Data-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein

The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2021-12, Vol.413 (29), p.7305-7318
Hauptverfasser:	Chang, Deborah, Klein, Joshua A., Nalehua, Mary Rachel, Hackett, William E., Zaia, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Analysis Analytical Characterization of Viruses Analytical Chemistry Antigenicity Biochemistry Bioinformatics Cell fusion Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Confidence intervals COVID-19 COVID-19 - virology Data acquisition Food Science Gene sequencing Genomes Glycomics - methods Glycopeptides Glycoproteins Glycosylation Humans Identification and classification Laboratory Medicine Limit of Detection Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Methods Monitoring/Environmental Analysis Mutation Pandemics Proteins Proteomics Proteomics - methods Reproducibility of Results Research Paper SARS-CoV-2 - metabolism Scientific imaging Selectivity Severe acute respiratory syndrome coronavirus 2 Spectroscopy Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - metabolism Spike protein Tracking Vaccine development Vaccines Viral diseases Viruses
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