Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2

The Sorbin and SH3 domain-containing protein 2 (Sorbs2) is an important component of cardiomyocyte sarcomere. It has been recently reported that loss of Sorbs2 is causally associated with arrhythmogenic cardiomyopathy in human. However, the ionic mechanisms leading to cardiac arrhythmogenesis by Sor...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2021-12, Vol.1867 (12), p.166247-166247, Article 166247
Hauptverfasser:	Qian, Ling-Ling, Sun, Xiaojing, Yang, Jingchun, Wang, Xiao-Li, Ackerman, Michael J., Wang, Ru-Xing, Xu, Xiaolei, Lee, Hon-Chi, Lu, Tong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Animals Arrhythmia Arrhythmias, Cardiac - diagnostic imaging Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - pathology Atrial Remodeling - genetics Calcium Channels, L-Type - genetics Disease Models, Animal Electrical remodeling Electrocardiography Gene Expression Regulation - genetics Humans Ion channelopathy Ion Channels - genetics Mice Mice, Knockout Myocardium Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Patch-Clamp Techniques Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Voltage-Gated - genetics RNA-Binding Proteins - genetics Sarcomeres - genetics Sarcomeres - metabolism Sorbs2 Voltage-Gated Sodium Channels - genetics
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