Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups
It was still unclear how homocysteine (Hcy) levels and cognitive deficits change in patients with schizophrenia of various ages. The present article attempts to assess the relationship between Hcy levels and cognitive deficits in patients with schizophrenia across age groups, especially in young peo...
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| Veröffentlicht in: | Scientific reports 2021-10, Vol.11 (1), p.19716-19716, Article 19716 |
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| description | It was still unclear how homocysteine (Hcy) levels and cognitive deficits change in patients with schizophrenia of various ages. The present article attempts to assess the relationship between Hcy levels and cognitive deficits in patients with schizophrenia across age groups, especially in young people. Totals of 103 patients and 122 healthy controls were included. All participants were stratified into four groups according to their age: 18–29 years, 30–39 years, 40–49 years, and 50–59 years. Clinical data, plasma Hcy levels, and cognitive function score were collected. Cognitive function was evaluated using the MATRICS Consensus Cognitive Battery of tests assessing speed of processing, verbal learning and memory, visual learning and memory, working memory, and attention/vigilance. Compared with the healthy group, Hcy levels increased significantly, and all the measured cognitive function score were significantly lower in all age groups of patients with schizophrenia (
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| doi_str_mv | 10.1038/s41598-021-99239-3 |
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p
< 0.001). Hcy levels were negatively associated with speed of processing (SoP), working memory (WM), and visual learning and memory (Vis Lrng) score in 18–29 years. Further multiple regression analysis showed that SoP were independently associated with Hcy levels in patients with schizophrenia aged 18–29 years (B = 0.74, t = 3.12, p = 0.008). Based on our results, patients with schizophrenia performed worse on cognitive assessments and Hcy levels were more closely related to cognition in young patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-99239-3</identifier><identifier>PMID: 34611243</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/477 ; 631/477/2811 ; 692/699 ; Adolescent ; Adult ; Age ; Age groups ; Biomarkers ; Case-Control Studies ; Cognitive ability ; Cognitive Dysfunction - blood ; Cognitive Dysfunction - diagnosis ; Female ; Homocysteine ; Homocysteine - blood ; Humanities and Social Sciences ; Humans ; Information processing ; Male ; Memory ; Mental disorders ; Middle Aged ; multidisciplinary ; Multidisciplinary Sciences ; Multiple regression analysis ; Patients ; Prognosis ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - diagnosis ; Schizophrenic Psychology ; Science ; Science & Technology ; Science & Technology - Other Topics ; Science (multidisciplinary) ; Short term memory ; Symptom Assessment ; Vigilance ; Visual discrimination learning ; Young Adult</subject><ispartof>Scientific reports, 2021-10, Vol.11 (1), p.19716-19716, Article 19716</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>6</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000704088100108</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c540t-989c9bb238769a911bd6b508afe537cf14ea3789b4ca4e7702e1d4998d670f563</citedby><cites>FETCH-LOGICAL-c540t-989c9bb238769a911bd6b508afe537cf14ea3789b4ca4e7702e1d4998d670f563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492650/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492650/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27928,27929,41124,42193,51580,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34611243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Sumiao</creatorcontrib><creatorcontrib>Huang, Yuanyuan</creatorcontrib><creatorcontrib>Feng, Yangdong</creatorcontrib><creatorcontrib>Li, Hehua</creatorcontrib><creatorcontrib>Wu, Kai</creatorcontrib><creatorcontrib>Yang, Mingzhe</creatorcontrib><creatorcontrib>Wu, Fengchun</creatorcontrib><creatorcontrib>Huang, Xingbing</creatorcontrib><title>Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>SCI REP-UK</addtitle><addtitle>Sci Rep</addtitle><description>It was still unclear how homocysteine (Hcy) levels and cognitive deficits change in patients with schizophrenia of various ages. The present article attempts to assess the relationship between Hcy levels and cognitive deficits in patients with schizophrenia across age groups, especially in young people. Totals of 103 patients and 122 healthy controls were included. All participants were stratified into four groups according to their age: 18–29 years, 30–39 years, 40–49 years, and 50–59 years. Clinical data, plasma Hcy levels, and cognitive function score were collected. Cognitive function was evaluated using the MATRICS Consensus Cognitive Battery of tests assessing speed of processing, verbal learning and memory, visual learning and memory, working memory, and attention/vigilance. Compared with the healthy group, Hcy levels increased significantly, and all the measured cognitive function score were significantly lower in all age groups of patients with schizophrenia (
p
< 0.001). Hcy levels were negatively associated with speed of processing (SoP), working memory (WM), and visual learning and memory (Vis Lrng) score in 18–29 years. Further multiple regression analysis showed that SoP were independently associated with Hcy levels in patients with schizophrenia aged 18–29 years (B = 0.74, t = 3.12, p = 0.008). Based on our results, patients with schizophrenia performed worse on cognitive assessments and Hcy levels were more closely related to cognition in young patients.</description><subject>631/477</subject><subject>631/477/2811</subject><subject>692/699</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age groups</subject><subject>Biomarkers</subject><subject>Case-Control Studies</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - blood</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Female</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Information processing</subject><subject>Male</subject><subject>Memory</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Multidisciplinary Sciences</subject><subject>Multiple regression analysis</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenic Psychology</subject><subject>Science</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Science (multidisciplinary)</subject><subject>Short term memory</subject><subject>Symptom Assessment</subject><subject>Vigilance</subject><subject>Visual discrimination learning</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhiMEolXpH-CALHFBQgF_JbYvSNUKaKVKXOBsOc4k8SprBzvpqhz55bibsrQcEL7YGj_zemb8FsVLgt8RzOT7xEmlZIkpKZWiTJXsSXFKMa9Kyih9-uB8UpyntMV5VVRxop4XJ4zXhFDOToufFykF68zsgkcNzHsAj6bRpJ1BQ9gFe5tmcB7QCDcwJmR8i2zovZvdDaAWOmfdnJDz6NJ4tBkymgBNWQ98ju_dPKBkB_cjTEME7wwyNoaUhXpAfQzLlF4UzzozJji_38-Kb58-ft1cltdfPl9tLq5LW3E8l0oqq5qGMilqZRQhTVs3FZamg4oJ2xEOhgmpGm4NByEwBdJypWRbC9xVNTsrrlbdNpitnqLbmXirg3H6EAix1ybOzo6gO0JqxTsmlLScyM5AfsRUtKG4tS1A1vqwak1Ls4PW5majGR-JPr7xbtB9uNGSK1pXOAu8uReI4fsCadY7lyyMo_EQlqRpJVRNJSEqo6__QrdhiT6P6kBRLAS7o-hKHcYboTsWQ7C-c4xeHaOzY_TBMZrlpFcP2zim_PZHBuQK7KEJXbL5Vy0csWwpgTmWkmBMsNy4-eCjTVj8nFPf_n9qptlKp0z4HuKfJv9R_y-pMe-f</recordid><startdate>20211005</startdate><enddate>20211005</enddate><creator>Zhou, Sumiao</creator><creator>Huang, Yuanyuan</creator><creator>Feng, Yangdong</creator><creator>Li, Hehua</creator><creator>Wu, Kai</creator><creator>Yang, Mingzhe</creator><creator>Wu, Fengchun</creator><creator>Huang, Xingbing</creator><general>Nature Publishing Group UK</general><general>NATURE PORTFOLIO</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20211005</creationdate><title>Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups</title><author>Zhou, Sumiao ; Huang, Yuanyuan ; Feng, Yangdong ; Li, Hehua ; Wu, Kai ; Yang, Mingzhe ; Wu, Fengchun ; Huang, Xingbing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-989c9bb238769a911bd6b508afe537cf14ea3789b4ca4e7702e1d4998d670f563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/477</topic><topic>631/477/2811</topic><topic>692/699</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age groups</topic><topic>Biomarkers</topic><topic>Case-Control Studies</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Sumiao</au><au>Huang, Yuanyuan</au><au>Feng, Yangdong</au><au>Li, Hehua</au><au>Wu, Kai</au><au>Yang, Mingzhe</au><au>Wu, Fengchun</au><au>Huang, Xingbing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><stitle>SCI REP-UK</stitle><addtitle>Sci Rep</addtitle><date>2021-10-05</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>19716</spage><epage>19716</epage><pages>19716-19716</pages><artnum>19716</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>It was still unclear how homocysteine (Hcy) levels and cognitive deficits change in patients with schizophrenia of various ages. The present article attempts to assess the relationship between Hcy levels and cognitive deficits in patients with schizophrenia across age groups, especially in young people. Totals of 103 patients and 122 healthy controls were included. All participants were stratified into four groups according to their age: 18–29 years, 30–39 years, 40–49 years, and 50–59 years. Clinical data, plasma Hcy levels, and cognitive function score were collected. Cognitive function was evaluated using the MATRICS Consensus Cognitive Battery of tests assessing speed of processing, verbal learning and memory, visual learning and memory, working memory, and attention/vigilance. Compared with the healthy group, Hcy levels increased significantly, and all the measured cognitive function score were significantly lower in all age groups of patients with schizophrenia (
p
< 0.001). Hcy levels were negatively associated with speed of processing (SoP), working memory (WM), and visual learning and memory (Vis Lrng) score in 18–29 years. Further multiple regression analysis showed that SoP were independently associated with Hcy levels in patients with schizophrenia aged 18–29 years (B = 0.74, t = 3.12, p = 0.008). Based on our results, patients with schizophrenia performed worse on cognitive assessments and Hcy levels were more closely related to cognition in young patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34611243</pmid><doi>10.1038/s41598-021-99239-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/477 631/477/2811 692/699 Adolescent Adult Age Age groups Biomarkers Case-Control Studies Cognitive ability Cognitive Dysfunction - blood Cognitive Dysfunction - diagnosis Female Homocysteine Homocysteine - blood Humanities and Social Sciences Humans Information processing Male Memory Mental disorders Middle Aged multidisciplinary Multidisciplinary Sciences Multiple regression analysis Patients Prognosis Schizophrenia Schizophrenia - blood Schizophrenia - diagnosis Schizophrenic Psychology Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Short term memory Symptom Assessment Vigilance Visual discrimination learning Young Adult |
| title | Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups |
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