Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study
We aimed to evaluate the diagnostic agreement between radiofrequency (RF) intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for thin-cap fibroatheroma (TCFA) in non-infarct-related coronary arteries (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI). I...
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| Veröffentlicht in: | The International Journal of Cardiovascular Imaging 2021-10, Vol.37 (10), p.2839-2847 |
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| creator | Ueki, Yasushi Yamaji, Kyohei Losdat, Sylvain Karagiannis, Alexios Taniwaki, Masanori Roffi, Marco Otsuka, Tatsuhiko Koskinas, Konstantinos C. Holmvang, Lene Maldonado, Rafaela Pedrazzini, Giovanni Radu, Maria D. Dijkstra, Jouke Windecker, Stephan Garcia-Garcia, Hector M. Räber, Lorenz |
| description | We aimed to evaluate the diagnostic agreement between radiofrequency (RF) intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for thin-cap fibroatheroma (TCFA) in non-infarct-related coronary arteries (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI). In the Integrated Biomarker Imaging Study (IBIS-4), 103 STEMI patients underwent OCT and RF-IVUS imaging of non-IRA after successful primary percutaneous coronary intervention and at 13-month follow-up. A coronary lesion was defined as a segment with ≥ 3 consecutive frames (≈1.2 mm) with plaque burden ≥ 40% as assessed by grayscale IVUS. RF-IVUS-derived TCFA was defined as a lesion with > 10% confluent necrotic core abutting to the lumen in > 10% of the circumference. OCT-TCFA was defined by a minimum cap thickness |
| doi_str_mv | 10.1007/s10554-021-02272-6 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8494667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2549689856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-9a3f61afe0d1dfaf26a6345097282ceb1601a34529f9220695904e41b25f739c3</originalsourceid><addsrcrecordid>eNp9Ustu1DAUjRCIlsIPsECW2LAJOI7jjFkglfIaqRILYG3dca4TV4kdbGeq-V2-BKdTymPBwrJ977nnvk5RPK3oy4rS9lWsaNPwkrIqH9ayUtwrTqumrUva8vr--haybFrJT4pHMV5RShll9cPipOasFk1LT4sf72zUPnTgNBLrSBqQdBZ652OymkCMGOOELhFvyH4ZHQbYjUjmEb4vGMkO0zWiIwE6603AbHT6kJlSgD1EvYwQyDLmX_SL68geQ1wi8XNmh5FoP2DANXfyk-8DzMOBwORdT2ZINueN5NqmgYBeEpLp4DWEXN-YMxgIOlnvXud3tP2QoSb46aaF7dvtl5KTmJbu8Lh4YGCM-OT2Piu-fXj_9eJTefn54_bi_LLUvOWplFAbUYFB2lWdAcMEiJo3VLZswzTuKkEryAYmjWSMCtlIypFXO9aYtpa6PiveHHnnZTdhp3GdwajmYCcIB-XBqr89zg6q93u14ZIL0WaCF7cEwa_DTWrKy8FxBId-iYo1XIqN3DQiQ5__A73yS3C5vYzKC28p36wodkTp4GMMaO6KqahaJaSOElJZQupGQmoNevZnG3chvzSTAfURELPL9Rh-5_4P7U9hc9mV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2579470486</pqid></control><display><type>article</type><title>Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Ueki, Yasushi ; Yamaji, Kyohei ; Losdat, Sylvain ; Karagiannis, Alexios ; Taniwaki, Masanori ; Roffi, Marco ; Otsuka, Tatsuhiko ; Koskinas, Konstantinos C. ; Holmvang, Lene ; Maldonado, Rafaela ; Pedrazzini, Giovanni ; Radu, Maria D. ; Dijkstra, Jouke ; Windecker, Stephan ; Garcia-Garcia, Hector M. ; Räber, Lorenz</creator><creatorcontrib>Ueki, Yasushi ; Yamaji, Kyohei ; Losdat, Sylvain ; Karagiannis, Alexios ; Taniwaki, Masanori ; Roffi, Marco ; Otsuka, Tatsuhiko ; Koskinas, Konstantinos C. ; Holmvang, Lene ; Maldonado, Rafaela ; Pedrazzini, Giovanni ; Radu, Maria D. ; Dijkstra, Jouke ; Windecker, Stephan ; Garcia-Garcia, Hector M. ; Räber, Lorenz</creatorcontrib><description>We aimed to evaluate the diagnostic agreement between radiofrequency (RF) intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for thin-cap fibroatheroma (TCFA) in non-infarct-related coronary arteries (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI). In the Integrated Biomarker Imaging Study (IBIS-4), 103 STEMI patients underwent OCT and RF-IVUS imaging of non-IRA after successful primary percutaneous coronary intervention and at 13-month follow-up. A coronary lesion was defined as a segment with ≥ 3 consecutive frames (≈1.2 mm) with plaque burden ≥ 40% as assessed by grayscale IVUS. RF-IVUS-derived TCFA was defined as a lesion with > 10% confluent necrotic core abutting to the lumen in > 10% of the circumference. OCT-TCFA was defined by a minimum cap thickness < 65 μm. The two modalities were matched based on anatomical landmarks using a dedicated matching software. Using grayscale IVUS, we identified 276 lesions at baseline (N = 146) and follow-up (N = 130). Using RF-IVUS, 208 lesions (75.4%) were classified as TCFA. Among them, OCT identified 14 (6.7%) TCFA, 60 (28.8%) thick-cap fibroatheroma (ThCFA), and 134 (64.4%) non-fibroatheroma. All OCT-TCFA (n = 14) were confirmed as RF-TCFA. The concordance rate between RF-IVUS and OCT for TCFA diagnosis was 29.7%. The reasons for discordance were: OCT-ThCFA (25.8%); OCT-fibrous plaque (34.0%); attenuation due to calcium (23.2%); attenuation due to macrophage (10.3%); no significant attenuation (6.7%). There was a notable discordance in the diagnostic assessment of TCFA between RF-IVUS and OCT. The majority of RF-derived TCFA were not categorized as fibroatheroma using OCT, while all OCT-TCFA were classified as TCFA by RF-IVUS.
ClinicalTrials.gov Identifier
NCT00962416.</description><identifier>ISSN: 1569-5794</identifier><identifier>EISSN: 1573-0743</identifier><identifier>EISSN: 1875-8312</identifier><identifier>DOI: 10.1007/s10554-021-02272-6</identifier><identifier>PMID: 34236570</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Arteries ; Attenuation ; Biomarkers ; Cardiac Imaging ; Cardiology ; Coronary artery ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - therapy ; Coronary Vessels - diagnostic imaging ; Discordance ; Gray scale ; Heart attacks ; Humans ; Imaging ; Lesions ; Macrophages ; Medical imaging ; Medicine ; Medicine & Public Health ; Myocardial Infarction ; Optical Coherence Tomography ; Original Paper ; Plaque, Atherosclerotic ; Plaques ; Predictive Value of Tests ; Radio frequency ; Radiology ; Segments ; Stents ; Tomography ; Tomography, Optical Coherence ; Ultrasonic imaging ; Ultrasonography, Interventional ; Ultrasound</subject><ispartof>The International Journal of Cardiovascular Imaging, 2021-10, Vol.37 (10), p.2839-2847</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9a3f61afe0d1dfaf26a6345097282ceb1601a34529f9220695904e41b25f739c3</citedby><cites>FETCH-LOGICAL-c474t-9a3f61afe0d1dfaf26a6345097282ceb1601a34529f9220695904e41b25f739c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10554-021-02272-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10554-021-02272-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34236570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ueki, Yasushi</creatorcontrib><creatorcontrib>Yamaji, Kyohei</creatorcontrib><creatorcontrib>Losdat, Sylvain</creatorcontrib><creatorcontrib>Karagiannis, Alexios</creatorcontrib><creatorcontrib>Taniwaki, Masanori</creatorcontrib><creatorcontrib>Roffi, Marco</creatorcontrib><creatorcontrib>Otsuka, Tatsuhiko</creatorcontrib><creatorcontrib>Koskinas, Konstantinos C.</creatorcontrib><creatorcontrib>Holmvang, Lene</creatorcontrib><creatorcontrib>Maldonado, Rafaela</creatorcontrib><creatorcontrib>Pedrazzini, Giovanni</creatorcontrib><creatorcontrib>Radu, Maria D.</creatorcontrib><creatorcontrib>Dijkstra, Jouke</creatorcontrib><creatorcontrib>Windecker, Stephan</creatorcontrib><creatorcontrib>Garcia-Garcia, Hector M.</creatorcontrib><creatorcontrib>Räber, Lorenz</creatorcontrib><title>Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study</title><title>The International Journal of Cardiovascular Imaging</title><addtitle>Int J Cardiovasc Imaging</addtitle><addtitle>Int J Cardiovasc Imaging</addtitle><description>We aimed to evaluate the diagnostic agreement between radiofrequency (RF) intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for thin-cap fibroatheroma (TCFA) in non-infarct-related coronary arteries (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI). In the Integrated Biomarker Imaging Study (IBIS-4), 103 STEMI patients underwent OCT and RF-IVUS imaging of non-IRA after successful primary percutaneous coronary intervention and at 13-month follow-up. A coronary lesion was defined as a segment with ≥ 3 consecutive frames (≈1.2 mm) with plaque burden ≥ 40% as assessed by grayscale IVUS. RF-IVUS-derived TCFA was defined as a lesion with > 10% confluent necrotic core abutting to the lumen in > 10% of the circumference. OCT-TCFA was defined by a minimum cap thickness < 65 μm. The two modalities were matched based on anatomical landmarks using a dedicated matching software. Using grayscale IVUS, we identified 276 lesions at baseline (N = 146) and follow-up (N = 130). Using RF-IVUS, 208 lesions (75.4%) were classified as TCFA. Among them, OCT identified 14 (6.7%) TCFA, 60 (28.8%) thick-cap fibroatheroma (ThCFA), and 134 (64.4%) non-fibroatheroma. All OCT-TCFA (n = 14) were confirmed as RF-TCFA. The concordance rate between RF-IVUS and OCT for TCFA diagnosis was 29.7%. The reasons for discordance were: OCT-ThCFA (25.8%); OCT-fibrous plaque (34.0%); attenuation due to calcium (23.2%); attenuation due to macrophage (10.3%); no significant attenuation (6.7%). There was a notable discordance in the diagnostic assessment of TCFA between RF-IVUS and OCT. The majority of RF-derived TCFA were not categorized as fibroatheroma using OCT, while all OCT-TCFA were classified as TCFA by RF-IVUS.
ClinicalTrials.gov Identifier
NCT00962416.</description><subject>Arteries</subject><subject>Attenuation</subject><subject>Biomarkers</subject><subject>Cardiac Imaging</subject><subject>Cardiology</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Discordance</subject><subject>Gray scale</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Imaging</subject><subject>Lesions</subject><subject>Macrophages</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myocardial Infarction</subject><subject>Optical Coherence Tomography</subject><subject>Original Paper</subject><subject>Plaque, Atherosclerotic</subject><subject>Plaques</subject><subject>Predictive Value of Tests</subject><subject>Radio frequency</subject><subject>Radiology</subject><subject>Segments</subject><subject>Stents</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography, Interventional</subject><subject>Ultrasound</subject><issn>1569-5794</issn><issn>1573-0743</issn><issn>1875-8312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9Ustu1DAUjRCIlsIPsECW2LAJOI7jjFkglfIaqRILYG3dca4TV4kdbGeq-V2-BKdTymPBwrJ977nnvk5RPK3oy4rS9lWsaNPwkrIqH9ayUtwrTqumrUva8vr--haybFrJT4pHMV5RShll9cPipOasFk1LT4sf72zUPnTgNBLrSBqQdBZ652OymkCMGOOELhFvyH4ZHQbYjUjmEb4vGMkO0zWiIwE6603AbHT6kJlSgD1EvYwQyDLmX_SL68geQ1wi8XNmh5FoP2DANXfyk-8DzMOBwORdT2ZINueN5NqmgYBeEpLp4DWEXN-YMxgIOlnvXud3tP2QoSb46aaF7dvtl5KTmJbu8Lh4YGCM-OT2Piu-fXj_9eJTefn54_bi_LLUvOWplFAbUYFB2lWdAcMEiJo3VLZswzTuKkEryAYmjWSMCtlIypFXO9aYtpa6PiveHHnnZTdhp3GdwajmYCcIB-XBqr89zg6q93u14ZIL0WaCF7cEwa_DTWrKy8FxBId-iYo1XIqN3DQiQ5__A73yS3C5vYzKC28p36wodkTp4GMMaO6KqahaJaSOElJZQupGQmoNevZnG3chvzSTAfURELPL9Rh-5_4P7U9hc9mV</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Ueki, Yasushi</creator><creator>Yamaji, Kyohei</creator><creator>Losdat, Sylvain</creator><creator>Karagiannis, Alexios</creator><creator>Taniwaki, Masanori</creator><creator>Roffi, Marco</creator><creator>Otsuka, Tatsuhiko</creator><creator>Koskinas, Konstantinos C.</creator><creator>Holmvang, Lene</creator><creator>Maldonado, Rafaela</creator><creator>Pedrazzini, Giovanni</creator><creator>Radu, Maria D.</creator><creator>Dijkstra, Jouke</creator><creator>Windecker, Stephan</creator><creator>Garcia-Garcia, Hector M.</creator><creator>Räber, Lorenz</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211001</creationdate><title>Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study</title><author>Ueki, Yasushi ; Yamaji, Kyohei ; Losdat, Sylvain ; Karagiannis, Alexios ; Taniwaki, Masanori ; Roffi, Marco ; Otsuka, Tatsuhiko ; Koskinas, Konstantinos C. ; Holmvang, Lene ; Maldonado, Rafaela ; Pedrazzini, Giovanni ; Radu, Maria D. ; Dijkstra, Jouke ; Windecker, Stephan ; Garcia-Garcia, Hector M. ; Räber, Lorenz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9a3f61afe0d1dfaf26a6345097282ceb1601a34529f9220695904e41b25f739c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Arteries</topic><topic>Attenuation</topic><topic>Biomarkers</topic><topic>Cardiac Imaging</topic><topic>Cardiology</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Discordance</topic><topic>Gray scale</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Imaging</topic><topic>Lesions</topic><topic>Macrophages</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myocardial Infarction</topic><topic>Optical Coherence Tomography</topic><topic>Original Paper</topic><topic>Plaque, Atherosclerotic</topic><topic>Plaques</topic><topic>Predictive Value of Tests</topic><topic>Radio frequency</topic><topic>Radiology</topic><topic>Segments</topic><topic>Stents</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography, Interventional</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ueki, Yasushi</creatorcontrib><creatorcontrib>Yamaji, Kyohei</creatorcontrib><creatorcontrib>Losdat, Sylvain</creatorcontrib><creatorcontrib>Karagiannis, Alexios</creatorcontrib><creatorcontrib>Taniwaki, Masanori</creatorcontrib><creatorcontrib>Roffi, Marco</creatorcontrib><creatorcontrib>Otsuka, Tatsuhiko</creatorcontrib><creatorcontrib>Koskinas, Konstantinos C.</creatorcontrib><creatorcontrib>Holmvang, Lene</creatorcontrib><creatorcontrib>Maldonado, Rafaela</creatorcontrib><creatorcontrib>Pedrazzini, Giovanni</creatorcontrib><creatorcontrib>Radu, Maria D.</creatorcontrib><creatorcontrib>Dijkstra, Jouke</creatorcontrib><creatorcontrib>Windecker, Stephan</creatorcontrib><creatorcontrib>Garcia-Garcia, Hector M.</creatorcontrib><creatorcontrib>Räber, Lorenz</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The International Journal of Cardiovascular Imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ueki, Yasushi</au><au>Yamaji, Kyohei</au><au>Losdat, Sylvain</au><au>Karagiannis, Alexios</au><au>Taniwaki, Masanori</au><au>Roffi, Marco</au><au>Otsuka, Tatsuhiko</au><au>Koskinas, Konstantinos C.</au><au>Holmvang, Lene</au><au>Maldonado, Rafaela</au><au>Pedrazzini, Giovanni</au><au>Radu, Maria D.</au><au>Dijkstra, Jouke</au><au>Windecker, Stephan</au><au>Garcia-Garcia, Hector M.</au><au>Räber, Lorenz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study</atitle><jtitle>The International Journal of Cardiovascular Imaging</jtitle><stitle>Int J Cardiovasc Imaging</stitle><addtitle>Int J Cardiovasc Imaging</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>37</volume><issue>10</issue><spage>2839</spage><epage>2847</epage><pages>2839-2847</pages><issn>1569-5794</issn><eissn>1573-0743</eissn><eissn>1875-8312</eissn><abstract>We aimed to evaluate the diagnostic agreement between radiofrequency (RF) intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for thin-cap fibroatheroma (TCFA) in non-infarct-related coronary arteries (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI). In the Integrated Biomarker Imaging Study (IBIS-4), 103 STEMI patients underwent OCT and RF-IVUS imaging of non-IRA after successful primary percutaneous coronary intervention and at 13-month follow-up. A coronary lesion was defined as a segment with ≥ 3 consecutive frames (≈1.2 mm) with plaque burden ≥ 40% as assessed by grayscale IVUS. RF-IVUS-derived TCFA was defined as a lesion with > 10% confluent necrotic core abutting to the lumen in > 10% of the circumference. OCT-TCFA was defined by a minimum cap thickness < 65 μm. The two modalities were matched based on anatomical landmarks using a dedicated matching software. Using grayscale IVUS, we identified 276 lesions at baseline (N = 146) and follow-up (N = 130). Using RF-IVUS, 208 lesions (75.4%) were classified as TCFA. Among them, OCT identified 14 (6.7%) TCFA, 60 (28.8%) thick-cap fibroatheroma (ThCFA), and 134 (64.4%) non-fibroatheroma. All OCT-TCFA (n = 14) were confirmed as RF-TCFA. The concordance rate between RF-IVUS and OCT for TCFA diagnosis was 29.7%. The reasons for discordance were: OCT-ThCFA (25.8%); OCT-fibrous plaque (34.0%); attenuation due to calcium (23.2%); attenuation due to macrophage (10.3%); no significant attenuation (6.7%). There was a notable discordance in the diagnostic assessment of TCFA between RF-IVUS and OCT. The majority of RF-derived TCFA were not categorized as fibroatheroma using OCT, while all OCT-TCFA were classified as TCFA by RF-IVUS.
ClinicalTrials.gov Identifier
NCT00962416.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>34236570</pmid><doi>10.1007/s10554-021-02272-6</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Arteries Attenuation Biomarkers Cardiac Imaging Cardiology Coronary artery Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - therapy Coronary Vessels - diagnostic imaging Discordance Gray scale Heart attacks Humans Imaging Lesions Macrophages Medical imaging Medicine Medicine & Public Health Myocardial Infarction Optical Coherence Tomography Original Paper Plaque, Atherosclerotic Plaques Predictive Value of Tests Radio frequency Radiology Segments Stents Tomography Tomography, Optical Coherence Ultrasonic imaging Ultrasonography, Interventional Ultrasound |
| title | Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study |
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