Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults
Cerebral beta amyloid (Aβ) deposition and late-life depression (LLD) are known to be associated with the trajectory of Alzheimer's disease (AD). However, their neurobiological link is not clear. Previous studies showed aberrant functional connectivity (FC) changes in the default mode network (D...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2021-11, Vol.46 (12), p.2180-2187 |
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| creator | Wang, Sheng-Min Kim, Nak-Young Um, Yoo Hyun Kang, Dong Woo Na, Hae-Ran Lee, Chang Uk Lim, Hyun Kook |
| description | Cerebral beta amyloid (Aβ) deposition and late-life depression (LLD) are known to be associated with the trajectory of Alzheimer's disease (AD). However, their neurobiological link is not clear. Previous studies showed aberrant functional connectivity (FC) changes in the default mode network (DMN) in early Aβ deposition and LLD, but its mediating role has not been elucidated. This study was performed to investigate the distinctive association pattern of DMN FC linking LLD and Aβ retention in cognitively normal older adults. A total of 235 cognitively normal older adults with (n = 118) and without depression (n = 117) underwent resting-state functional magnetic resonance imaging and
F-flutemetamol positron emission tomography to investigate the associations between Aβ burden, depression, and DMN FC. Independent component analysis showed increased anterior DMN FC and decreased posterior DMN FC in the depression group compared with the no depression group. Global cerebral Aβ retention was positively correlated with anterior and negatively correlated with posterior DMN FC. Anterior DMN FC was positively correlated with severity of depression, whereas posterior DMN FC was negatively correlated with cognitive function. In addition, the effects of global cerebral Aβ retention on severity of depression were mediated by subgenual anterior cingulate FC. Our results of anterior and posterior DMN FC dissociation pattern may be pivotal in linking cerebral Aβ pathology and LLD in the course of AD progression. Further longitudinal studies are needed to confirm the causal relationships between cerebral Aβ retention and LLD. |
| doi_str_mv | 10.1038/s41386-021-01072-9 |
| format | Article |
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F-flutemetamol positron emission tomography to investigate the associations between Aβ burden, depression, and DMN FC. Independent component analysis showed increased anterior DMN FC and decreased posterior DMN FC in the depression group compared with the no depression group. Global cerebral Aβ retention was positively correlated with anterior and negatively correlated with posterior DMN FC. Anterior DMN FC was positively correlated with severity of depression, whereas posterior DMN FC was negatively correlated with cognitive function. In addition, the effects of global cerebral Aβ retention on severity of depression were mediated by subgenual anterior cingulate FC. Our results of anterior and posterior DMN FC dissociation pattern may be pivotal in linking cerebral Aβ pathology and LLD in the course of AD progression. Further longitudinal studies are needed to confirm the causal relationships between cerebral Aβ retention and LLD.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/s41386-021-01072-9</identifier><identifier>PMID: 34158614</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Adult ; Alzheimer's disease ; Amyloid beta-Peptides - metabolism ; Brain - diagnostic imaging ; Brain - metabolism ; Brain Mapping ; Cognitive ability ; Default Mode Network ; Depression - diagnostic imaging ; Functional magnetic resonance imaging ; Humans ; Magnetic Resonance Imaging ; Mental depression ; Neural networks ; Neurodegenerative diseases ; Neuropsychological Tests ; Older people ; Positron emission tomography ; Retention ; β-Amyloid</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2021-11, Vol.46 (12), p.2180-2187</ispartof><rights>2021. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.</rights><rights>The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2021.</rights><rights>The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-6d04fe0859e753ffe50729c423b11db4631b686eb5d699da579ffa101b5bf9b53</citedby><cites>FETCH-LOGICAL-c430t-6d04fe0859e753ffe50729c423b11db4631b686eb5d699da579ffa101b5bf9b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505502/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505502/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34158614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Sheng-Min</creatorcontrib><creatorcontrib>Kim, Nak-Young</creatorcontrib><creatorcontrib>Um, Yoo Hyun</creatorcontrib><creatorcontrib>Kang, Dong Woo</creatorcontrib><creatorcontrib>Na, Hae-Ran</creatorcontrib><creatorcontrib>Lee, Chang Uk</creatorcontrib><creatorcontrib>Lim, Hyun Kook</creatorcontrib><title>Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Cerebral beta amyloid (Aβ) deposition and late-life depression (LLD) are known to be associated with the trajectory of Alzheimer's disease (AD). However, their neurobiological link is not clear. Previous studies showed aberrant functional connectivity (FC) changes in the default mode network (DMN) in early Aβ deposition and LLD, but its mediating role has not been elucidated. This study was performed to investigate the distinctive association pattern of DMN FC linking LLD and Aβ retention in cognitively normal older adults. A total of 235 cognitively normal older adults with (n = 118) and without depression (n = 117) underwent resting-state functional magnetic resonance imaging and
F-flutemetamol positron emission tomography to investigate the associations between Aβ burden, depression, and DMN FC. Independent component analysis showed increased anterior DMN FC and decreased posterior DMN FC in the depression group compared with the no depression group. Global cerebral Aβ retention was positively correlated with anterior and negatively correlated with posterior DMN FC. Anterior DMN FC was positively correlated with severity of depression, whereas posterior DMN FC was negatively correlated with cognitive function. In addition, the effects of global cerebral Aβ retention on severity of depression were mediated by subgenual anterior cingulate FC. Our results of anterior and posterior DMN FC dissociation pattern may be pivotal in linking cerebral Aβ pathology and LLD in the course of AD progression. Further longitudinal studies are needed to confirm the causal relationships between cerebral Aβ retention and LLD.</description><subject>Adult</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain Mapping</subject><subject>Cognitive ability</subject><subject>Default Mode Network</subject><subject>Depression - diagnostic imaging</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mental depression</subject><subject>Neural networks</subject><subject>Neurodegenerative diseases</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Positron emission tomography</subject><subject>Retention</subject><subject>β-Amyloid</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkc1rFTEUxYMo9ln9B1xIwI2b0ZvJx8xsBGn9goIbhe5CMrnzTJtJnslM5eE_b15fLSpZhJDfOfceDiHPGbxmwPs3RTDeqwZa1gCDrm2GB2TDOgGN4uLyIdlAP_CGcX55Qp6UcgXAZKf6x-SECyZ7xcSG_DrHyaxhoXNySCMuP1O-ps6XkkZvFp8iDT5e-7ilI2a02QRqcTHUzPuQvKMZF4y3nImOOtxlLOXw9JGOaRv94m8w7GlMea7aFBxmalwdWZ6SR5MJBZ_d3afk24f3X88-NRdfPn4-e3fRjILD0igHYkLo5YCd5NOEsmYdRtFyy5izQnFmVa_QSqeGwRnZDdNkGDAr7TRYyU_J26PvbrUzurHuW2PoXfazyXudjNf__kT_XW_Tje4lSAltNXh1Z5DTjxXLomdfRgzBRExr0a0UQigAfkBf_odepTXHGq9SPdTTwlCp9kiNOZWScbpfhoE-dKuP3erarb7tVh9EL_6OcS_5Uyb_DQFcoxs</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Wang, Sheng-Min</creator><creator>Kim, Nak-Young</creator><creator>Um, Yoo Hyun</creator><creator>Kang, Dong Woo</creator><creator>Na, Hae-Ran</creator><creator>Lee, Chang Uk</creator><creator>Lim, Hyun Kook</creator><general>Nature Publishing Group</general><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211101</creationdate><title>Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults</title><author>Wang, Sheng-Min ; Kim, Nak-Young ; Um, Yoo Hyun ; Kang, Dong Woo ; Na, Hae-Ran ; Lee, Chang Uk ; Lim, Hyun Kook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-6d04fe0859e753ffe50729c423b11db4631b686eb5d699da579ffa101b5bf9b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain Mapping</topic><topic>Cognitive ability</topic><topic>Default Mode Network</topic><topic>Depression - diagnostic imaging</topic><topic>Functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Mental depression</topic><topic>Neural networks</topic><topic>Neurodegenerative diseases</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>Positron emission tomography</topic><topic>Retention</topic><topic>β-Amyloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Sheng-Min</creatorcontrib><creatorcontrib>Kim, Nak-Young</creatorcontrib><creatorcontrib>Um, Yoo Hyun</creatorcontrib><creatorcontrib>Kang, Dong Woo</creatorcontrib><creatorcontrib>Na, Hae-Ran</creatorcontrib><creatorcontrib>Lee, Chang Uk</creatorcontrib><creatorcontrib>Lim, Hyun Kook</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Sheng-Min</au><au>Kim, Nak-Young</au><au>Um, Yoo Hyun</au><au>Kang, Dong Woo</au><au>Na, Hae-Ran</au><au>Lee, Chang Uk</au><au>Lim, Hyun Kook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>46</volume><issue>12</issue><spage>2180</spage><epage>2187</epage><pages>2180-2187</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><abstract>Cerebral beta amyloid (Aβ) deposition and late-life depression (LLD) are known to be associated with the trajectory of Alzheimer's disease (AD). However, their neurobiological link is not clear. Previous studies showed aberrant functional connectivity (FC) changes in the default mode network (DMN) in early Aβ deposition and LLD, but its mediating role has not been elucidated. This study was performed to investigate the distinctive association pattern of DMN FC linking LLD and Aβ retention in cognitively normal older adults. A total of 235 cognitively normal older adults with (n = 118) and without depression (n = 117) underwent resting-state functional magnetic resonance imaging and
F-flutemetamol positron emission tomography to investigate the associations between Aβ burden, depression, and DMN FC. Independent component analysis showed increased anterior DMN FC and decreased posterior DMN FC in the depression group compared with the no depression group. Global cerebral Aβ retention was positively correlated with anterior and negatively correlated with posterior DMN FC. Anterior DMN FC was positively correlated with severity of depression, whereas posterior DMN FC was negatively correlated with cognitive function. In addition, the effects of global cerebral Aβ retention on severity of depression were mediated by subgenual anterior cingulate FC. Our results of anterior and posterior DMN FC dissociation pattern may be pivotal in linking cerebral Aβ pathology and LLD in the course of AD progression. Further longitudinal studies are needed to confirm the causal relationships between cerebral Aβ retention and LLD.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>34158614</pmid><doi>10.1038/s41386-021-01072-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alzheimer's disease Amyloid beta-Peptides - metabolism Brain - diagnostic imaging Brain - metabolism Brain Mapping Cognitive ability Default Mode Network Depression - diagnostic imaging Functional magnetic resonance imaging Humans Magnetic Resonance Imaging Mental depression Neural networks Neurodegenerative diseases Neuropsychological Tests Older people Positron emission tomography Retention β-Amyloid |
| title | Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults |
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