The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels

Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or location along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex of type 2 diabetic mice with cognitive impairment. To determi...

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Veröffentlicht in:	eNeuro 2021-09, Vol.8 (5), p.ENEURO.0201-21.2021
Hauptverfasser:	Griggs, Ryan B, Nguyen, Duc V M, Yermakov, Leonid M, Jaber, Jeneane M, Shelby, Jennae N, Steinbrunner, Josef K, Miller, John A, Gonzalez-Islas, Carlos, Wenner, Peter, Susuki, Keiichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axon Initial Segment Diabetes Mellitus, Experimental Diabetes Mellitus, Type 2 Female Male Mice Neurons New Research Pyruvaldehyde
Online-Zugang:	Volltext
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