PEGylated Oligothioetheramide Prodrugs Activated by Host Serum Proteases

Due to the increasing prominence of antibiotic resistance, novel drug discovery and delivery approaches targeting bacteria are essential. In this work we evaluate a prodrug design to improve the cytotoxic profile of polycationic oligothioetheramides (oligoTEAs), which are promising antimicrobials. H...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2021-09, Vol.22 (17), p.2697-2702
Hauptverfasser:	Artim, Christine M., Kunala, Manisha, O'Leary, Meghan K., Alabi, Christopher A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotic resistance Antibiotics Antimicrobial agents antimicrobials Cleavage Cytotoxicity Drugs Humans Microbial Sensitivity Tests MRSA PEG Peptide Hydrolases - chemistry Peptide Hydrolases - metabolism Peptides Polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology polymers Prodrugs Prodrugs - chemical synthesis Prodrugs - chemistry Prodrugs - metabolism Prodrugs - pharmacology Proteolysis Thioamides - chemistry Thioamides - pharmacology Toxicity
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