Suppression of liquid-liquid phase separation by 1,6-hexanediol partially compromises the 3D genome organization in living cells

Liquid-liquid phase separation (LLPS) contributes to the spatial and functional segregation of molecular processes within the cell nucleus. However, the role played by LLPS in chromatin folding in living cells remains unclear. Here, using stochastic optical reconstruction microscopy (STORM) and Hi-C...

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Veröffentlicht in:	Nucleic acids research 2021-10, Vol.49 (18), p.10524-10541
Hauptverfasser:	Ulianov, Sergey V, Velichko, Artem K, Magnitov, Mikhail D, Luzhin, Artem V, Golov, Arkadiy K, Ovsyannikova, Natalia, Kireev, Igor I, Gavrikov, Alexey S, Mishin, Alexander S, Garaev, Azat K, Tyakht, Alexander V, Gavrilov, Alexey A, Kantidze, Omar L, Razin, Sergey V
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatin - chemistry Chromatin - drug effects Enhancer Elements, Genetic - drug effects Genome, Human Genomics Glycols - pharmacology HeLa Cells Humans Microscopy Promoter Regions, Genetic - drug effects
Online-Zugang:	Volltext
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