Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release

The alternative PCNA loader containing CTF18-DCC1-CTF8 facilitates sister chromatid cohesion (SCC) by poorly defined mechanisms. Here we found that in DT40 cells, CTF18 acts complementarily with the Warsaw breakage syndrome DDX11 helicase in mediating SCC and proliferation. We uncover that the letha...

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Veröffentlicht in:	Genes & development 2021-10, Vol.35 (19-20), p.1368-1382
Hauptverfasser:	Kawasumi, Ryotaro, Abe, Takuya, Psakhye, Ivan, Miyata, Keiji, Hirota, Kouji, Branzei, Dana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - genetics Chromatids - genetics Chromosomal Proteins, Non-Histone - genetics Cohesins Research Paper Vertebrates - genetics
Online-Zugang:	Volltext
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