Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth
Bipolar disorder (BD) is highly heritable. Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD participants with a first-degree relative with BD, 25 offspring...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2021-11, Vol.46 (12), p.2207-2216 |
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| creator | Rozovsky, Renata Versace, Amelia Bonar, Lisa K Bertocci, Michele Ladouceur, Cecile D Fournier, Jay Monk, Kelly Abdul-Waalee, Halimah Bebko, Genna Hafeman, Danella Sakolsky, Dara Goldstein, Tina Birmaher, Boris Phillips, Mary L |
| description | Bipolar disorder (BD) is highly heritable. Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD participants with a first-degree relative with BD, 25 offspring of BD parents, 27 offspring of comparison parents with non-BD psychiatric disorders, and 32 healthy offspring of healthy parents. In at-risk groups, 23 had non-BD diagnoses and 29, no Axis-I diagnoses(healthy). Five at-risk offspring who developed BD post scan(Converters) were included. Diffusion imaging(dMRI) analysis with tract segmentation identified between-group differences in the microstructure of prefrontal tracts supporting emotional regulation relevant to BD: forceps minor, anterior thalamic radiation(ATR), cingulum bundle(CB), and uncinate fasciculus(UF). BD participants showed lower fractional anisotropy (FA) in the right CB (anterior portion) than other groups (q |
| doi_str_mv | 10.1038/s41386-021-01088-1 |
| format | Article |
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Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD participants with a first-degree relative with BD, 25 offspring of BD parents, 27 offspring of comparison parents with non-BD psychiatric disorders, and 32 healthy offspring of healthy parents. In at-risk groups, 23 had non-BD diagnoses and 29, no Axis-I diagnoses(healthy). Five at-risk offspring who developed BD post scan(Converters) were included. Diffusion imaging(dMRI) analysis with tract segmentation identified between-group differences in the microstructure of prefrontal tracts supporting emotional regulation relevant to BD: forceps minor, anterior thalamic radiation(ATR), cingulum bundle(CB), and uncinate fasciculus(UF). BD participants showed lower fractional anisotropy (FA) in the right CB (anterior portion) than other groups (q < 0.05); and in bilateral ATR (posterior portion) versus at-risk groups (q < 0.001). Healthy, but not non-BD, at-risk participants showed significantly higher FA in bilateral ATR clusters than healthy controls (qs < 0.05). At-risk groups showed higher FA in these clusters than BD participants (qs < 0.05). Non-BD versus healthy at-risk participants, and Converters versus offspring of BD parents, showed lower FA in the right ATR cluster (qs < 0.05). Low anterior right CB FA in BD participants versus other groups might result from having BD. High bilateral ATR FA in at-risk groups, and in healthy at-risk participants, versus healthy controls might protect against BD/other psychiatric disorders. Absence of elevated right ATR FA in non-BD versus healthy at-risk participants, and in Converters versus non-converter offspring of BD parents, might lower protection against BD in at-risk groups.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/s41386-021-01088-1</identifier><identifier>PMID: 34285367</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Adolescent ; Anisotropy ; At risk youth ; Bipolar Disorder ; Cingulum ; Diffusion Tensor Imaging ; Humans ; Mental disorders ; Offspring ; Psychopathology ; Risk groups ; Segmentation ; Substantia alba ; Thalamus ; White Matter - diagnostic imaging</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2021-11, Vol.46 (12), p.2207-2216</ispartof><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-129c548ca48854b283f3cec97d4adce8da831127519f950f28d04eeedf2e51753</citedby><cites>FETCH-LOGICAL-c430t-129c548ca48854b283f3cec97d4adce8da831127519f950f28d04eeedf2e51753</cites><orcidid>0000-0001-9925-5203 ; 0000-0001-9544-8198 ; 0000-0003-4958-1291 ; 0000-0001-9071-5875 ; 0000-0002-3857-1226 ; 0000-0001-8967-1668 ; 0000-0003-4816-0997</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505429/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505429/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34285367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rozovsky, Renata</creatorcontrib><creatorcontrib>Versace, Amelia</creatorcontrib><creatorcontrib>Bonar, Lisa K</creatorcontrib><creatorcontrib>Bertocci, Michele</creatorcontrib><creatorcontrib>Ladouceur, Cecile D</creatorcontrib><creatorcontrib>Fournier, Jay</creatorcontrib><creatorcontrib>Monk, Kelly</creatorcontrib><creatorcontrib>Abdul-Waalee, Halimah</creatorcontrib><creatorcontrib>Bebko, Genna</creatorcontrib><creatorcontrib>Hafeman, Danella</creatorcontrib><creatorcontrib>Sakolsky, Dara</creatorcontrib><creatorcontrib>Goldstein, Tina</creatorcontrib><creatorcontrib>Birmaher, Boris</creatorcontrib><creatorcontrib>Phillips, Mary L</creatorcontrib><title>Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Bipolar disorder (BD) is highly heritable. Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD participants with a first-degree relative with BD, 25 offspring of BD parents, 27 offspring of comparison parents with non-BD psychiatric disorders, and 32 healthy offspring of healthy parents. In at-risk groups, 23 had non-BD diagnoses and 29, no Axis-I diagnoses(healthy). Five at-risk offspring who developed BD post scan(Converters) were included. Diffusion imaging(dMRI) analysis with tract segmentation identified between-group differences in the microstructure of prefrontal tracts supporting emotional regulation relevant to BD: forceps minor, anterior thalamic radiation(ATR), cingulum bundle(CB), and uncinate fasciculus(UF). BD participants showed lower fractional anisotropy (FA) in the right CB (anterior portion) than other groups (q < 0.05); and in bilateral ATR (posterior portion) versus at-risk groups (q < 0.001). Healthy, but not non-BD, at-risk participants showed significantly higher FA in bilateral ATR clusters than healthy controls (qs < 0.05). At-risk groups showed higher FA in these clusters than BD participants (qs < 0.05). Non-BD versus healthy at-risk participants, and Converters versus offspring of BD parents, showed lower FA in the right ATR cluster (qs < 0.05). Low anterior right CB FA in BD participants versus other groups might result from having BD. High bilateral ATR FA in at-risk groups, and in healthy at-risk participants, versus healthy controls might protect against BD/other psychiatric disorders. Absence of elevated right ATR FA in non-BD versus healthy at-risk participants, and in Converters versus non-converter offspring of BD parents, might lower protection against BD in at-risk groups.</description><subject>Adolescent</subject><subject>Anisotropy</subject><subject>At risk youth</subject><subject>Bipolar Disorder</subject><subject>Cingulum</subject><subject>Diffusion Tensor Imaging</subject><subject>Humans</subject><subject>Mental disorders</subject><subject>Offspring</subject><subject>Psychopathology</subject><subject>Risk groups</subject><subject>Segmentation</subject><subject>Substantia alba</subject><subject>Thalamus</subject><subject>White Matter - diagnostic imaging</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkc1u1DAURi0EotPCC7BAltiwcfHv5GaDhAoFpEpsQOrO8jg3E5ckDrZTNG_AY2OYUgErW9fn--SrQ8gzwc8FV_Aqa6Fgy7gUjAsOwMQDshGN5myr9PVDsuHQKiaUuj4hpznfcC5Ms4XH5ERpCUZtmw358Tb0PSacS3AlzHv6fQgF6eRKwUQndHlNmGkZXKFLigV9oW7vwpwLvc3ndYZdyEvMSEuku7DE0SVaRzF1tcDNHY1lqLclH_wQF1eGOMb9gYaZusJSyF_pIa5leEIe9W7M-PTuPCNfLt99vvjArj69_3jx5op5rXhhQrbeaPBOAxi9k6B65dG3Tadd5xE6B0oI2RjR9q3hvYSOa0TseolGNEadkdfH3mXdTVgjc0lutEsKk0sHG12w_77MYbD7eGvBcKNlWwte3hWk-G3FXOwUssdxdDPGNVtpjALRGuAVffEfehPXNNf1KgUceNWhKyWPlE8x54T9_WcEt79E26NoW0Xb36KtqKHnf69xH_ljVv0E5nKoLw</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Rozovsky, Renata</creator><creator>Versace, Amelia</creator><creator>Bonar, Lisa K</creator><creator>Bertocci, Michele</creator><creator>Ladouceur, Cecile D</creator><creator>Fournier, Jay</creator><creator>Monk, Kelly</creator><creator>Abdul-Waalee, Halimah</creator><creator>Bebko, Genna</creator><creator>Hafeman, Danella</creator><creator>Sakolsky, Dara</creator><creator>Goldstein, Tina</creator><creator>Birmaher, Boris</creator><creator>Phillips, Mary L</creator><general>Nature Publishing Group</general><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9925-5203</orcidid><orcidid>https://orcid.org/0000-0001-9544-8198</orcidid><orcidid>https://orcid.org/0000-0003-4958-1291</orcidid><orcidid>https://orcid.org/0000-0001-9071-5875</orcidid><orcidid>https://orcid.org/0000-0002-3857-1226</orcidid><orcidid>https://orcid.org/0000-0001-8967-1668</orcidid><orcidid>https://orcid.org/0000-0003-4816-0997</orcidid></search><sort><creationdate>20211101</creationdate><title>Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth</title><author>Rozovsky, Renata ; Versace, Amelia ; Bonar, Lisa K ; Bertocci, Michele ; Ladouceur, Cecile D ; Fournier, Jay ; Monk, Kelly ; Abdul-Waalee, Halimah ; Bebko, Genna ; Hafeman, Danella ; Sakolsky, Dara ; Goldstein, Tina ; Birmaher, Boris ; Phillips, Mary L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-129c548ca48854b283f3cec97d4adce8da831127519f950f28d04eeedf2e51753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Anisotropy</topic><topic>At risk youth</topic><topic>Bipolar Disorder</topic><topic>Cingulum</topic><topic>Diffusion Tensor Imaging</topic><topic>Humans</topic><topic>Mental disorders</topic><topic>Offspring</topic><topic>Psychopathology</topic><topic>Risk groups</topic><topic>Segmentation</topic><topic>Substantia alba</topic><topic>Thalamus</topic><topic>White Matter - 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Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD participants with a first-degree relative with BD, 25 offspring of BD parents, 27 offspring of comparison parents with non-BD psychiatric disorders, and 32 healthy offspring of healthy parents. In at-risk groups, 23 had non-BD diagnoses and 29, no Axis-I diagnoses(healthy). Five at-risk offspring who developed BD post scan(Converters) were included. Diffusion imaging(dMRI) analysis with tract segmentation identified between-group differences in the microstructure of prefrontal tracts supporting emotional regulation relevant to BD: forceps minor, anterior thalamic radiation(ATR), cingulum bundle(CB), and uncinate fasciculus(UF). BD participants showed lower fractional anisotropy (FA) in the right CB (anterior portion) than other groups (q < 0.05); and in bilateral ATR (posterior portion) versus at-risk groups (q < 0.001). Healthy, but not non-BD, at-risk participants showed significantly higher FA in bilateral ATR clusters than healthy controls (qs < 0.05). At-risk groups showed higher FA in these clusters than BD participants (qs < 0.05). Non-BD versus healthy at-risk participants, and Converters versus offspring of BD parents, showed lower FA in the right ATR cluster (qs < 0.05). Low anterior right CB FA in BD participants versus other groups might result from having BD. High bilateral ATR FA in at-risk groups, and in healthy at-risk participants, versus healthy controls might protect against BD/other psychiatric disorders. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Anisotropy At risk youth Bipolar Disorder Cingulum Diffusion Tensor Imaging Humans Mental disorders Offspring Psychopathology Risk groups Segmentation Substantia alba Thalamus White Matter - diagnostic imaging |
| title | Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth |
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