mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Here we report on the antibody and memory B cell responses of a cohort of 20 volunteers who received the Moderna (mRNA-1273) or Pfizer–BioNTech (BNT162b2) vaccine against SARS-CoV-2 1 – 4 . Eight weeks after the second injection of vaccine, volunteers showed high levels of IgM and IgG anti-SARS-CoV-...

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Veröffentlicht in:	Nature (London) 2021-04, Vol.592 (7855), p.616-622
Hauptverfasser:	Wang, Zijun, Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Barnes, Christopher O., Finkin, Shlomo, Schaefer-Babajew, Dennis, Cipolla, Melissa, Gaebler, Christian, Lieberman, Jenna A., Oliveira, Thiago Y., Yang, Zhi, Abernathy, Morgan E., Huey-Tubman, Kathryn E., Hurley, Arlene, Turroja, Martina, West, Kamille A., Gordon, Kristie, Millard, Katrina G., Ramos, Victor, Da Silva, Justin, Xu, Jianliang, Colbert, Robert A., Patel, Roshni, Dizon, Juan, Unson-O’Brien, Cecille, Shimeliovich, Irina, Gazumyan, Anna, Caskey, Marina, Bjorkman, Pamela J., Casellas, Rafael, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 2019-nCoV Vaccine mRNA-1273 631/250/2152/2153/1291 631/250/2499 631/326/596/4130 Adult Aged Analysis Antibodies, Monoclonal - blood Antibodies, Monoclonal - immunology Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology B-Lymphocytes - immunology Binding Blood & organ donations BNT162 Vaccine Cloning Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - virology COVID-19 vaccines COVID-19 Vaccines - genetics COVID-19 Vaccines - immunology Cryoelectron Microscopy Epitopes Epitopes, B-Lymphocyte - chemistry Epitopes, B-Lymphocyte - immunology Epitopes, B-Lymphocyte - ultrastructure Female Flow cytometry HIV Human immunodeficiency virus Humanities and Social Sciences Humans Immunization Immunization, Secondary Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - blood Immunoglobulin M - immunology Immunologic Memory - immunology Immunological memory Infections Lymphocytes B Male Memory cells Middle Aged Models, Molecular Monoclonal antibodies mRNA mRNA Vaccines multidisciplinary Mutation Neutralization Neutralization Tests Plasma SARS-CoV-2 - genetics SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike protein Stomatitis Testing Vaccines Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Viruses
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