circ_0023461 Silencing Protects Cardiomyocytes from Hypoxia-Induced Dysfunction through Targeting miR-370-3p/PDE4D Signaling

Background. Acute myocardial infarction (AMI) is a common cardiovascular disease with high disability and mortality. Circular RNAs (circRNAs) are implicated in the pathomechanism of multiple human diseases, including AMI. This study intended to explore the function and working mechanism of a novel c...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.8379962-8379962
Hauptverfasser:	Ren, Kai, Li, Buying, Jiang, Liqing, Liu, Zhiheng, Wu, Fan, Zhang, Yi, Liu, Jincheng, Duan, Weixun
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Bioinformatics Cardiomyocytes Cardiovascular disease Case-Control Studies Cell Hypoxia - genetics Cell Line Cell Movement - genetics Cell Proliferation - genetics Cell Survival - genetics Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Dehydrogenases Enzymes Gene expression Gene Silencing Glycolysis - genetics Heart attacks Humans Hypoxia Ischemia MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Myocardial Infarction - blood Myocytes, Cardiac - metabolism Oxidative Stress - genetics Plasmids Reagents Reverse Transcriptase Polymerase Chain Reaction RNA, Circular - blood RNA, Circular - genetics Signal Transduction - genetics Transfection Tumor necrosis factor-TNF Up-Regulation - genetics Variance analysis
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