The association between fat mass and obesity‐associated (FTO) genotype and serum vitamin D level in breast cancer patients
The preventive effect of vitamin D against breast cancer can be influenced by gene polymorphisms. This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients. A cross‐sectional study was carried out on 180 newly diagnosed patient...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2021-10, Vol.25 (20), p.9627-9633 |
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| creator | Gholamalizadeh, Maryam Mokhtari, Zohreh Doaei, Saeid Jalili, Vahideh Davoodi, Sayed Hossein Jonoush, Mona Akbari, Mohammad Esmail Hajipour, Azadeh Bahar, Bojlul Tabesh, Ghasem Azizi Omidi, Saeed Mosavi Jarrahi, Seyed Alireza |
| description | The preventive effect of vitamin D against breast cancer can be influenced by gene polymorphisms. This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients. A cross‐sectional study was carried out on 180 newly diagnosed patients with breast cancer in Tehran, Iran. The blood samples were collected from the participants in order to assess the FTO gene rs9939609 polymorphism by the tetra‐primer amplification refractory mutation system (Tetra‐ARMS) PCR method. The serum level of 25(OH) vitamin D was measured using the direct competitive enzyme‐linked immunosorbent assay (ELISA) method. The association between vitamin D and the FTO genotype in patients with breast cancer was assessed after adjustment for cofounders. The frequency of TT, AT and AA genotypes in the breast cancer patients were 43% (n = 77), 49% (n = 89) and 8% (n = 14), respectively. All patients with higher than 40 ng/dl of serum 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele (p = 0.019). No linear association was found between the number of FTO risk allele and the level of serum vitamin D. All patients with high serum level of 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele. FTO gene polymorphisms may counteract the beneficial effects of vitamin D in breast cancer prevention. Further studies can help to better understand the genetic factors predisposing to breast cancer and their effect on the association between vitamin D and breast cancer. |
| doi_str_mv | 10.1111/jcmm.16908 |
| format | Article |
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This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients. A cross‐sectional study was carried out on 180 newly diagnosed patients with breast cancer in Tehran, Iran. The blood samples were collected from the participants in order to assess the FTO gene rs9939609 polymorphism by the tetra‐primer amplification refractory mutation system (Tetra‐ARMS) PCR method. The serum level of 25(OH) vitamin D was measured using the direct competitive enzyme‐linked immunosorbent assay (ELISA) method. The association between vitamin D and the FTO genotype in patients with breast cancer was assessed after adjustment for cofounders. The frequency of TT, AT and AA genotypes in the breast cancer patients were 43% (n = 77), 49% (n = 89) and 8% (n = 14), respectively. All patients with higher than 40 ng/dl of serum 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele (p = 0.019). No linear association was found between the number of FTO risk allele and the level of serum vitamin D. All patients with high serum level of 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele. FTO gene polymorphisms may counteract the beneficial effects of vitamin D in breast cancer prevention. Further studies can help to better understand the genetic factors predisposing to breast cancer and their effect on the association between vitamin D and breast cancer.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.16908</identifier><identifier>PMID: 34490746</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Abortion ; Adult ; Age ; Aged ; Alcohol ; Alleles ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics ; Biomarkers ; Body fat ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - diagnosis ; Breast Neoplasms - etiology ; Breastfeeding & lactation ; Carbohydrates ; Cell growth ; Consent ; Cross-Sectional Studies ; Deoxyribonucleic acid ; Disease Susceptibility ; DNA ; Enzyme-linked immunosorbent assay ; Family medical history ; Female ; FTO gene ; Gene expression ; Gene polymorphism ; Genetic factors ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Humans ; Kinases ; Menopause ; Middle Aged ; Mutation ; Obesity ; Original ; Physiology ; Polymorphism ; Polymorphism, Single Nucleotide ; Pregnancy ; Proteins ; Questionnaires ; Regression analysis ; Sleep ; Vitamin D ; Vitamin D - blood ; Weight control</subject><ispartof>Journal of cellular and molecular medicine, 2021-10, Vol.25 (20), p.9627-9633</ispartof><rights>2021 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4488-27795f1de4d9c4fa5e873fd7218e529210dd09fd7edcf65089ea7fb8fe0dd783</citedby><cites>FETCH-LOGICAL-c4488-27795f1de4d9c4fa5e873fd7218e529210dd09fd7edcf65089ea7fb8fe0dd783</cites><orcidid>0000-0001-8043-9221 ; 0000-0001-8289-8819</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505832/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505832/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34490746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gholamalizadeh, Maryam</creatorcontrib><creatorcontrib>Mokhtari, Zohreh</creatorcontrib><creatorcontrib>Doaei, Saeid</creatorcontrib><creatorcontrib>Jalili, Vahideh</creatorcontrib><creatorcontrib>Davoodi, Sayed Hossein</creatorcontrib><creatorcontrib>Jonoush, Mona</creatorcontrib><creatorcontrib>Akbari, Mohammad Esmail</creatorcontrib><creatorcontrib>Hajipour, Azadeh</creatorcontrib><creatorcontrib>Bahar, Bojlul</creatorcontrib><creatorcontrib>Tabesh, Ghasem Azizi</creatorcontrib><creatorcontrib>Omidi, Saeed</creatorcontrib><creatorcontrib>Mosavi Jarrahi, Seyed Alireza</creatorcontrib><title>The association between fat mass and obesity‐associated (FTO) genotype and serum vitamin D level in breast cancer patients</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>The preventive effect of vitamin D against breast cancer can be influenced by gene polymorphisms. This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients. A cross‐sectional study was carried out on 180 newly diagnosed patients with breast cancer in Tehran, Iran. The blood samples were collected from the participants in order to assess the FTO gene rs9939609 polymorphism by the tetra‐primer amplification refractory mutation system (Tetra‐ARMS) PCR method. The serum level of 25(OH) vitamin D was measured using the direct competitive enzyme‐linked immunosorbent assay (ELISA) method. The association between vitamin D and the FTO genotype in patients with breast cancer was assessed after adjustment for cofounders. The frequency of TT, AT and AA genotypes in the breast cancer patients were 43% (n = 77), 49% (n = 89) and 8% (n = 14), respectively. All patients with higher than 40 ng/dl of serum 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele (p = 0.019). No linear association was found between the number of FTO risk allele and the level of serum vitamin D. All patients with high serum level of 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele. FTO gene polymorphisms may counteract the beneficial effects of vitamin D in breast cancer prevention. Further studies can help to better understand the genetic factors predisposing to breast cancer and their effect on the association between vitamin D and breast cancer.</description><subject>Abortion</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Alleles</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics</subject><subject>Biomarkers</subject><subject>Body fat</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - etiology</subject><subject>Breastfeeding & lactation</subject><subject>Carbohydrates</subject><subject>Cell growth</subject><subject>Consent</subject><subject>Cross-Sectional Studies</subject><subject>Deoxyribonucleic acid</subject><subject>Disease Susceptibility</subject><subject>DNA</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Family medical history</subject><subject>Female</subject><subject>FTO gene</subject><subject>Gene expression</subject><subject>Gene polymorphism</subject><subject>Genetic factors</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Kinases</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Obesity</subject><subject>Original</subject><subject>Physiology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Sleep</subject><subject>Vitamin D</subject><subject>Vitamin D - 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genetics</topic><topic>Biomarkers</topic><topic>Body fat</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - etiology</topic><topic>Breastfeeding & lactation</topic><topic>Carbohydrates</topic><topic>Cell growth</topic><topic>Consent</topic><topic>Cross-Sectional Studies</topic><topic>Deoxyribonucleic acid</topic><topic>Disease Susceptibility</topic><topic>DNA</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Family medical history</topic><topic>Female</topic><topic>FTO gene</topic><topic>Gene expression</topic><topic>Gene polymorphism</topic><topic>Genetic factors</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Kinases</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Obesity</topic><topic>Original</topic><topic>Physiology</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Sleep</topic><topic>Vitamin D</topic><topic>Vitamin D - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gholamalizadeh, Maryam</au><au>Mokhtari, Zohreh</au><au>Doaei, Saeid</au><au>Jalili, Vahideh</au><au>Davoodi, Sayed Hossein</au><au>Jonoush, Mona</au><au>Akbari, Mohammad Esmail</au><au>Hajipour, Azadeh</au><au>Bahar, Bojlul</au><au>Tabesh, Ghasem Azizi</au><au>Omidi, Saeed</au><au>Mosavi Jarrahi, Seyed Alireza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between fat mass and obesity‐associated (FTO) genotype and serum vitamin D level in breast cancer patients</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2021-10</date><risdate>2021</risdate><volume>25</volume><issue>20</issue><spage>9627</spage><epage>9633</epage><pages>9627-9633</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>The preventive effect of vitamin D against breast cancer can be influenced by gene polymorphisms. This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients. A cross‐sectional study was carried out on 180 newly diagnosed patients with breast cancer in Tehran, Iran. The blood samples were collected from the participants in order to assess the FTO gene rs9939609 polymorphism by the tetra‐primer amplification refractory mutation system (Tetra‐ARMS) PCR method. The serum level of 25(OH) vitamin D was measured using the direct competitive enzyme‐linked immunosorbent assay (ELISA) method. The association between vitamin D and the FTO genotype in patients with breast cancer was assessed after adjustment for cofounders. The frequency of TT, AT and AA genotypes in the breast cancer patients were 43% (n = 77), 49% (n = 89) and 8% (n = 14), respectively. All patients with higher than 40 ng/dl of serum 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele (p = 0.019). No linear association was found between the number of FTO risk allele and the level of serum vitamin D. All patients with high serum level of 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele. FTO gene polymorphisms may counteract the beneficial effects of vitamin D in breast cancer prevention. Further studies can help to better understand the genetic factors predisposing to breast cancer and their effect on the association between vitamin D and breast cancer.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>34490746</pmid><doi>10.1111/jcmm.16908</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8043-9221</orcidid><orcidid>https://orcid.org/0000-0001-8289-8819</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cellular and molecular medicine, 2021-10, Vol.25 (20), p.9627-9633 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central |
| subjects | Abortion Adult Age Aged Alcohol Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Biomarkers Body fat Breast cancer Breast Neoplasms - blood Breast Neoplasms - diagnosis Breast Neoplasms - etiology Breastfeeding & lactation Carbohydrates Cell growth Consent Cross-Sectional Studies Deoxyribonucleic acid Disease Susceptibility DNA Enzyme-linked immunosorbent assay Family medical history Female FTO gene Gene expression Gene polymorphism Genetic factors Genetic Predisposition to Disease Genotype Genotype & phenotype Humans Kinases Menopause Middle Aged Mutation Obesity Original Physiology Polymorphism Polymorphism, Single Nucleotide Pregnancy Proteins Questionnaires Regression analysis Sleep Vitamin D Vitamin D - blood Weight control |
| title | The association between fat mass and obesity‐associated (FTO) genotype and serum vitamin D level in breast cancer patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T16%3A42%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20association%20between%20fat%20mass%20and%20obesity%E2%80%90associated%20(FTO)%20genotype%20and%20serum%20vitamin%20D%20level%20in%20breast%20cancer%20patients&rft.jtitle=Journal%20of%20cellular%20and%20molecular%20medicine&rft.au=Gholamalizadeh,%20Maryam&rft.date=2021-10&rft.volume=25&rft.issue=20&rft.spage=9627&rft.epage=9633&rft.pages=9627-9633&rft.issn=1582-1838&rft.eissn=1582-4934&rft_id=info:doi/10.1111/jcmm.16908&rft_dat=%3Cproquest_pubme%3E2570112403%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2580833720&rft_id=info:pmid/34490746&rfr_iscdi=true |