Deletion of Nrip1 delays skin aging by reducing adipose-derived mesenchymal stem cells (ADMSCs) senescence, and maintaining ADMSCs quiescence

Our previous studies found that deletion of nuclear receptor interacting protein 1 ( Nrip1 ) extended longevity in female mice and delayed cell senescence. The current study investigates the role of NRIP1 in regulating functions of adipose-derived mesenchymal stem cells (ADMSCs) and explores the mec...

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Veröffentlicht in:	GeroScience 2021-08, Vol.43 (4), p.1815-1833
Hauptverfasser:	Hu, Yu, Zhu, Yun, Gerber, Skyler D., Osland, Jared M., Chen, Min, Rao, Krishna A., Gu, Heng, Yuan, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis Adipose tissue Aging Animals Apoptosis Biomedical and Life Sciences Cell Biology Cell proliferation Cellular Senescence - genetics Dermis Female Geriatrics/Gerontology Insulin-like growth factor I Interleukin 1 Interleukin 6 Life Sciences Mesenchymal Stem Cells Mice Mice, Inbred C57BL Molecular Medicine Nuclear Receptor Interacting Protein 1 Original Original Article p53 Protein Phenotypes Senescence Skin Skin Aging - genetics Stem cell transplantation Stem cells TOR protein
Online-Zugang:	Volltext
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