Effects of Acanthopanax senticosus supplementation on innate immunity and changes of related immune factors in healthy mice
Modern scientific research has shown that Acanthopanax senticosus (AS) can regulate the innate immunity of healthy animals, thus affecting the health of animals. However, there are few systematic reports on the changes of innate immune indices of healthy animals after consuming AS. The purpose of th...
Gespeichert in:
| Veröffentlicht in: | Innate immunity (London, England) England), 2021-08, Vol.27 (6), p.461-469 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 469 |
|---|---|
| container_issue | 6 |
| container_start_page | 461 |
| container_title | Innate immunity (London, England) |
| container_volume | 27 |
| creator | Zhang, YunQiang Zhang, YunLu Liu, ZiKui |
| description | Modern scientific research has shown that Acanthopanax senticosus (AS) can regulate the innate immunity of healthy animals, thus affecting the health of animals. However, there are few systematic reports on the changes of innate immune indices of healthy animals after consuming AS. The purpose of this project was to study the effect on healthy mice’s innate immunity and changes of related immune factors induced by feeding AS root powder supplementation. The results showed that the killing rate of natural cells increased in a dose-dependent manner in a certain time period. Compared to the control group, the treatment groups (T1, T2 and T3) improved significantly in the innate immune index (lysozyme, β-defensin-2 and duodenal secretory IgA (SIgA) to varying degrees) and induced corresponding changes of immune factors at certain time periods. The correlation between SIgA and IFN-γ in mouse serum was enhanced, and the higher the concentration of AS in the diet, the stronger the correlation was. However, there was no significant difference in growth performance among groups. It is proved that AS supplementation can enhance innate immunity and change several relevant immune factors and cells of healthy mice without affecting growth performance. |
| doi_str_mv | 10.1177/1753425920955200 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8504262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1753425920955200</sage_id><sourcerecordid>2443881738</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-1a6401598e6af754ebdf48e351e62df0578fd638cf2f4c84bf6af13a2d850153</originalsourceid><addsrcrecordid>eNp1kc1rFTEUxYMo9kP3riTgxs3YfM5kNkIptQqFbroPeZmbNykzyZhkxIf_vGlffWqhEEi493dOcnIRekfJJ0q77ox2kgsme0Z6KRkhL9DxfakRrO1eHs6yP0InOd8R0jIiu9foiLOeK6baY_Tr0jmwJePo8Lk1oYxxMcH8xBlC8TbmNeO8LssEcy2Y4mPAdfkQTAHs53kNvuywCQO2owlbeHBKMNX2sO8DdsaWmHJV4RHMVMYdnr2FN-iVM1OGt4_7Kbr9cnl78bW5vrn6dnF-3VjRstJQ0wpCZa-gNa6TAjaDEwq4pNCywdVEyg0tV9YxJ6wSG1c5yg0blKw6foo-722XdTPDYGuOZCa9JD-btNPReP1_J_hRb-MPXeX1I1k1-PhokOL3FXLRs88WpskEiGvWTAiuFO24quiHJ-hdXFOo6TSTXS9FzxivFNlTNsWcE7jDYyjR94PVTwdbJe__DXEQ_JlkBZo9kM0W_t76rOFvjMOtsg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2579549223</pqid></control><display><type>article</type><title>Effects of Acanthopanax senticosus supplementation on innate immunity and changes of related immune factors in healthy mice</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Sage Journals GOLD Open Access 2024</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhang, YunQiang ; Zhang, YunLu ; Liu, ZiKui</creator><creatorcontrib>Zhang, YunQiang ; Zhang, YunLu ; Liu, ZiKui</creatorcontrib><description>Modern scientific research has shown that Acanthopanax senticosus (AS) can regulate the innate immunity of healthy animals, thus affecting the health of animals. However, there are few systematic reports on the changes of innate immune indices of healthy animals after consuming AS. The purpose of this project was to study the effect on healthy mice’s innate immunity and changes of related immune factors induced by feeding AS root powder supplementation. The results showed that the killing rate of natural cells increased in a dose-dependent manner in a certain time period. Compared to the control group, the treatment groups (T1, T2 and T3) improved significantly in the innate immune index (lysozyme, β-defensin-2 and duodenal secretory IgA (SIgA) to varying degrees) and induced corresponding changes of immune factors at certain time periods. The correlation between SIgA and IFN-γ in mouse serum was enhanced, and the higher the concentration of AS in the diet, the stronger the correlation was. However, there was no significant difference in growth performance among groups. It is proved that AS supplementation can enhance innate immunity and change several relevant immune factors and cells of healthy mice without affecting growth performance.</description><identifier>ISSN: 1753-4259</identifier><identifier>EISSN: 1753-4267</identifier><identifier>DOI: 10.1177/1753425920955200</identifier><identifier>PMID: 32938286</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acanthopanax ; Animals ; Animals, Outbred Strains ; beta-Defensins - metabolism ; Dietary Supplements ; Duodenum - metabolism ; Eleutherococcus - immunology ; Female ; Humans ; Immunity, Innate - immunology ; Immunoglobulin A ; Immunoglobulin A - metabolism ; Innate immunity ; Interferon-gamma - metabolism ; Lysozyme ; Medicine, Chinese Traditional - methods ; Mice ; Muramidase - metabolism ; Original ; Plant Roots - immunology ; γ-Interferon</subject><ispartof>Innate immunity (London, England), 2021-08, Vol.27 (6), p.461-469</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020 2020 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-1a6401598e6af754ebdf48e351e62df0578fd638cf2f4c84bf6af13a2d850153</citedby><cites>FETCH-LOGICAL-c462t-1a6401598e6af754ebdf48e351e62df0578fd638cf2f4c84bf6af13a2d850153</cites><orcidid>0000-0003-3172-9120</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504262/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504262/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,21966,27853,27924,27925,44945,45333,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32938286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, YunQiang</creatorcontrib><creatorcontrib>Zhang, YunLu</creatorcontrib><creatorcontrib>Liu, ZiKui</creatorcontrib><title>Effects of Acanthopanax senticosus supplementation on innate immunity and changes of related immune factors in healthy mice</title><title>Innate immunity (London, England)</title><addtitle>Innate Immun</addtitle><description>Modern scientific research has shown that Acanthopanax senticosus (AS) can regulate the innate immunity of healthy animals, thus affecting the health of animals. However, there are few systematic reports on the changes of innate immune indices of healthy animals after consuming AS. The purpose of this project was to study the effect on healthy mice’s innate immunity and changes of related immune factors induced by feeding AS root powder supplementation. The results showed that the killing rate of natural cells increased in a dose-dependent manner in a certain time period. Compared to the control group, the treatment groups (T1, T2 and T3) improved significantly in the innate immune index (lysozyme, β-defensin-2 and duodenal secretory IgA (SIgA) to varying degrees) and induced corresponding changes of immune factors at certain time periods. The correlation between SIgA and IFN-γ in mouse serum was enhanced, and the higher the concentration of AS in the diet, the stronger the correlation was. However, there was no significant difference in growth performance among groups. It is proved that AS supplementation can enhance innate immunity and change several relevant immune factors and cells of healthy mice without affecting growth performance.</description><subject>Acanthopanax</subject><subject>Animals</subject><subject>Animals, Outbred Strains</subject><subject>beta-Defensins - metabolism</subject><subject>Dietary Supplements</subject><subject>Duodenum - metabolism</subject><subject>Eleutherococcus - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Innate - immunology</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin A - metabolism</subject><subject>Innate immunity</subject><subject>Interferon-gamma - metabolism</subject><subject>Lysozyme</subject><subject>Medicine, Chinese Traditional - methods</subject><subject>Mice</subject><subject>Muramidase - metabolism</subject><subject>Original</subject><subject>Plant Roots - immunology</subject><subject>γ-Interferon</subject><issn>1753-4259</issn><issn>1753-4267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kc1rFTEUxYMo9kP3riTgxs3YfM5kNkIptQqFbroPeZmbNykzyZhkxIf_vGlffWqhEEi493dOcnIRekfJJ0q77ox2kgsme0Z6KRkhL9DxfakRrO1eHs6yP0InOd8R0jIiu9foiLOeK6baY_Tr0jmwJePo8Lk1oYxxMcH8xBlC8TbmNeO8LssEcy2Y4mPAdfkQTAHs53kNvuywCQO2owlbeHBKMNX2sO8DdsaWmHJV4RHMVMYdnr2FN-iVM1OGt4_7Kbr9cnl78bW5vrn6dnF-3VjRstJQ0wpCZa-gNa6TAjaDEwq4pNCywdVEyg0tV9YxJ6wSG1c5yg0blKw6foo-722XdTPDYGuOZCa9JD-btNPReP1_J_hRb-MPXeX1I1k1-PhokOL3FXLRs88WpskEiGvWTAiuFO24quiHJ-hdXFOo6TSTXS9FzxivFNlTNsWcE7jDYyjR94PVTwdbJe__DXEQ_JlkBZo9kM0W_t76rOFvjMOtsg</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Zhang, YunQiang</creator><creator>Zhang, YunLu</creator><creator>Liu, ZiKui</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8C1</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3172-9120</orcidid></search><sort><creationdate>20210801</creationdate><title>Effects of Acanthopanax senticosus supplementation on innate immunity and changes of related immune factors in healthy mice</title><author>Zhang, YunQiang ; Zhang, YunLu ; Liu, ZiKui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-1a6401598e6af754ebdf48e351e62df0578fd638cf2f4c84bf6af13a2d850153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acanthopanax</topic><topic>Animals</topic><topic>Animals, Outbred Strains</topic><topic>beta-Defensins - metabolism</topic><topic>Dietary Supplements</topic><topic>Duodenum - metabolism</topic><topic>Eleutherococcus - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity, Innate - immunology</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin A - metabolism</topic><topic>Innate immunity</topic><topic>Interferon-gamma - metabolism</topic><topic>Lysozyme</topic><topic>Medicine, Chinese Traditional - methods</topic><topic>Mice</topic><topic>Muramidase - metabolism</topic><topic>Original</topic><topic>Plant Roots - immunology</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, YunQiang</creatorcontrib><creatorcontrib>Zhang, YunLu</creatorcontrib><creatorcontrib>Liu, ZiKui</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Public Health Database</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Innate immunity (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, YunQiang</au><au>Zhang, YunLu</au><au>Liu, ZiKui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Acanthopanax senticosus supplementation on innate immunity and changes of related immune factors in healthy mice</atitle><jtitle>Innate immunity (London, England)</jtitle><addtitle>Innate Immun</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>27</volume><issue>6</issue><spage>461</spage><epage>469</epage><pages>461-469</pages><issn>1753-4259</issn><eissn>1753-4267</eissn><abstract>Modern scientific research has shown that Acanthopanax senticosus (AS) can regulate the innate immunity of healthy animals, thus affecting the health of animals. However, there are few systematic reports on the changes of innate immune indices of healthy animals after consuming AS. The purpose of this project was to study the effect on healthy mice’s innate immunity and changes of related immune factors induced by feeding AS root powder supplementation. The results showed that the killing rate of natural cells increased in a dose-dependent manner in a certain time period. Compared to the control group, the treatment groups (T1, T2 and T3) improved significantly in the innate immune index (lysozyme, β-defensin-2 and duodenal secretory IgA (SIgA) to varying degrees) and induced corresponding changes of immune factors at certain time periods. The correlation between SIgA and IFN-γ in mouse serum was enhanced, and the higher the concentration of AS in the diet, the stronger the correlation was. However, there was no significant difference in growth performance among groups. It is proved that AS supplementation can enhance innate immunity and change several relevant immune factors and cells of healthy mice without affecting growth performance.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32938286</pmid><doi>10.1177/1753425920955200</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3172-9120</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1753-4259 |
| ispartof | Innate immunity (London, England), 2021-08, Vol.27 (6), p.461-469 |
| issn | 1753-4259 1753-4267 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8504262 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; PubMed Central; Alma/SFX Local Collection |
| subjects | Acanthopanax Animals Animals, Outbred Strains beta-Defensins - metabolism Dietary Supplements Duodenum - metabolism Eleutherococcus - immunology Female Humans Immunity, Innate - immunology Immunoglobulin A Immunoglobulin A - metabolism Innate immunity Interferon-gamma - metabolism Lysozyme Medicine, Chinese Traditional - methods Mice Muramidase - metabolism Original Plant Roots - immunology γ-Interferon |
| title | Effects of Acanthopanax senticosus supplementation on innate immunity and changes of related immune factors in healthy mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T11%3A22%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Acanthopanax%20senticosus%20supplementation%20on%20innate%20immunity%20and%20changes%20of%20related%20immune%20factors%20in%20healthy%20mice&rft.jtitle=Innate%20immunity%20(London,%20England)&rft.au=Zhang,%20YunQiang&rft.date=2021-08-01&rft.volume=27&rft.issue=6&rft.spage=461&rft.epage=469&rft.pages=461-469&rft.issn=1753-4259&rft.eissn=1753-4267&rft_id=info:doi/10.1177/1753425920955200&rft_dat=%3Cproquest_pubme%3E2443881738%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2579549223&rft_id=info:pmid/32938286&rft_sage_id=10.1177_1753425920955200&rfr_iscdi=true |