TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Somatic variants in and are founding mutations in hematological malignancies that affect the epigenetic regulation of DNA methylation. Mutations in both genes often co-occur with activating mutations in genes encoding oncogenic tyrosine kinases such as , and , or with mutations affecting related sig...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-10, Vol.81 (19), p.5089-5101
Hauptverfasser:	Maifrede, Silvia, Le, Bac Viet, Nieborowska-Skorska, Margaret, Golovine, Konstantin, Sullivan-Reed, Katherine, Dunuwille, Wangisa M B, Nacson, Joseph, Hulse, Michael, Keith, Kelsey, Madzo, Jozef, Caruso, Lisa Beatrice, Gazze, Zachary, Lian, Zhaorui, Padella, Antonella, Chitrala, Kumaraswamy N, Bartholdy, Boris A, Matlawska-Wasowska, Ksenia, Di Marcantonio, Daniela, Simonetti, Giorgia, Greiner, Georg, Sykes, Stephen M, Valent, Peter, Paietta, Elisabeth M, Tallman, Martin S, Fernandez, Hugo F, Litzow, Mark R, Minden, Mark D, Huang, Jian, Martinelli, Giovanni, Vassiliou, George S, Tempera, Italo, Piwocka, Katarzyna, Johnson, Neil, Challen, Grant A, Skorski, Tomasz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor CRISPR-Cas Systems Dioxygenases - genetics Disease Models, Animal DNA Methyltransferase 3A - genetics DNA Repair DNA-Binding Proteins - genetics Dose-Response Relationship, Drug Drug Resistance, Neoplasm - genetics Gene Knockdown Techniques Genotype Humans Leukemia Mice Mice, Transgenic Models, Biological Mutation Neoplastic Stem Cells Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Xenograft Model Antitumor Assays
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