Sequential adaptation of perfusion and transport conditions significantly improves vascular construct recellularization and biomechanics

Recellularization of ex vivo‐derived scaffolds remains a significant hurdle primarily due to the scaffolds subcellular pore size that restricts initial cell seeding to the scaffolds periphery and inhibits migration over time. With the aim to improve cell migration, repopulation, and graft mechanics,...

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Veröffentlicht in:	Journal of tissue engineering and regenerative medicine 2020-03, Vol.14 (3), p.510-520
Hauptverfasser:	Van de Walle, Aurore B., Moore, Marc C., McFetridge, Peter S.
Format:	Artikel
Sprache:	eng
Schlagworte:	biomaterial Biomechanics Blood pressure Blood vessels Cell adhesion & migration Cell culture Cell migration Cell size Engineering Sciences ex vivo‐derived scaffold Glycosaminoglycans Mechanical properties Mechanics Modulus of elasticity Muscles Nutrient flow Nutrients Perfusion Pore size Porosity recellularization Regenerative medicine Repopulation Scaffolds small diameter vascular graft Smooth muscle Tissue engineering vascular tissue engineering vascular wall Veins
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