQvkAVin2-Dz4NIfoptADPoPZdWkMZfqOL9MMcQ5uxFdpBJyGt-g5bip9vRrn7GIZILsC2BXs8EFIk8u3kHGI-PdtnRZrvztoY3Bjgd2ndRv9Pfz1Z3HcnF4cnSx-njZeaDU3HWeqNWYwdDC667Vo9eC0kVJJ4Ywh0qiOsFZ7TTrGeqd039JuMBy4Z0AZ30Y_1rp3y26C3tcY2Y32Lofqa2WTC_btSQzX9l-6t7olmlBTBb49CeT0fwlltlMoHsbRRUjLYuvjVBkjBano13foTVrmWOM9UsSotv58pfbXlM-plAzDixlK7GOl9l2l9caX1xle-OcC-QNMTZ5T</recordid><startdate>20210930</startdate><enddate>20210930</enddate><creator>Campagna, Roberto</creator><creator>Pozzi, Valentina</creator><creator>Sartini, Davide</creator><creator>Salvolini, Eleonora</creator><creator>Brisigotti, Valerio</creator><creator>Molinelli, Elisa</creator><creator>Campanati, Anna</creator><creator>Offidani, Annamaria</creator><creator>Emanuelli, Monica</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2405-8947</orcidid><orcidid>https://orcid.org/0000-0003-2607-2734</orcidid><orcidid>https://orcid.org/0000-0002-3033-8024</orcidid><orcidid>https://orcid.org/0000-0003-3879-8647</orcidid></search><sort><creationdate>20210930</creationdate><title>Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N -Methyltransferase as a Biomarker in Skin Cancers</title><author>Campagna, Roberto ; Pozzi, Valentina ; Sartini, Davide ; Salvolini, Eleonora ; Brisigotti, Valerio ; Molinelli, Elisa ; Campanati, Anna ; Offidani, Annamaria ; Emanuelli, Monica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-b327599f91f98bd8458fa8966764a990697b0258c80b22da78d51bf93e3c2e123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenosine triphosphate</topic><topic>Basal cell carcinoma</topic><topic>Biomarkers</topic><topic>Cancer therapies</topic><topic>Clinical medicine</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Health care</topic><topic>Keratosis</topic><topic>Malignancy</topic><topic>Medical prognosis</topic><topic>Melanoma</topic><topic>Metabolism</topic><topic>Metastasis</topic><topic>Methyltransferase</topic><topic>N-Methyltransferase</topic><topic>Nicotinamide N-methyltransferase</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Review</topic><topic>Skin cancer</topic><topic>Squamous cell carcinoma</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campagna, Roberto</creatorcontrib><creatorcontrib>Pozzi, Valentina</creatorcontrib><creatorcontrib>Sartini, Davide</creatorcontrib><creatorcontrib>Salvolini, Eleonora</creatorcontrib><creatorcontrib>Brisigotti, Valerio</creatorcontrib><creatorcontrib>Molinelli, Elisa</creatorcontrib><creatorcontrib>Campanati, Anna</creatorcontrib><creatorcontrib>Offidani, Annamaria</creatorcontrib><creatorcontrib>Emanuelli, Monica</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campagna, Roberto</au><au>Pozzi, Valentina</au><au>Sartini, Davide</au><au>Salvolini, Eleonora</au><au>Brisigotti, Valerio</au><au>Molinelli, Elisa</au><au>Campanati, Anna</au><au>Offidani, Annamaria</au><au>Emanuelli, Monica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N -Methyltransferase as a Biomarker in Skin Cancers</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2021-09-30</date><risdate>2021</risdate><volume>13</volume><issue>19</issue><spage>4943</spage><pages>4943-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Skin cancers (SC) collectively represent the most common type of malignancy in white populations. SC includes two main forms: malignant melanoma and non-melanoma skin cancer (NMSC). NMSC includes different subtypes, namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Merkel cell carcinoma (MCC), and keratoacanthoma (KA), together with the two pre-neoplastic conditions Bowen disease (BD) and actinic keratosis (AK). Both malignant melanoma and NMSC are showing an increasing incidence rate worldwide, thus representing an important challenge for health care systems, also because, with some exceptions, SC are generally characterized by an aggressive behavior and are often diagnosed late. Thus, identifying new biomarkers suitable for diagnosis, as well as for prognosis and targeted therapy is mandatory. Nicotinamide
-methyltransferase (NNMT) is an enzyme that is emerging as a crucial player in the progression of several malignancies, while its substrate, nicotinamide, is known to exert chemopreventive effects. Since there is increasing evidence regarding the involvement of this enzyme in the malignant behavior of SC, the current review aims to summarize the state of the art as concerns NNMT role in SC and to support future studies focused on exploring the diagnostic and prognostic potential of NNMT in skin malignancies and its suitability for targeted therapy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34638427</pmid><doi>10.3390/cancers13194943</doi><orcidid>https://orcid.org/0000-0003-2405-8947</orcidid><orcidid>https://orcid.org/0000-0003-2607-2734</orcidid><orcidid>https://orcid.org/0000-0002-3033-8024</orcidid><orcidid>https://orcid.org/0000-0003-3879-8647</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2021-09, Vol.13 (19), p.4943 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8508019 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adenosine triphosphate Basal cell carcinoma Biomarkers Cancer therapies Clinical medicine Diagnosis Disease Health care Keratosis Malignancy Medical prognosis Melanoma Metabolism Metastasis Methyltransferase N-Methyltransferase Nicotinamide N-methyltransferase Patients Prognosis Radiation therapy Review Skin cancer Squamous cell carcinoma Tumors |
| title | Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N -Methyltransferase as a Biomarker in Skin Cancers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T05%3A22%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Beyond%20Nicotinamide%20Metabolism:%20Potential%20Role%20of%20Nicotinamide%20N%20-Methyltransferase%20as%20a%20Biomarker%20in%20Skin%20Cancers&rft.jtitle=Cancers&rft.au=Campagna,%20Roberto&rft.date=2021-09-30&rft.volume=13&rft.issue=19&rft.spage=4943&rft.pages=4943-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers13194943&rft_dat=%3Cproquest_pubme%3E2581799640%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2580975176&rft_id=info:pmid/34638427&rfr_iscdi=true |