Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning
Abstract Background Frailty (physical frailty phenotype [PFP]) and its criteria (slow gait, weakness, weight loss, low activity, and exhaustion) are each associated with cognitive dysfunction. The extent to which the PFP is associated with cognition beyond that expected from its component parts rema...
Gespeichert in:
| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2021-09, Vol.76 (9), p.1633-1642 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1642 |
|---|---|
| container_issue | 9 |
| container_start_page | 1633 |
| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
| container_volume | 76 |
| creator | Chu, Nadia M Bandeen-Roche, Karen Xue, Qian-Li Carlson, Michelle C Sharrett, A Richey Gross, Alden L |
| description | Abstract
Background
Frailty (physical frailty phenotype [PFP]) and its criteria (slow gait, weakness, weight loss, low activity, and exhaustion) are each associated with cognitive dysfunction. The extent to which the PFP is associated with cognition beyond that expected from its component parts remains uncertain.
Method
We used the National Health and Aging Trends Study to quantify associations between PFP criteria and cognitive performance (level/change) using adjusted mixed effects models. We tested whether frailty was associated with excess cognitive vulnerability (synergistic/excess effects, Cohen’s d) beyond criteria contributions by assessing interactions between each criterion and frailty.
Results
Among 7439 community-dwelling older adults (mean age = 75.2 years) followed for a mean of 3.2 years (SE = 0.03), 14.1% were frail. The PFP and PFP criteria were all associated with lower baseline cognitive performance, among which slow gait (−0.31 SD, SE = 0.02) and frailty (−0.23 SD, SE = 0.02) were strongest. Only slow gait (−0.03 SD/year, SE = 0.01), frailty (−0.02 SD/year, SE = 0.01), weight loss (−0.02 SD/year, SE = 0.01), and weakness (−0.02 SD/year, SE = 0.01) were associated with cognitive decline. Frailty was associated with cognitive performance above and beyond each criterion (excess effects ranging from −0.07 SD [SE = −0.05] for slow gait to −0.23 SD [SE = 0.03] for weakness); the same was not true for cognitive decline. Slow gait was the only criterion associated with cognitive change among both frail and nonfrail participants (frail: Cohen’s d/year = −0.03, SE = 0.01; nonfrail: Cohen’s d/year = −0.02, SE = 0.01).
Conclusions
PFP is an important frailty measure that is cross-sectionally associated with lower cognitive performance, but not with subsequent cognitive decline, above and beyond its criteria contributions. Further research into the construct of frailty as a “syndrome” correlated with cognition and other adverse outcomes is needed. |
| doi_str_mv | 10.1093/gerona/glaa267 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8499264</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/gerona/glaa267</oup_id><sourcerecordid>2570234645</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-ef77463680afdf96510f83e1a864a54fb3bdda88fd8f9a8df07031996030afe13</originalsourceid><addsrcrecordid>eNqFkc9rFDEUxwex2Fq9epSAl3qYNpn8mOQilMWtQsGCFTwZ3s4ksymzyZpkCvPfm2W3xfbSR-CF5PP98h7fqvpA8DnBil4MJgYPF8MI0Ij2VXVCWi5rTvnv1-WOW1VzjMVx9TalO7wr3rypjinFvBVYnVR_btZzch2MaBnBjXlGN2vjQ563Bi2iyyY6QOB7dLs2LqKfszdxcCm7Dl2mFDoH2QWPylmEwbvs7g1aTr7bvTo_vKuOLIzJvD_00-rX8uvt4lt9_ePq--Lyuu4Yb3JtbNsyQYXEYHurBCfYSmoISMGAM7uiq74HKW0vrQLZW9xiSpQSmBaFIfS0-rL33U6rjek743OEUW-j20CcdQCnn_54t9ZDuNeSKdUIVgzODgYx_J1MynrjUmfGEbwJU9IN40SWEfkO_fQMvQtT9GU93fAWN5QJxgt1vqe6GFKKxj4OQ7DeRaf30elDdEXw8f8VHvGHrArweQ-EafuS2T_SRqd7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2570234645</pqid></control><display><type>article</type><title>Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning</title><source>MEDLINE</source><source>Sociological Abstracts</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Chu, Nadia M ; Bandeen-Roche, Karen ; Xue, Qian-Li ; Carlson, Michelle C ; Sharrett, A Richey ; Gross, Alden L</creator><contributor>Newman, Anne</contributor><creatorcontrib>Chu, Nadia M ; Bandeen-Roche, Karen ; Xue, Qian-Li ; Carlson, Michelle C ; Sharrett, A Richey ; Gross, Alden L ; Newman, Anne</creatorcontrib><description>Abstract
Background
Frailty (physical frailty phenotype [PFP]) and its criteria (slow gait, weakness, weight loss, low activity, and exhaustion) are each associated with cognitive dysfunction. The extent to which the PFP is associated with cognition beyond that expected from its component parts remains uncertain.
Method
We used the National Health and Aging Trends Study to quantify associations between PFP criteria and cognitive performance (level/change) using adjusted mixed effects models. We tested whether frailty was associated with excess cognitive vulnerability (synergistic/excess effects, Cohen’s d) beyond criteria contributions by assessing interactions between each criterion and frailty.
Results
Among 7439 community-dwelling older adults (mean age = 75.2 years) followed for a mean of 3.2 years (SE = 0.03), 14.1% were frail. The PFP and PFP criteria were all associated with lower baseline cognitive performance, among which slow gait (−0.31 SD, SE = 0.02) and frailty (−0.23 SD, SE = 0.02) were strongest. Only slow gait (−0.03 SD/year, SE = 0.01), frailty (−0.02 SD/year, SE = 0.01), weight loss (−0.02 SD/year, SE = 0.01), and weakness (−0.02 SD/year, SE = 0.01) were associated with cognitive decline. Frailty was associated with cognitive performance above and beyond each criterion (excess effects ranging from −0.07 SD [SE = −0.05] for slow gait to −0.23 SD [SE = 0.03] for weakness); the same was not true for cognitive decline. Slow gait was the only criterion associated with cognitive change among both frail and nonfrail participants (frail: Cohen’s d/year = −0.03, SE = 0.01; nonfrail: Cohen’s d/year = −0.02, SE = 0.01).
Conclusions
PFP is an important frailty measure that is cross-sectionally associated with lower cognitive performance, but not with subsequent cognitive decline, above and beyond its criteria contributions. Further research into the construct of frailty as a “syndrome” correlated with cognition and other adverse outcomes is needed.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glaa267</identifier><identifier>PMID: 33057609</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Body weight loss ; Cognition & reasoning ; Cognitive ability ; Cognitive Dysfunction - physiopathology ; Cognitive functioning ; Female ; Frail Elderly - psychology ; Frailty ; Frailty - physiopathology ; Gait ; Geriatric Assessment ; Gerontology ; Humans ; Male ; Older people ; Phenotype ; Phenotypes ; Prospective Studies ; THE JOURNAL OF GERONTOLOGY: Medical Sciences ; United States</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2021-09, Vol.76 (9), p.1633-1642</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press Sep 2021</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-ef77463680afdf96510f83e1a864a54fb3bdda88fd8f9a8df07031996030afe13</citedby><cites>FETCH-LOGICAL-c452t-ef77463680afdf96510f83e1a864a54fb3bdda88fd8f9a8df07031996030afe13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1583,27915,27916,33765</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33057609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Newman, Anne</contributor><creatorcontrib>Chu, Nadia M</creatorcontrib><creatorcontrib>Bandeen-Roche, Karen</creatorcontrib><creatorcontrib>Xue, Qian-Li</creatorcontrib><creatorcontrib>Carlson, Michelle C</creatorcontrib><creatorcontrib>Sharrett, A Richey</creatorcontrib><creatorcontrib>Gross, Alden L</creatorcontrib><title>Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Abstract
Background
Frailty (physical frailty phenotype [PFP]) and its criteria (slow gait, weakness, weight loss, low activity, and exhaustion) are each associated with cognitive dysfunction. The extent to which the PFP is associated with cognition beyond that expected from its component parts remains uncertain.
Method
We used the National Health and Aging Trends Study to quantify associations between PFP criteria and cognitive performance (level/change) using adjusted mixed effects models. We tested whether frailty was associated with excess cognitive vulnerability (synergistic/excess effects, Cohen’s d) beyond criteria contributions by assessing interactions between each criterion and frailty.
Results
Among 7439 community-dwelling older adults (mean age = 75.2 years) followed for a mean of 3.2 years (SE = 0.03), 14.1% were frail. The PFP and PFP criteria were all associated with lower baseline cognitive performance, among which slow gait (−0.31 SD, SE = 0.02) and frailty (−0.23 SD, SE = 0.02) were strongest. Only slow gait (−0.03 SD/year, SE = 0.01), frailty (−0.02 SD/year, SE = 0.01), weight loss (−0.02 SD/year, SE = 0.01), and weakness (−0.02 SD/year, SE = 0.01) were associated with cognitive decline. Frailty was associated with cognitive performance above and beyond each criterion (excess effects ranging from −0.07 SD [SE = −0.05] for slow gait to −0.23 SD [SE = 0.03] for weakness); the same was not true for cognitive decline. Slow gait was the only criterion associated with cognitive change among both frail and nonfrail participants (frail: Cohen’s d/year = −0.03, SE = 0.01; nonfrail: Cohen’s d/year = −0.02, SE = 0.01).
Conclusions
PFP is an important frailty measure that is cross-sectionally associated with lower cognitive performance, but not with subsequent cognitive decline, above and beyond its criteria contributions. Further research into the construct of frailty as a “syndrome” correlated with cognition and other adverse outcomes is needed.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Body weight loss</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive functioning</subject><subject>Female</subject><subject>Frail Elderly - psychology</subject><subject>Frailty</subject><subject>Frailty - physiopathology</subject><subject>Gait</subject><subject>Geriatric Assessment</subject><subject>Gerontology</subject><subject>Humans</subject><subject>Male</subject><subject>Older people</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Prospective Studies</subject><subject>THE JOURNAL OF GERONTOLOGY: Medical Sciences</subject><subject>United States</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BHHNA</sourceid><recordid>eNqFkc9rFDEUxwex2Fq9epSAl3qYNpn8mOQilMWtQsGCFTwZ3s4ksymzyZpkCvPfm2W3xfbSR-CF5PP98h7fqvpA8DnBil4MJgYPF8MI0Ij2VXVCWi5rTvnv1-WOW1VzjMVx9TalO7wr3rypjinFvBVYnVR_btZzch2MaBnBjXlGN2vjQ563Bi2iyyY6QOB7dLs2LqKfszdxcCm7Dl2mFDoH2QWPylmEwbvs7g1aTr7bvTo_vKuOLIzJvD_00-rX8uvt4lt9_ePq--Lyuu4Yb3JtbNsyQYXEYHurBCfYSmoISMGAM7uiq74HKW0vrQLZW9xiSpQSmBaFIfS0-rL33U6rjek743OEUW-j20CcdQCnn_54t9ZDuNeSKdUIVgzODgYx_J1MynrjUmfGEbwJU9IN40SWEfkO_fQMvQtT9GU93fAWN5QJxgt1vqe6GFKKxj4OQ7DeRaf30elDdEXw8f8VHvGHrArweQ-EafuS2T_SRqd7</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Chu, Nadia M</creator><creator>Bandeen-Roche, Karen</creator><creator>Xue, Qian-Li</creator><creator>Carlson, Michelle C</creator><creator>Sharrett, A Richey</creator><creator>Gross, Alden L</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U3</scope><scope>BHHNA</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210901</creationdate><title>Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning</title><author>Chu, Nadia M ; Bandeen-Roche, Karen ; Xue, Qian-Li ; Carlson, Michelle C ; Sharrett, A Richey ; Gross, Alden L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-ef77463680afdf96510f83e1a864a54fb3bdda88fd8f9a8df07031996030afe13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Body weight loss</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cognitive functioning</topic><topic>Female</topic><topic>Frail Elderly - psychology</topic><topic>Frailty</topic><topic>Frailty - physiopathology</topic><topic>Gait</topic><topic>Geriatric Assessment</topic><topic>Gerontology</topic><topic>Humans</topic><topic>Male</topic><topic>Older people</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Prospective Studies</topic><topic>THE JOURNAL OF GERONTOLOGY: Medical Sciences</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chu, Nadia M</creatorcontrib><creatorcontrib>Bandeen-Roche, Karen</creatorcontrib><creatorcontrib>Xue, Qian-Li</creatorcontrib><creatorcontrib>Carlson, Michelle C</creatorcontrib><creatorcontrib>Sharrett, A Richey</creatorcontrib><creatorcontrib>Gross, Alden L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chu, Nadia M</au><au>Bandeen-Roche, Karen</au><au>Xue, Qian-Li</au><au>Carlson, Michelle C</au><au>Sharrett, A Richey</au><au>Gross, Alden L</au><au>Newman, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>76</volume><issue>9</issue><spage>1633</spage><epage>1642</epage><pages>1633-1642</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Abstract
Background
Frailty (physical frailty phenotype [PFP]) and its criteria (slow gait, weakness, weight loss, low activity, and exhaustion) are each associated with cognitive dysfunction. The extent to which the PFP is associated with cognition beyond that expected from its component parts remains uncertain.
Method
We used the National Health and Aging Trends Study to quantify associations between PFP criteria and cognitive performance (level/change) using adjusted mixed effects models. We tested whether frailty was associated with excess cognitive vulnerability (synergistic/excess effects, Cohen’s d) beyond criteria contributions by assessing interactions between each criterion and frailty.
Results
Among 7439 community-dwelling older adults (mean age = 75.2 years) followed for a mean of 3.2 years (SE = 0.03), 14.1% were frail. The PFP and PFP criteria were all associated with lower baseline cognitive performance, among which slow gait (−0.31 SD, SE = 0.02) and frailty (−0.23 SD, SE = 0.02) were strongest. Only slow gait (−0.03 SD/year, SE = 0.01), frailty (−0.02 SD/year, SE = 0.01), weight loss (−0.02 SD/year, SE = 0.01), and weakness (−0.02 SD/year, SE = 0.01) were associated with cognitive decline. Frailty was associated with cognitive performance above and beyond each criterion (excess effects ranging from −0.07 SD [SE = −0.05] for slow gait to −0.23 SD [SE = 0.03] for weakness); the same was not true for cognitive decline. Slow gait was the only criterion associated with cognitive change among both frail and nonfrail participants (frail: Cohen’s d/year = −0.03, SE = 0.01; nonfrail: Cohen’s d/year = −0.02, SE = 0.01).
Conclusions
PFP is an important frailty measure that is cross-sectionally associated with lower cognitive performance, but not with subsequent cognitive decline, above and beyond its criteria contributions. Further research into the construct of frailty as a “syndrome” correlated with cognition and other adverse outcomes is needed.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33057609</pmid><doi>10.1093/gerona/glaa267</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-5006 |
| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2021-09, Vol.76 (9), p.1633-1642 |
| issn | 1079-5006 1758-535X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8499264 |
| source | MEDLINE; Sociological Abstracts; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Aging Body weight loss Cognition & reasoning Cognitive ability Cognitive Dysfunction - physiopathology Cognitive functioning Female Frail Elderly - psychology Frailty Frailty - physiopathology Gait Geriatric Assessment Gerontology Humans Male Older people Phenotype Phenotypes Prospective Studies THE JOURNAL OF GERONTOLOGY: Medical Sciences United States |
| title | Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T01%3A53%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Physical%20Frailty%20Phenotype%20Criteria%20and%20Their%20Synergistic%20Association%20on%20Cognitive%20Functioning&rft.jtitle=The%20journals%20of%20gerontology.%20Series%20A,%20Biological%20sciences%20and%20medical%20sciences&rft.au=Chu,%20Nadia%20M&rft.date=2021-09-01&rft.volume=76&rft.issue=9&rft.spage=1633&rft.epage=1642&rft.pages=1633-1642&rft.issn=1079-5006&rft.eissn=1758-535X&rft_id=info:doi/10.1093/gerona/glaa267&rft_dat=%3Cproquest_pubme%3E2570234645%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2570234645&rft_id=info:pmid/33057609&rft_oup_id=10.1093/gerona/glaa267&rfr_iscdi=true |