Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats
Protaetia brevitarsis seulensis is an animal‐based medicine used traditionally in China, Japan, and Korea to treat hepatic disorders; it has been shown to possess various pharmacological effects such as antibacterial and antioxidant activities. In this study, we investigated the effects of P. brevit...
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| description | Protaetia brevitarsis seulensis is an animal‐based medicine used traditionally in China, Japan, and Korea to treat hepatic disorders; it has been shown to possess various pharmacological effects such as antibacterial and antioxidant activities. In this study, we investigated the effects of P. brevitarsis on a testosterone‐induced benign prostatic hyperplasia (BPH) rat model. To establish the BPH model, the animals were administered a subcutaneous injection of testosterone daily for 28 days. P. brevitarsis was administered by oral gavage at doses of 12.5, 25, and 50 mg/kg for 28 days, along with testosterone injection. P. brevitarsis treatment markedly decreased the absolute and relative prostate weight of BPH animals. The levels of dihydrotestosterone was reduced in P. brevitarsis‐treated animals compared to those in the BPH animals. Histological analysis of the prostate showed that P. brevitarsis treatment effectively suppressed the testosterone‐induced hyperplasia of prostatic epithelial cells, which was accompanied by reductions in the PCNA and Ki‐67 expressions in prostatic tissues. These results indicate that P. brevitarsis effectively suppresses testosterone‐induced development of BPH, and thus, is a potential therapeutic agent for BPH.
Treatment with Protaetia brevitarsis seulensis extracts (PBE) reduced prostate weight, dihydrotestosterone levels of benign prostatic hyperplasia (BPH) animals. Furthermore, PBE attenuated the testosterone‐induced hyperplasia and proliferation of prostatic epithelial cells. These results indicate that P. brevitarsis is a potential therapeutic agent for BPH. |
| doi_str_mv | 10.1002/fsn3.2460 |
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Treatment with Protaetia brevitarsis seulensis extracts (PBE) reduced prostate weight, dihydrotestosterone levels of benign prostatic hyperplasia (BPH) animals. Furthermore, PBE attenuated the testosterone‐induced hyperplasia and proliferation of prostatic epithelial cells. These results indicate that P. brevitarsis is a potential therapeutic agent for BPH.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.2460</identifier><identifier>PMID: 34646508</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adrenergic receptors ; Androgens ; Animals ; Antioxidants ; benign prostatic hyperplasia ; Chemical compounds ; Dihydrotestosterone ; Epithelial cells ; Epithelium ; Genital diseases ; Hyperplasia ; Injection ; Laboratories ; Medicine ; Original Research ; Pharmacology ; Prostate ; Protaetia brevitarsis ; Protaetia brevitarsis seulensison ; Proteins ; Testosterone</subject><ispartof>Food science & nutrition, 2021-10, Vol.9 (10), p.5361-5369</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC</rights><rights>2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4430-7f55dbf67fe3b6007a0dcd558fc0e70bcae74781022e8682fabdf90505e90cb93</citedby><cites>FETCH-LOGICAL-c4430-7f55dbf67fe3b6007a0dcd558fc0e70bcae74781022e8682fabdf90505e90cb93</cites><orcidid>0000-0003-2180-4860 ; 0000-0003-4414-3495</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498080/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498080/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34646508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seo, Yun‐Soo</creatorcontrib><creatorcontrib>Shin, Na‐Rea</creatorcontrib><creatorcontrib>Nam, Hyeon Hwa</creatorcontrib><creatorcontrib>Song, Jun‐Ho</creatorcontrib><creatorcontrib>Cheol Moon, Byeong</creatorcontrib><creatorcontrib>Choi, Goya</creatorcontrib><creatorcontrib>Shin, In‐Sik</creatorcontrib><creatorcontrib>Kim, Joong‐Sun</creatorcontrib><title>Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats</title><title>Food science & nutrition</title><addtitle>Food Sci Nutr</addtitle><description>Protaetia brevitarsis seulensis is an animal‐based medicine used traditionally in China, Japan, and Korea to treat hepatic disorders; it has been shown to possess various pharmacological effects such as antibacterial and antioxidant activities. In this study, we investigated the effects of P. brevitarsis on a testosterone‐induced benign prostatic hyperplasia (BPH) rat model. To establish the BPH model, the animals were administered a subcutaneous injection of testosterone daily for 28 days. P. brevitarsis was administered by oral gavage at doses of 12.5, 25, and 50 mg/kg for 28 days, along with testosterone injection. P. brevitarsis treatment markedly decreased the absolute and relative prostate weight of BPH animals. The levels of dihydrotestosterone was reduced in P. brevitarsis‐treated animals compared to those in the BPH animals. Histological analysis of the prostate showed that P. brevitarsis treatment effectively suppressed the testosterone‐induced hyperplasia of prostatic epithelial cells, which was accompanied by reductions in the PCNA and Ki‐67 expressions in prostatic tissues. These results indicate that P. brevitarsis effectively suppresses testosterone‐induced development of BPH, and thus, is a potential therapeutic agent for BPH.
Treatment with Protaetia brevitarsis seulensis extracts (PBE) reduced prostate weight, dihydrotestosterone levels of benign prostatic hyperplasia (BPH) animals. Furthermore, PBE attenuated the testosterone‐induced hyperplasia and proliferation of prostatic epithelial cells. 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it has been shown to possess various pharmacological effects such as antibacterial and antioxidant activities. In this study, we investigated the effects of P. brevitarsis on a testosterone‐induced benign prostatic hyperplasia (BPH) rat model. To establish the BPH model, the animals were administered a subcutaneous injection of testosterone daily for 28 days. P. brevitarsis was administered by oral gavage at doses of 12.5, 25, and 50 mg/kg for 28 days, along with testosterone injection. P. brevitarsis treatment markedly decreased the absolute and relative prostate weight of BPH animals. The levels of dihydrotestosterone was reduced in P. brevitarsis‐treated animals compared to those in the BPH animals. Histological analysis of the prostate showed that P. brevitarsis treatment effectively suppressed the testosterone‐induced hyperplasia of prostatic epithelial cells, which was accompanied by reductions in the PCNA and Ki‐67 expressions in prostatic tissues. These results indicate that P. brevitarsis effectively suppresses testosterone‐induced development of BPH, and thus, is a potential therapeutic agent for BPH.
Treatment with Protaetia brevitarsis seulensis extracts (PBE) reduced prostate weight, dihydrotestosterone levels of benign prostatic hyperplasia (BPH) animals. Furthermore, PBE attenuated the testosterone‐induced hyperplasia and proliferation of prostatic epithelial cells. These results indicate that P. brevitarsis is a potential therapeutic agent for BPH.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>34646508</pmid><doi>10.1002/fsn3.2460</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2180-4860</orcidid><orcidid>https://orcid.org/0000-0003-4414-3495</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic receptors Androgens Animals Antioxidants benign prostatic hyperplasia Chemical compounds Dihydrotestosterone Epithelial cells Epithelium Genital diseases Hyperplasia Injection Laboratories Medicine Original Research Pharmacology Prostate Protaetia brevitarsis Protaetia brevitarsis seulensison Proteins Testosterone |
| title | Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats |
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