Characterization of PCSK9 in the Blood and Skin of Psoriasis

Mechanisms explaining the link between psoriasis, a proinflammatory condition, and cardiovascular disease are not fully known. PCSK9 is predominantly expressed in hepatocytes as a critical regulator of lipid metabolism, and clinical trials targeting PCSK9 reduce cardiovascular disease. Independent o...

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Veröffentlicht in:	Journal of investigative dermatology 2021-02, Vol.141 (2), p.308-315
Hauptverfasser:	Garshick, Michael S., Baumer, Yvonne, Dey, Amit K., Grattan, Ryan, Ng, Qimin, Teague, Heather L., Yu, Zu-Xi, Chen, Marcus Y., Tawil, Michael, Barrett, Tessa J., Underberg, James, Fisher, Edward A., Krueger, James, Powell-Wiley, Tiffany M., Playford, Martin P., Berger, Jeffrey S., Mehta, Nehal N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Atherosclerosis - etiology Cardiovascular Diseases - etiology Endothelium, Vascular - pathology Female Humans Male Mice Middle Aged Proprotein Convertase 9 - blood Proprotein Convertase 9 - physiology Psoriasis - etiology Skin - enzymology
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