Layilin Anchors Regulatory T Cells in Skin

Regulatory T cells (Tregs) reside in nonlymphoid tissues where they carry out unique functions. The molecular mechanisms responsible for Treg accumulation and maintenance in these tissues are relatively unknown. Using an unbiased discovery approach, we identified LAYN (layilin), a C-type lectin-like...

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Veröffentlicht in:	The Journal of immunology (1950) 2021-10, Vol.207 (7), p.1763-1775
Hauptverfasser:	Mehta, Pooja, Gouirand, Victoire, Boda, Devi P., Zhang, Jingxian, Gearty, Sofia, Zirak, Bahar, Lowe, Margaret M., Clancy, Sean, Boothby, Ian, Mahuron, Kelly M., Fries, Adam, Krummel, Matthew F., Mankoo, Parminder, Chang, Hsin-Wen, Liu, Jared, Moreau, Joshua M., Scharschmidt, Tiffany C., Daud, Adil, Kim, Esther, Neuhaus, Isaac M., Harris, Hobart W., Liao, Wilson, Rosenblum, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Movement Cells, Cultured Humans Immune Tolerance Immunology Life Sciences & Biomedicine Lymphocyte Activation Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Models, Immunological Organ Specificity Receptors, Lymphocyte Homing - genetics Receptors, Lymphocyte Homing - metabolism Science & Technology Skin - immunology T-Lymphocytes, Regulatory - immunology Transforming Growth Factor beta - metabolism
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