W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34

Spinocerebellar ataxia (SCA) is a neurodegenerative disorder characterized by ataxia and cerebellar atrophy. A number of different mutations gives rise to different types of SCA with characteristic ages of onset, symptomatology, and rates of progression. SCA type 34 (SCA34) is caused by mutations in...

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Veröffentlicht in:	Molecular neurobiology 2021-10, Vol.58 (10), p.4921-4943
Hauptverfasser:	Nagaraja, Raghavendra Y., Sherry, David M., Fessler, Jennifer L., Stiles, Megan A., Li, Feng, Multani, Karanpreet, Orock, Albert, Ahmad, Mohiuddin, Brush, Richard S., Anderson, Robert E., Agbaga, Martin-Paul, Deák, Ferenc
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Anatomy Animals Ataxia Atrophy Biomedical and Life Sciences Biomedicine Brain architecture Cell Biology Cerebellar plasticity Cerebellum Cerebellum - pathology Eye Proteins - genetics Fatty acids Female Long-term depression Long-term potentiation Male Membrane Proteins - genetics Motor Disorders - genetics Motor Disorders - pathology Mutants Mutation Mutation - genetics Nerve Fibers, Myelinated - pathology Neurobiology Neurodegeneration Neurodegenerative diseases Neurology Neuronal Plasticity - physiology Neurosciences Organ Culture Techniques Polyunsaturated fatty acids Purkinje cells Rats Rats, Long-Evans Rats, Transgenic Retina Skin tests Spinocerebellar Ataxias - genetics Spinocerebellar Ataxias - pathology Synapses Synaptic depression Synaptic plasticity Synchronization
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