Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis

The acclimatization of brown adipose tissue (BAT) to sustained cold exposure requires an adaptive increase in proteasomal protein quality control. Ubiquilins represent a recently identified family of shuttle proteins with versatile functions in protein degradation, such as facilitating substrate tar...

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Veröffentlicht in:	Frontiers in endocrinology (Lausanne) 2021-09, Vol.12, p.739021-739021, Article 739021
Hauptverfasser:	Muley, Carolin, Kotschi, Stefan, Bartelt, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes, Brown - metabolism Adipose Tissue, Brown - metabolism Animals brown adipose tissue Cell Line cold adaptation Endocrinology Endocrinology & Metabolism Endoplasmic Reticulum Stress - physiology Life Sciences & Biomedicine Mice Proteasome Endopeptidase Complex - metabolism proteostasis Proteostasis - physiology Science & Technology thermogenesis Thermogenesis - physiology ubiquilins ubiquitin-proteasome-system Ubiquitins - metabolism Uncoupling Protein 1 - metabolism
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