Paracrine interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration
Interleukin-8 (IL-8) promotes cell homing and angiogenesis, but its effects on activating human bone marrow mesenchymal stem cells (BMSCs) and promoting angiogenesis are unclear. We used bioinformatics to predict these processes. In vitro, BMSCs were stimulated in a high-glucose (HG) environment wit...
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| creator | Wang, Lulu Li, Yongtao Zhang, Xiaodong Liu, Na Shen, Shiyang Sun, Shizhu Jiang, Yang Li, Penghui Jin, Haifeng Shen, Lei |
| description | Interleukin-8 (IL-8) promotes cell homing and angiogenesis, but its effects on activating human bone marrow mesenchymal stem cells (BMSCs) and promoting angiogenesis are unclear. We used bioinformatics to predict these processes. In vitro, BMSCs were stimulated in a high-glucose (HG) environment with 50 or 100 μg/ml IL-8 was used as the IL-8 group. A total of 5 μmol/l Triciribine was added to the two IL-8 groups as the Akt inhibitor group. Cultured human umbilical vein endothelial cells (HUVECs) were cultured in BMSCs conditioned medium (CM). The changes in proliferation, apoptosis, migration ability and levels of VEGF and IL-6 in HUVECs were observed in each group. Seventy processes and 26 pathways were involved in vascular development, through which IL-8 affected BMSCs. Compared with the HG control group, HUVEC proliferation absorbance value (A value), Gap closure rate, and Transwell cell migration rate in the IL-8 50 and IL-8 100 CM groups were significantly increased (P |
| doi_str_mv | 10.1042/BSR20210198 |
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We used bioinformatics to predict these processes. In vitro, BMSCs were stimulated in a high-glucose (HG) environment with 50 or 100 μg/ml IL-8 was used as the IL-8 group. A total of 5 μmol/l Triciribine was added to the two IL-8 groups as the Akt inhibitor group. Cultured human umbilical vein endothelial cells (HUVECs) were cultured in BMSCs conditioned medium (CM). The changes in proliferation, apoptosis, migration ability and levels of VEGF and IL-6 in HUVECs were observed in each group. Seventy processes and 26 pathways were involved in vascular development, through which IL-8 affected BMSCs. Compared with the HG control group, HUVEC proliferation absorbance value (A value), Gap closure rate, and Transwell cell migration rate in the IL-8 50 and IL-8 100 CM groups were significantly increased (P<0.01, n=30). However, HUVEC apoptosis was significantly decreased (P<0.01, n=30). Akt and phospho-Akt (P-Akt) protein contents in lysates of BMSCs treated with IL-8, as well as VEGF and IL-6 protein contents in the supernatant of BMSCs treated with IL-8, were all highly expressed (P<0.01, n=15). These analyses confirmed that IL-8 promoted the expression of 41 core proteins in BMSCs through the PI3K Akt pathway, which could promote the proliferation and migration of vascular endothelial cells. Therefore, in an HG environment, IL-8 activated the Akt signaling pathway, promoted paracrine mechanisms of BMSCs, and improved the proliferation and migration of HUVECs.</description><identifier>ISSN: 0144-8463</identifier><identifier>EISSN: 1573-4935</identifier><identifier>DOI: 10.1042/BSR20210198</identifier><identifier>PMID: 33843989</identifier><language>eng</language><publisher>England: Portland Press Ltd The Biochemical Society</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Angiogenesis ; Apoptosis ; Bioinformatics ; Bone marrow ; Cell Cycle, Growth & Proliferation ; Cell migration ; Cell Migration, Adhesion & Morphology ; Cell proliferation ; Chemokines ; Cytokines ; Diabetes ; Endothelial cells ; Gene expression ; Homing behavior ; Interleukin 6 ; Interleukin 8 ; Interleukins ; Lysates ; Mesenchymal stem cells ; Ontology ; Paracrine signalling ; Proteins ; Signal transduction ; Stem Cells ; Ulcers ; Umbilical vein ; Vascular endothelial growth factor ; Wound healing</subject><ispartof>Bioscience reports, 2021-05, Vol.41 (5)</ispartof><rights>2021 The Author(s).</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 The Author(s). 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-9cf5317d916e3ae7f5207c7acef8d403d56b1a353645648492a83516e3cec9583</citedby><cites>FETCH-LOGICAL-c409t-9cf5317d916e3ae7f5207c7acef8d403d56b1a353645648492a83516e3cec9583</cites><orcidid>0000-0001-6182-3682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493446/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2956879869?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,12726,12755,21369,21370,21371,21372,21373,23237,27905,27906,33433,33434,33511,33512,33684,33685,33725,33726,33986,33987,34295,34296,34315,34316,36246,36247,43597,43640,43768,43786,43934,44048,44054,44385,53772,53774,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33843989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Lulu</creatorcontrib><creatorcontrib>Li, Yongtao</creatorcontrib><creatorcontrib>Zhang, Xiaodong</creatorcontrib><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Shen, Shiyang</creatorcontrib><creatorcontrib>Sun, Shizhu</creatorcontrib><creatorcontrib>Jiang, Yang</creatorcontrib><creatorcontrib>Li, Penghui</creatorcontrib><creatorcontrib>Jin, Haifeng</creatorcontrib><creatorcontrib>Shen, Lei</creatorcontrib><title>Paracrine interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration</title><title>Bioscience reports</title><addtitle>Biosci Rep</addtitle><description>Interleukin-8 (IL-8) promotes cell homing and angiogenesis, but its effects on activating human bone marrow mesenchymal stem cells (BMSCs) and promoting angiogenesis are unclear. We used bioinformatics to predict these processes. In vitro, BMSCs were stimulated in a high-glucose (HG) environment with 50 or 100 μg/ml IL-8 was used as the IL-8 group. A total of 5 μmol/l Triciribine was added to the two IL-8 groups as the Akt inhibitor group. Cultured human umbilical vein endothelial cells (HUVECs) were cultured in BMSCs conditioned medium (CM). The changes in proliferation, apoptosis, migration ability and levels of VEGF and IL-6 in HUVECs were observed in each group. Seventy processes and 26 pathways were involved in vascular development, through which IL-8 affected BMSCs. Compared with the HG control group, HUVEC proliferation absorbance value (A value), Gap closure rate, and Transwell cell migration rate in the IL-8 50 and IL-8 100 CM groups were significantly increased (P<0.01, n=30). However, HUVEC apoptosis was significantly decreased (P<0.01, n=30). Akt and phospho-Akt (P-Akt) protein contents in lysates of BMSCs treated with IL-8, as well as VEGF and IL-6 protein contents in the supernatant of BMSCs treated with IL-8, were all highly expressed (P<0.01, n=15). These analyses confirmed that IL-8 promoted the expression of 41 core proteins in BMSCs through the PI3K Akt pathway, which could promote the proliferation and migration of vascular endothelial cells. Therefore, in an HG environment, IL-8 activated the Akt signaling pathway, promoted paracrine mechanisms of BMSCs, and improved the proliferation and migration of HUVECs.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Bioinformatics</subject><subject>Bone marrow</subject><subject>Cell Cycle, Growth & Proliferation</subject><subject>Cell migration</subject><subject>Cell Migration, Adhesion & Morphology</subject><subject>Cell proliferation</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Endothelial cells</subject><subject>Gene expression</subject><subject>Homing behavior</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Interleukins</subject><subject>Lysates</subject><subject>Mesenchymal stem cells</subject><subject>Ontology</subject><subject>Paracrine signalling</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Stem Cells</subject><subject>Ulcers</subject><subject>Umbilical vein</subject><subject>Vascular endothelial growth factor</subject><subject>Wound 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interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration</title><author>Wang, Lulu ; Li, Yongtao ; Zhang, Xiaodong ; Liu, Na ; Shen, Shiyang ; Sun, Shizhu ; Jiang, Yang ; Li, Penghui ; Jin, Haifeng ; Shen, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-9cf5317d916e3ae7f5207c7acef8d403d56b1a353645648492a83516e3cec9583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Angiogenesis</topic><topic>Apoptosis</topic><topic>Bioinformatics</topic><topic>Bone marrow</topic><topic>Cell Cycle, Growth & Proliferation</topic><topic>Cell migration</topic><topic>Cell Migration, Adhesion & Morphology</topic><topic>Cell proliferation</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Endothelial cells</topic><topic>Gene expression</topic><topic>Homing behavior</topic><topic>Interleukin 6</topic><topic>Interleukin 8</topic><topic>Interleukins</topic><topic>Lysates</topic><topic>Mesenchymal stem cells</topic><topic>Ontology</topic><topic>Paracrine signalling</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>Stem Cells</topic><topic>Ulcers</topic><topic>Umbilical vein</topic><topic>Vascular endothelial growth factor</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lulu</creatorcontrib><creatorcontrib>Li, Yongtao</creatorcontrib><creatorcontrib>Zhang, Xiaodong</creatorcontrib><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Shen, Shiyang</creatorcontrib><creatorcontrib>Sun, Shizhu</creatorcontrib><creatorcontrib>Jiang, Yang</creatorcontrib><creatorcontrib>Li, Penghui</creatorcontrib><creatorcontrib>Jin, Haifeng</creatorcontrib><creatorcontrib>Shen, Lei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium 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Rep</addtitle><date>2021-05-28</date><risdate>2021</risdate><volume>41</volume><issue>5</issue><issn>0144-8463</issn><eissn>1573-4935</eissn><abstract>Interleukin-8 (IL-8) promotes cell homing and angiogenesis, but its effects on activating human bone marrow mesenchymal stem cells (BMSCs) and promoting angiogenesis are unclear. We used bioinformatics to predict these processes. In vitro, BMSCs were stimulated in a high-glucose (HG) environment with 50 or 100 μg/ml IL-8 was used as the IL-8 group. A total of 5 μmol/l Triciribine was added to the two IL-8 groups as the Akt inhibitor group. Cultured human umbilical vein endothelial cells (HUVECs) were cultured in BMSCs conditioned medium (CM). The changes in proliferation, apoptosis, migration ability and levels of VEGF and IL-6 in HUVECs were observed in each group. Seventy processes and 26 pathways were involved in vascular development, through which IL-8 affected BMSCs. Compared with the HG control group, HUVEC proliferation absorbance value (A value), Gap closure rate, and Transwell cell migration rate in the IL-8 50 and IL-8 100 CM groups were significantly increased (P<0.01, n=30). However, HUVEC apoptosis was significantly decreased (P<0.01, n=30). Akt and phospho-Akt (P-Akt) protein contents in lysates of BMSCs treated with IL-8, as well as VEGF and IL-6 protein contents in the supernatant of BMSCs treated with IL-8, were all highly expressed (P<0.01, n=15). These analyses confirmed that IL-8 promoted the expression of 41 core proteins in BMSCs through the PI3K Akt pathway, which could promote the proliferation and migration of vascular endothelial cells. Therefore, in an HG environment, IL-8 activated the Akt signaling pathway, promoted paracrine mechanisms of BMSCs, and improved the proliferation and migration of HUVECs.</abstract><cop>England</cop><pub>Portland Press Ltd The Biochemical Society</pub><pmid>33843989</pmid><doi>10.1042/BSR20210198</doi><orcidid>https://orcid.org/0000-0001-6182-3682</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Apoptosis Bioinformatics Bone marrow Cell Cycle, Growth & Proliferation Cell migration Cell Migration, Adhesion & Morphology Cell proliferation Chemokines Cytokines Diabetes Endothelial cells Gene expression Homing behavior Interleukin 6 Interleukin 8 Interleukins Lysates Mesenchymal stem cells Ontology Paracrine signalling Proteins Signal transduction Stem Cells Ulcers Umbilical vein Vascular endothelial growth factor Wound healing |
| title | Paracrine interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration |
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