Post-COVID-19 pulmonary fibrosis and its predictive factors: a prospective study
Background We aimed to prospectively assess the lung fibrotic-like changes, as well as to explore their predictive factors, in the patients who survived Coronavirus Disease 2019 (COVID-19) infection. In this prospective cross-sectional study, we recruited patients who had been treated for moderate o...
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| Veröffentlicht in: | Egyptian Journal of Radiology and Nuclear Medicine 2021-10, Vol.52 (1), p.248-7, Article 248 |
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| creator | Nabahati, Mehrdad Ebrahimpour, Soheil Khaleghnejad Tabari, Reza Mehraeen, Rahele |
| description | Background
We aimed to prospectively assess the lung fibrotic-like changes, as well as to explore their predictive factors, in the patients who survived Coronavirus Disease 2019 (COVID-19) infection. In this prospective cross-sectional study, we recruited patients who had been treated for moderate or severe COVID-19 pneumonia as inpatients and discharged from Rohani hospital in Babol, northern Iran, during March 2020. The clinical severity of COVID-19 pneumonia was classified as per the definition by World Health Organization. We also calculated the CT severity score (CSS) for all patients at admission. Within the 3 months of follow-up, the next chest CT scan was performed. As the secondary outcome, the patients with fibrotic abnormalities in their second CT scan were followed up in the next 3 months.
Results
Totally, 173 COVID-19 patients were finally included in the study, of whom 57 (32.9%) were male and others were female. The mean age was 53.62 ± 13.67 years old. At 3-month CT follow-up, evidence of pulmonary fibrosis was observed in 90 patients (52.0%). Consolidation (odds ratio [OR] = 2.84), severe disease (OR 2.40), and a higher CSS (OR 1.10) at admission were associated with increased risk of fibrotic abnormalities found at 3-month CT follow-up. Of 62 patients who underwent chest CT scan again at 6 months of follow-up, 41 patients (66.1%) showed no considerable changes in the fibrotic findings, while the rest of 21 patients (33.9%) showed relatively diminished lung fibrosis.
Conclusion
Post-COVID-19 lung fibrosis was observed in about half of the survivors. Also, patients with severe COVID-19 pneumonia were at a higher risk of pulmonary fibrosis. Moreover, consolidation, as well as a higher CSS, in the initial chest CT scan, was associated with increased risk of post-COVID-19 lung fibrosis. In addition, some patients experienced diminished fibrotic abnormalities in their chest CT on 6-month follow-up, while some others did not. |
| doi_str_mv | 10.1186/s43055-021-00632-9 |
| format | Article |
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We aimed to prospectively assess the lung fibrotic-like changes, as well as to explore their predictive factors, in the patients who survived Coronavirus Disease 2019 (COVID-19) infection. In this prospective cross-sectional study, we recruited patients who had been treated for moderate or severe COVID-19 pneumonia as inpatients and discharged from Rohani hospital in Babol, northern Iran, during March 2020. The clinical severity of COVID-19 pneumonia was classified as per the definition by World Health Organization. We also calculated the CT severity score (CSS) for all patients at admission. Within the 3 months of follow-up, the next chest CT scan was performed. As the secondary outcome, the patients with fibrotic abnormalities in their second CT scan were followed up in the next 3 months.
Results
Totally, 173 COVID-19 patients were finally included in the study, of whom 57 (32.9%) were male and others were female. The mean age was 53.62 ± 13.67 years old. At 3-month CT follow-up, evidence of pulmonary fibrosis was observed in 90 patients (52.0%). Consolidation (odds ratio [OR] = 2.84), severe disease (OR 2.40), and a higher CSS (OR 1.10) at admission were associated with increased risk of fibrotic abnormalities found at 3-month CT follow-up. Of 62 patients who underwent chest CT scan again at 6 months of follow-up, 41 patients (66.1%) showed no considerable changes in the fibrotic findings, while the rest of 21 patients (33.9%) showed relatively diminished lung fibrosis.
Conclusion
Post-COVID-19 lung fibrosis was observed in about half of the survivors. Also, patients with severe COVID-19 pneumonia were at a higher risk of pulmonary fibrosis. Moreover, consolidation, as well as a higher CSS, in the initial chest CT scan, was associated with increased risk of post-COVID-19 lung fibrosis. In addition, some patients experienced diminished fibrotic abnormalities in their chest CT on 6-month follow-up, while some others did not.</description><identifier>ISSN: 2090-4762</identifier><identifier>ISSN: 0378-603X</identifier><identifier>EISSN: 2090-4762</identifier><identifier>DOI: 10.1186/s43055-021-00632-9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Asthma ; Bacterial pneumonia ; Care and treatment ; Chronic obstructive pulmonary disease ; Comorbidity ; Computed tomography ; Confidence intervals ; Coronavirus Disease 2019 ; Coronaviruses ; COVID-19 ; CT imaging ; Diabetes ; Dyspnea ; Fever ; Health aspects ; Imaging ; Infections ; Laboratories ; Medical imaging ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Nuclear Medicine ; Oxygen saturation ; Pneumonia ; Pulmonary fibrosis ; Radiology ; Regression analysis ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2</subject><ispartof>Egyptian Journal of Radiology and Nuclear Medicine, 2021-10, Vol.52 (1), p.248-7, Article 248</ispartof><rights>The Author(s) 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-152a6be6eff127fb1169af7395c6ac098375cb5996962ed6f7bc4c8a54638ec13</citedby><cites>FETCH-LOGICAL-c551t-152a6be6eff127fb1169af7395c6ac098375cb5996962ed6f7bc4c8a54638ec13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,861,882,27905,27906</link.rule.ids></links><search><creatorcontrib>Nabahati, Mehrdad</creatorcontrib><creatorcontrib>Ebrahimpour, Soheil</creatorcontrib><creatorcontrib>Khaleghnejad Tabari, Reza</creatorcontrib><creatorcontrib>Mehraeen, Rahele</creatorcontrib><title>Post-COVID-19 pulmonary fibrosis and its predictive factors: a prospective study</title><title>Egyptian Journal of Radiology and Nuclear Medicine</title><addtitle>Egypt J Radiol Nucl Med</addtitle><description>Background
We aimed to prospectively assess the lung fibrotic-like changes, as well as to explore their predictive factors, in the patients who survived Coronavirus Disease 2019 (COVID-19) infection. In this prospective cross-sectional study, we recruited patients who had been treated for moderate or severe COVID-19 pneumonia as inpatients and discharged from Rohani hospital in Babol, northern Iran, during March 2020. The clinical severity of COVID-19 pneumonia was classified as per the definition by World Health Organization. We also calculated the CT severity score (CSS) for all patients at admission. Within the 3 months of follow-up, the next chest CT scan was performed. As the secondary outcome, the patients with fibrotic abnormalities in their second CT scan were followed up in the next 3 months.
Results
Totally, 173 COVID-19 patients were finally included in the study, of whom 57 (32.9%) were male and others were female. The mean age was 53.62 ± 13.67 years old. At 3-month CT follow-up, evidence of pulmonary fibrosis was observed in 90 patients (52.0%). Consolidation (odds ratio [OR] = 2.84), severe disease (OR 2.40), and a higher CSS (OR 1.10) at admission were associated with increased risk of fibrotic abnormalities found at 3-month CT follow-up. Of 62 patients who underwent chest CT scan again at 6 months of follow-up, 41 patients (66.1%) showed no considerable changes in the fibrotic findings, while the rest of 21 patients (33.9%) showed relatively diminished lung fibrosis.
Conclusion
Post-COVID-19 lung fibrosis was observed in about half of the survivors. Also, patients with severe COVID-19 pneumonia were at a higher risk of pulmonary fibrosis. Moreover, consolidation, as well as a higher CSS, in the initial chest CT scan, was associated with increased risk of post-COVID-19 lung fibrosis. In addition, some patients experienced diminished fibrotic abnormalities in their chest CT on 6-month follow-up, while some others did not.</description><subject>Asthma</subject><subject>Bacterial pneumonia</subject><subject>Care and treatment</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Comorbidity</subject><subject>Computed tomography</subject><subject>Confidence intervals</subject><subject>Coronavirus Disease 2019</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>CT imaging</subject><subject>Diabetes</subject><subject>Dyspnea</subject><subject>Fever</subject><subject>Health aspects</subject><subject>Imaging</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Nuclear Medicine</subject><subject>Oxygen saturation</subject><subject>Pneumonia</subject><subject>Pulmonary fibrosis</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9Uktr3DAYFKWFhm3-QE-Gnp3qLauHQtg-shBIDm2vQpY-bbWsLVeyA_n3VeOQdKFUOkiMvhlGzCD0luALQjr5vnCGhWgxJS3GktFWv0BnFGvcciXpy7_ur9F5KQdcF8eYSH6Gbm9TmdvtzY_dp5boZlqOQxptvm9C7HMqsTR29E2cSzNl8NHN8Q6aYN2ccvnQ2IqmMsEKl3nx92_Qq2CPBc4fzw36_uXzt-1Ve33zdbe9vG6dEGRuiaBW9iAhBEJV6AmR2gbFtHDSOqw7poTrhdZSSwpeBtU77joruGQdOMI2aLfq-mQPZspxqK5NstE8ACnvjc1zdEcwgTJGOUgBmPBe-M4qy7VSgoLEnkHV-rhqTUs_gHcwztkeT0RPX8b40-zTnem4rgmIKvDuUSCnXwuU2RzSksf6f0NV13HGOKHPU3tbXcUxpCrmhlicuZQdplSJGt8GXfxjqm4PQ3RphBArfkKgK8HVLEqG8GScYPOnIGYtiKkFMQ8FMbqS2EoqdXjcQ352_B_Wb952u_w</recordid><startdate>20211005</startdate><enddate>20211005</enddate><creator>Nabahati, Mehrdad</creator><creator>Ebrahimpour, Soheil</creator><creator>Khaleghnejad Tabari, Reza</creator><creator>Mehraeen, Rahele</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20211005</creationdate><title>Post-COVID-19 pulmonary fibrosis and its predictive factors: a prospective study</title><author>Nabahati, Mehrdad ; Ebrahimpour, Soheil ; Khaleghnejad Tabari, Reza ; Mehraeen, Rahele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-152a6be6eff127fb1169af7395c6ac098375cb5996962ed6f7bc4c8a54638ec13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Asthma</topic><topic>Bacterial pneumonia</topic><topic>Care and treatment</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Comorbidity</topic><topic>Computed tomography</topic><topic>Confidence intervals</topic><topic>Coronavirus Disease 2019</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>CT imaging</topic><topic>Diabetes</topic><topic>Dyspnea</topic><topic>Fever</topic><topic>Health aspects</topic><topic>Imaging</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Nuclear Medicine</topic><topic>Oxygen saturation</topic><topic>Pneumonia</topic><topic>Pulmonary fibrosis</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nabahati, Mehrdad</creatorcontrib><creatorcontrib>Ebrahimpour, Soheil</creatorcontrib><creatorcontrib>Khaleghnejad Tabari, Reza</creatorcontrib><creatorcontrib>Mehraeen, Rahele</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nabahati, Mehrdad</au><au>Ebrahimpour, Soheil</au><au>Khaleghnejad Tabari, Reza</au><au>Mehraeen, Rahele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-COVID-19 pulmonary fibrosis and its predictive factors: a prospective study</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2021-10-05</date><risdate>2021</risdate><volume>52</volume><issue>1</issue><spage>248</spage><epage>7</epage><pages>248-7</pages><artnum>248</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background
We aimed to prospectively assess the lung fibrotic-like changes, as well as to explore their predictive factors, in the patients who survived Coronavirus Disease 2019 (COVID-19) infection. In this prospective cross-sectional study, we recruited patients who had been treated for moderate or severe COVID-19 pneumonia as inpatients and discharged from Rohani hospital in Babol, northern Iran, during March 2020. The clinical severity of COVID-19 pneumonia was classified as per the definition by World Health Organization. We also calculated the CT severity score (CSS) for all patients at admission. Within the 3 months of follow-up, the next chest CT scan was performed. As the secondary outcome, the patients with fibrotic abnormalities in their second CT scan were followed up in the next 3 months.
Results
Totally, 173 COVID-19 patients were finally included in the study, of whom 57 (32.9%) were male and others were female. The mean age was 53.62 ± 13.67 years old. At 3-month CT follow-up, evidence of pulmonary fibrosis was observed in 90 patients (52.0%). Consolidation (odds ratio [OR] = 2.84), severe disease (OR 2.40), and a higher CSS (OR 1.10) at admission were associated with increased risk of fibrotic abnormalities found at 3-month CT follow-up. Of 62 patients who underwent chest CT scan again at 6 months of follow-up, 41 patients (66.1%) showed no considerable changes in the fibrotic findings, while the rest of 21 patients (33.9%) showed relatively diminished lung fibrosis.
Conclusion
Post-COVID-19 lung fibrosis was observed in about half of the survivors. Also, patients with severe COVID-19 pneumonia were at a higher risk of pulmonary fibrosis. Moreover, consolidation, as well as a higher CSS, in the initial chest CT scan, was associated with increased risk of post-COVID-19 lung fibrosis. In addition, some patients experienced diminished fibrotic abnormalities in their chest CT on 6-month follow-up, while some others did not.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43055-021-00632-9</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Asthma Bacterial pneumonia Care and treatment Chronic obstructive pulmonary disease Comorbidity Computed tomography Confidence intervals Coronavirus Disease 2019 Coronaviruses COVID-19 CT imaging Diabetes Dyspnea Fever Health aspects Imaging Infections Laboratories Medical imaging Medical research Medicine Medicine & Public Health Medicine, Experimental Nuclear Medicine Oxygen saturation Pneumonia Pulmonary fibrosis Radiology Regression analysis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 |
| title | Post-COVID-19 pulmonary fibrosis and its predictive factors: a prospective study |
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