Copper-Catalyzed Cross-Coupling of Benzylic C–H Bonds and Azoles with Controlled N‑Site Selectivity

Azoles are important motifs in medicinal chemistry, and elaboration of their structures via direct N–H/C–H coupling could have broad utility in drug discovery. The ambident reactivity of many azoles, however, presents significant selectivity challenges. Here, we report a copper-catalyzed method that...

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Veröffentlicht in:	Journal of the American Chemical Society 2021-09, Vol.143 (36), p.14438-14444
Hauptverfasser:	Chen, Si-Jie, Golden, Dung L, Krska, Shane W, Stahl, Shannon S
Format:	Artikel
Sprache:	eng
Schlagworte:	Azoles - chemical synthesis Benzyl Compounds - chemistry Catalysis Copper - chemistry Indans - chemistry Molecular Structure Oxidants - chemistry Oxidation-Reduction Sulfonamides - chemistry
Online-Zugang:	Volltext
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