Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration

Regeneration of the architecturally complex alveolar niche of the lung requires precise temporal and spatial control of epithelial cell behavior. Injury can lead to a permanent reduction in gas exchange surface area and respiratory function. Using mouse models, we show that alveolar type 1 (AT1) cel...

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Veröffentlicht in:	Cell stem cell 2021-10, Vol.28 (10), p.1775-1789.e5
Hauptverfasser:	Penkala, Ian J., Liberti, Derek C., Pankin, Joshua, Sivakumar, Aravind, Kremp, Madison M., Jayachandran, Sowmya, Katzen, Jeremy, Leach, John P., Windmueller, Rebecca, Stolz, Katharine, Morley, Michael P., Babu, Apoorva, Zhou, Su, Frank, David B., Morrisey, Edward E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Epithelial Cells alveolus Animals cellular plasticity Hippo Homeostasis Lung Mice regeneration Respiratory Mucosa Signal Transduction
Online-Zugang:	Volltext
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