Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients
Purpose Laparoscopic sleeve gastrectomy (LSG) is an effective weight loss procedure, but detrimental effects on bone health have been described. We aimed to assess the dynamics of regional and total bone mineral density (BMD) in a cohort of patients undergoing LSG and to capture gender differences i...
Gespeichert in:
| Veröffentlicht in: | Obesity surgery 2021-11, Vol.31 (11), p.4885-4892 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4892 |
|---|---|
| container_issue | 11 |
| container_start_page | 4885 |
| container_title | Obesity surgery |
| container_volume | 31 |
| creator | Malinici, Elisabeta Sirbu, Anca Popa, Miruna Andrei, Marian Ioacara, Sorin Copaescu, Catalin Fica, Simona |
| description | Purpose
Laparoscopic sleeve gastrectomy (LSG) is an effective weight loss procedure, but detrimental effects on bone health have been described. We aimed to assess the dynamics of regional and total bone mineral density (BMD) in a cohort of patients undergoing LSG and to capture gender differences in terms of evolution.
Materials and Methods
We conducted a retrospective study on 241 patients who underwent LSG to determine the regional and total BMD changes at 6 and 12 months after the intervention.
Results
One hundred ten males and 140 females (97 pre-, 43 postmenopausal) were included. Mean baseline body mass index (BMI) was 44.16 ± 6.11 kg/m
2
in males and 41.60 ± 5.54 kg/m
2
in females, reaching 28.62 ± 4.26 kg/m
2
and 27.39 ± 4.2 kg/m
2
, respectively, at 12 months. BMD showed a continuous decline, with significant loss from 6 months postoperatively. There was a positive correlation between BMD and BMI decline at 12 months (
r
= 0.134,
p |
| doi_str_mv | 10.1007/s11695-021-05661-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8490210</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2566039634</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-aac1da30484b2bbc7eea1daa56536931f1b279a08b77c3cb86aa08693eaaae2c3</originalsourceid><addsrcrecordid>eNp9kctuUzEQhi0EoqHwAiyQJTbdHPDt3DZIJb2AFARSy4KVNceZNK5O7IPtUyU7HqJP2CfBaXoBFqwse775f8_8hLzm7B1nrH4fOa_asmCCF6ysKl6sn5AJr1lTMCWap2TC2ooVTSvkHnkR4yXLZCXEc7InlVItE82ErD96h_SLdRigp0fook0beh7QzSM9GoN1FzQtkZ7YEBP9gRDo4SJhoDMYIPho_GANPesRr5CeQkwBTfKrzc2va6BTv_Qh0bM0zjfUOyoUp98gWXQpviTPFtBHfHV37pPvJ8fn00_F7Ovp5-nhrDClYqkAMHwOkqlGdaLrTI0I-QHKqpRVK_mCd6JugTVdXRtpuqaCfMkVBAAURu6TDzvdYexWODfZO0-qh2BXEDbag9V_V5xd6gt_pZvthjjLAgd3AsH_HDEmvbLRYN-DQz9GLfLqmWwrqTL69h_00o_B5fEyVTctL-tbSuwok_cXAy4ePsOZ3gard8HqbK9vg9Xr3PTmzzEeWu6TzIDcAXHYhobh0fs_sr8BHhCxuA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2578915734</pqid></control><display><type>article</type><title>Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Malinici, Elisabeta ; Sirbu, Anca ; Popa, Miruna ; Andrei, Marian ; Ioacara, Sorin ; Copaescu, Catalin ; Fica, Simona</creator><creatorcontrib>Malinici, Elisabeta ; Sirbu, Anca ; Popa, Miruna ; Andrei, Marian ; Ioacara, Sorin ; Copaescu, Catalin ; Fica, Simona</creatorcontrib><description>Purpose
Laparoscopic sleeve gastrectomy (LSG) is an effective weight loss procedure, but detrimental effects on bone health have been described. We aimed to assess the dynamics of regional and total bone mineral density (BMD) in a cohort of patients undergoing LSG and to capture gender differences in terms of evolution.
Materials and Methods
We conducted a retrospective study on 241 patients who underwent LSG to determine the regional and total BMD changes at 6 and 12 months after the intervention.
Results
One hundred ten males and 140 females (97 pre-, 43 postmenopausal) were included. Mean baseline body mass index (BMI) was 44.16 ± 6.11 kg/m
2
in males and 41.60 ± 5.54 kg/m
2
in females, reaching 28.62 ± 4.26 kg/m
2
and 27.39 ± 4.2 kg/m
2
, respectively, at 12 months. BMD showed a continuous decline, with significant loss from 6 months postoperatively. There was a positive correlation between BMD and BMI decline at 12 months (
r
= 0.134,
p
< 0.05). Total BMD loss at 12 months was significantly greater in males than premenopausal females, independent of BMI variation and age. During the first 6 months, men lost significantly more bone mass than premenopausal and postmenopausal women (BMD variation was 2.62%, 0.27%, 1.58%, respectively). The second period (6–12 months) was similar in all three groups, revealing a further steady (~ 1.4%) BMD decline.
Conclusions
Our results are consistent with previous findings that LSG negatively impacts BMD, stressing the importance of bone health-oriented measures in postoperative care. Moreover, the impact that seems more significant in males warrants future exploration, as it might change clinical practice.
Graphical abstract</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-021-05661-x</identifier><identifier>PMID: 34449028</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Body mass index ; Bone Density ; Cohort analysis ; Cohort Studies ; Female ; Gastrectomy ; Gastrointestinal surgery ; Humans ; Laparoscopy ; Male ; Medicine ; Medicine & Public Health ; Obesity, Morbid - surgery ; Original Contributions ; Retrospective Studies ; Surgery</subject><ispartof>Obesity surgery, 2021-11, Vol.31 (11), p.4885-4892</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-aac1da30484b2bbc7eea1daa56536931f1b279a08b77c3cb86aa08693eaaae2c3</citedby><cites>FETCH-LOGICAL-c540t-aac1da30484b2bbc7eea1daa56536931f1b279a08b77c3cb86aa08693eaaae2c3</cites><orcidid>0000-0003-3659-4544</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-021-05661-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-021-05661-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34449028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malinici, Elisabeta</creatorcontrib><creatorcontrib>Sirbu, Anca</creatorcontrib><creatorcontrib>Popa, Miruna</creatorcontrib><creatorcontrib>Andrei, Marian</creatorcontrib><creatorcontrib>Ioacara, Sorin</creatorcontrib><creatorcontrib>Copaescu, Catalin</creatorcontrib><creatorcontrib>Fica, Simona</creatorcontrib><title>Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Purpose
Laparoscopic sleeve gastrectomy (LSG) is an effective weight loss procedure, but detrimental effects on bone health have been described. We aimed to assess the dynamics of regional and total bone mineral density (BMD) in a cohort of patients undergoing LSG and to capture gender differences in terms of evolution.
Materials and Methods
We conducted a retrospective study on 241 patients who underwent LSG to determine the regional and total BMD changes at 6 and 12 months after the intervention.
Results
One hundred ten males and 140 females (97 pre-, 43 postmenopausal) were included. Mean baseline body mass index (BMI) was 44.16 ± 6.11 kg/m
2
in males and 41.60 ± 5.54 kg/m
2
in females, reaching 28.62 ± 4.26 kg/m
2
and 27.39 ± 4.2 kg/m
2
, respectively, at 12 months. BMD showed a continuous decline, with significant loss from 6 months postoperatively. There was a positive correlation between BMD and BMI decline at 12 months (
r
= 0.134,
p
< 0.05). Total BMD loss at 12 months was significantly greater in males than premenopausal females, independent of BMI variation and age. During the first 6 months, men lost significantly more bone mass than premenopausal and postmenopausal women (BMD variation was 2.62%, 0.27%, 1.58%, respectively). The second period (6–12 months) was similar in all three groups, revealing a further steady (~ 1.4%) BMD decline.
Conclusions
Our results are consistent with previous findings that LSG negatively impacts BMD, stressing the importance of bone health-oriented measures in postoperative care. Moreover, the impact that seems more significant in males warrants future exploration, as it might change clinical practice.
Graphical abstract</description><subject>Body mass index</subject><subject>Bone Density</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctuUzEQhi0EoqHwAiyQJTbdHPDt3DZIJb2AFARSy4KVNceZNK5O7IPtUyU7HqJP2CfBaXoBFqwse775f8_8hLzm7B1nrH4fOa_asmCCF6ysKl6sn5AJr1lTMCWap2TC2ooVTSvkHnkR4yXLZCXEc7InlVItE82ErD96h_SLdRigp0fook0beh7QzSM9GoN1FzQtkZ7YEBP9gRDo4SJhoDMYIPho_GANPesRr5CeQkwBTfKrzc2va6BTv_Qh0bM0zjfUOyoUp98gWXQpviTPFtBHfHV37pPvJ8fn00_F7Ovp5-nhrDClYqkAMHwOkqlGdaLrTI0I-QHKqpRVK_mCd6JugTVdXRtpuqaCfMkVBAAURu6TDzvdYexWODfZO0-qh2BXEDbag9V_V5xd6gt_pZvthjjLAgd3AsH_HDEmvbLRYN-DQz9GLfLqmWwrqTL69h_00o_B5fEyVTctL-tbSuwok_cXAy4ePsOZ3gard8HqbK9vg9Xr3PTmzzEeWu6TzIDcAXHYhobh0fs_sr8BHhCxuA</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Malinici, Elisabeta</creator><creator>Sirbu, Anca</creator><creator>Popa, Miruna</creator><creator>Andrei, Marian</creator><creator>Ioacara, Sorin</creator><creator>Copaescu, Catalin</creator><creator>Fica, Simona</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3659-4544</orcidid></search><sort><creationdate>20211101</creationdate><title>Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients</title><author>Malinici, Elisabeta ; Sirbu, Anca ; Popa, Miruna ; Andrei, Marian ; Ioacara, Sorin ; Copaescu, Catalin ; Fica, Simona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-aac1da30484b2bbc7eea1daa56536931f1b279a08b77c3cb86aa08693eaaae2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Body mass index</topic><topic>Bone Density</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malinici, Elisabeta</creatorcontrib><creatorcontrib>Sirbu, Anca</creatorcontrib><creatorcontrib>Popa, Miruna</creatorcontrib><creatorcontrib>Andrei, Marian</creatorcontrib><creatorcontrib>Ioacara, Sorin</creatorcontrib><creatorcontrib>Copaescu, Catalin</creatorcontrib><creatorcontrib>Fica, Simona</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malinici, Elisabeta</au><au>Sirbu, Anca</au><au>Popa, Miruna</au><au>Andrei, Marian</au><au>Ioacara, Sorin</au><au>Copaescu, Catalin</au><au>Fica, Simona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>31</volume><issue>11</issue><spage>4885</spage><epage>4892</epage><pages>4885-4892</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Purpose
Laparoscopic sleeve gastrectomy (LSG) is an effective weight loss procedure, but detrimental effects on bone health have been described. We aimed to assess the dynamics of regional and total bone mineral density (BMD) in a cohort of patients undergoing LSG and to capture gender differences in terms of evolution.
Materials and Methods
We conducted a retrospective study on 241 patients who underwent LSG to determine the regional and total BMD changes at 6 and 12 months after the intervention.
Results
One hundred ten males and 140 females (97 pre-, 43 postmenopausal) were included. Mean baseline body mass index (BMI) was 44.16 ± 6.11 kg/m
2
in males and 41.60 ± 5.54 kg/m
2
in females, reaching 28.62 ± 4.26 kg/m
2
and 27.39 ± 4.2 kg/m
2
, respectively, at 12 months. BMD showed a continuous decline, with significant loss from 6 months postoperatively. There was a positive correlation between BMD and BMI decline at 12 months (
r
= 0.134,
p
< 0.05). Total BMD loss at 12 months was significantly greater in males than premenopausal females, independent of BMI variation and age. During the first 6 months, men lost significantly more bone mass than premenopausal and postmenopausal women (BMD variation was 2.62%, 0.27%, 1.58%, respectively). The second period (6–12 months) was similar in all three groups, revealing a further steady (~ 1.4%) BMD decline.
Conclusions
Our results are consistent with previous findings that LSG negatively impacts BMD, stressing the importance of bone health-oriented measures in postoperative care. Moreover, the impact that seems more significant in males warrants future exploration, as it might change clinical practice.
Graphical abstract</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34449028</pmid><doi>10.1007/s11695-021-05661-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3659-4544</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-8923 |
| ispartof | Obesity surgery, 2021-11, Vol.31 (11), p.4885-4892 |
| issn | 0960-8923 1708-0428 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8490210 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Body mass index Bone Density Cohort analysis Cohort Studies Female Gastrectomy Gastrointestinal surgery Humans Laparoscopy Male Medicine Medicine & Public Health Obesity, Morbid - surgery Original Contributions Retrospective Studies Surgery |
| title | Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T03%3A26%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bone%20Mineral%20Density%20Trends%20During%20the%20First%20Year%20After%20Laparoscopic%20Sleeve%20Gastrectomy%E2%80%94a%20Cohort%20Study%20on%20241%20Patients&rft.jtitle=Obesity%20surgery&rft.au=Malinici,%20Elisabeta&rft.date=2021-11-01&rft.volume=31&rft.issue=11&rft.spage=4885&rft.epage=4892&rft.pages=4885-4892&rft.issn=0960-8923&rft.eissn=1708-0428&rft_id=info:doi/10.1007/s11695-021-05661-x&rft_dat=%3Cproquest_pubme%3E2566039634%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2578915734&rft_id=info:pmid/34449028&rfr_iscdi=true |