The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study
Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals. We collected viral sequences and epidemiological data of patients with community and h...
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| Veröffentlicht in: | The Journal of infection 2021-12, Vol.83 (6), p.693-700 |
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| creator | Boshier, Florencia A.T. Venturini, Cristina Stirrup, Oliver Guerra-Assunção, José Afonso Alcolea-Medina, Adela Becket, Angela H. Byott, Matthew Charalampous, Themoula Filipe, Ana da Silva Frampton, Dan Glaysher, Sharon Khan, Tabassum Kulasegara-Shylini, Raghavendran Kele, Beatrix Monahan, Irene M. Mollett, Guy Parker, Matthew Pelosi, Emanuela Randell, Paul Roy, Sunando Taylor, Joshua F. Weller, Sophie J. Wilson-Davies, Eleri Wade, Phillip Williams, Rachel Copas, Andrew J. Cutino-Moguel, Teresa Freemantle, Nick Hayward, Andrew C. Holmes, Alison Hughes, Joseph Mahungu, Tabitha W. Nebbia, Gaia Nastouli, Eleni Partridge, David G. Pope, Cassie F. Price, James R. Robson, Samuel C. Saeed, Kordo Shin, Gee Yen de Silva, Thushan I. Snell, Luke B. Thomson, Emma C. Witney, Adam A. Breuer, Judith |
| description | Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals.
We collected viral sequences and epidemiological data of patients with community and healthcare associated SARS-CoV-2 infections, sampled from 16th November 2020 to 10th January 2021, from nine hospitals participating in the COG-UK HOCI study. Outbreaks were identified using ward information, lineage and pairwise genetic differences between viral sequences.
Mixed effects logistic regression analysis of 4184 sequences showed healthcare-acquired infections were no more likely to be identified as the Alpha variant than community acquired infections. Nosocomial outbreaks were investigated based on overlapping ward stay and SARS-CoV-2 genome sequence similarity. There was no significant difference in the number of patients involved in outbreaks caused by the Alpha variant compared to outbreaks caused by other lineages.
We find no evidence to support it causing more nosocomial transmission than previous lineages. This suggests that the stringent infection prevention measures already in place in UK hospitals contained the spread of the Alpha variant as effectively as other less transmissible lineages, providing reassurance of their efficacy against emerging variants of concern. |
| doi_str_mv | 10.1016/j.jinf.2021.09.022 |
| format | Article |
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We collected viral sequences and epidemiological data of patients with community and healthcare associated SARS-CoV-2 infections, sampled from 16th November 2020 to 10th January 2021, from nine hospitals participating in the COG-UK HOCI study. Outbreaks were identified using ward information, lineage and pairwise genetic differences between viral sequences.
Mixed effects logistic regression analysis of 4184 sequences showed healthcare-acquired infections were no more likely to be identified as the Alpha variant than community acquired infections. Nosocomial outbreaks were investigated based on overlapping ward stay and SARS-CoV-2 genome sequence similarity. There was no significant difference in the number of patients involved in outbreaks caused by the Alpha variant compared to outbreaks caused by other lineages.
We find no evidence to support it causing more nosocomial transmission than previous lineages. This suggests that the stringent infection prevention measures already in place in UK hospitals contained the spread of the Alpha variant as effectively as other less transmissible lineages, providing reassurance of their efficacy against emerging variants of concern.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/j.jinf.2021.09.022</identifier><identifier>PMID: 34610391</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alpha variant ; COVID-19 ; Cross Infection - epidemiology ; Hospitals ; Humans ; Lineage B.1.1.7 ; Nosocomial outbreaks ; SARS-CoV-2 ; Transmissibility ; United Kingdom - epidemiology ; Variants of concern</subject><ispartof>The Journal of infection, 2021-12, Vol.83 (6), p.693-700</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Ltd.</rights><rights>2021 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-cccaf1f2c12cb38f5063319dc85ecc2079085c0abe486b7dd4b5e528bebb1f783</citedby><cites>FETCH-LOGICAL-c504t-cccaf1f2c12cb38f5063319dc85ecc2079085c0abe486b7dd4b5e528bebb1f783</cites><orcidid>0000-0003-4948-1004 ; 0000-0002-4769-7912 ; 0000-0002-8705-3281 ; 0000-0002-8914-5868 ; 0000-0002-4050-0064 ; 0000-0003-4303-5716 ; 0000-0003-2556-2563 ; 0000-0001-8968-5963 ; 0000-0003-2541-8545 ; 0000-0002-6263-9497 ; 0000-0002-6865-1948 ; 0000-0002-3145-0376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinf.2021.09.022$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34610391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boshier, Florencia A.T.</creatorcontrib><creatorcontrib>Venturini, Cristina</creatorcontrib><creatorcontrib>Stirrup, Oliver</creatorcontrib><creatorcontrib>Guerra-Assunção, José Afonso</creatorcontrib><creatorcontrib>Alcolea-Medina, Adela</creatorcontrib><creatorcontrib>Becket, Angela H.</creatorcontrib><creatorcontrib>Byott, Matthew</creatorcontrib><creatorcontrib>Charalampous, Themoula</creatorcontrib><creatorcontrib>Filipe, Ana da Silva</creatorcontrib><creatorcontrib>Frampton, Dan</creatorcontrib><creatorcontrib>Glaysher, Sharon</creatorcontrib><creatorcontrib>Khan, Tabassum</creatorcontrib><creatorcontrib>Kulasegara-Shylini, Raghavendran</creatorcontrib><creatorcontrib>Kele, Beatrix</creatorcontrib><creatorcontrib>Monahan, Irene M.</creatorcontrib><creatorcontrib>Mollett, Guy</creatorcontrib><creatorcontrib>Parker, Matthew</creatorcontrib><creatorcontrib>Pelosi, Emanuela</creatorcontrib><creatorcontrib>Randell, Paul</creatorcontrib><creatorcontrib>Roy, Sunando</creatorcontrib><creatorcontrib>Taylor, Joshua F.</creatorcontrib><creatorcontrib>Weller, Sophie J.</creatorcontrib><creatorcontrib>Wilson-Davies, Eleri</creatorcontrib><creatorcontrib>Wade, Phillip</creatorcontrib><creatorcontrib>Williams, Rachel</creatorcontrib><creatorcontrib>Copas, Andrew J.</creatorcontrib><creatorcontrib>Cutino-Moguel, Teresa</creatorcontrib><creatorcontrib>Freemantle, Nick</creatorcontrib><creatorcontrib>Hayward, Andrew C.</creatorcontrib><creatorcontrib>Holmes, Alison</creatorcontrib><creatorcontrib>Hughes, Joseph</creatorcontrib><creatorcontrib>Mahungu, Tabitha W.</creatorcontrib><creatorcontrib>Nebbia, Gaia</creatorcontrib><creatorcontrib>Nastouli, Eleni</creatorcontrib><creatorcontrib>Partridge, David G.</creatorcontrib><creatorcontrib>Pope, Cassie F.</creatorcontrib><creatorcontrib>Price, James R.</creatorcontrib><creatorcontrib>Robson, Samuel C.</creatorcontrib><creatorcontrib>Saeed, Kordo</creatorcontrib><creatorcontrib>Shin, Gee Yen</creatorcontrib><creatorcontrib>de Silva, Thushan I.</creatorcontrib><creatorcontrib>Snell, Luke B.</creatorcontrib><creatorcontrib>Thomson, Emma C.</creatorcontrib><creatorcontrib>Witney, Adam A.</creatorcontrib><creatorcontrib>Breuer, Judith</creatorcontrib><creatorcontrib>COG-UK HOCI Variant Substudy consortium, The COVID-19 Genomics UK (COG-UK) consortium</creatorcontrib><title>The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals.
We collected viral sequences and epidemiological data of patients with community and healthcare associated SARS-CoV-2 infections, sampled from 16th November 2020 to 10th January 2021, from nine hospitals participating in the COG-UK HOCI study. Outbreaks were identified using ward information, lineage and pairwise genetic differences between viral sequences.
Mixed effects logistic regression analysis of 4184 sequences showed healthcare-acquired infections were no more likely to be identified as the Alpha variant than community acquired infections. Nosocomial outbreaks were investigated based on overlapping ward stay and SARS-CoV-2 genome sequence similarity. There was no significant difference in the number of patients involved in outbreaks caused by the Alpha variant compared to outbreaks caused by other lineages.
We find no evidence to support it causing more nosocomial transmission than previous lineages. This suggests that the stringent infection prevention measures already in place in UK hospitals contained the spread of the Alpha variant as effectively as other less transmissible lineages, providing reassurance of their efficacy against emerging variants of concern.</description><subject>Alpha variant</subject><subject>COVID-19</subject><subject>Cross Infection - epidemiology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lineage B.1.1.7</subject><subject>Nosocomial outbreaks</subject><subject>SARS-CoV-2</subject><subject>Transmissibility</subject><subject>United Kingdom - epidemiology</subject><subject>Variants of concern</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAUtBCILoU_wAH5yCXBH3FiSwhptSofaqVK_eBqOc4L8SqJF9vZ0n-Pl20ruHB61nsz49EMQm8pKSmh9YdtuXVzXzLCaElUSRh7hlZUcFawpmLP0SqDeFFVgp-gVzFuCSGKq_olOuFVTQlXdIXSzQB4Pe4Gg_cmODMnfGcinn3CJkZvnUnQ4TuXBgy_LMTDKa_95MyIr9dX18XGfy8YzkbAJufn_MIGT8uYXGFhTgHw7TkefNy5lCkxLd39a_SiN2OENw_zFN1-PrvZfC0uLr9826wvCitIlQprrelpzyxltuWyF6TmnKrOSgHWMtIoIoUlpoVK1m3TdVUrQDDZQtvSvpH8FH066u6WdoLujx0z6l1wkwn32hun_73MbtA__F7LSjY54izw_kEg-J8LxKQnFy2Mo5nBL1Ez0aiaSa5IhrIj1AYfY4D-6RtK9KEuvdWHuvShLk2UznVl0ru_DT5RHvvJgI9HAOSY9g6CjtbBbKFzIeetO-_-p_8bgWOpAQ</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Boshier, Florencia A.T.</creator><creator>Venturini, Cristina</creator><creator>Stirrup, Oliver</creator><creator>Guerra-Assunção, José Afonso</creator><creator>Alcolea-Medina, Adela</creator><creator>Becket, Angela H.</creator><creator>Byott, Matthew</creator><creator>Charalampous, Themoula</creator><creator>Filipe, Ana da Silva</creator><creator>Frampton, Dan</creator><creator>Glaysher, Sharon</creator><creator>Khan, Tabassum</creator><creator>Kulasegara-Shylini, Raghavendran</creator><creator>Kele, Beatrix</creator><creator>Monahan, Irene M.</creator><creator>Mollett, Guy</creator><creator>Parker, Matthew</creator><creator>Pelosi, Emanuela</creator><creator>Randell, Paul</creator><creator>Roy, Sunando</creator><creator>Taylor, Joshua F.</creator><creator>Weller, Sophie J.</creator><creator>Wilson-Davies, Eleri</creator><creator>Wade, Phillip</creator><creator>Williams, Rachel</creator><creator>Copas, Andrew J.</creator><creator>Cutino-Moguel, Teresa</creator><creator>Freemantle, Nick</creator><creator>Hayward, Andrew C.</creator><creator>Holmes, Alison</creator><creator>Hughes, Joseph</creator><creator>Mahungu, Tabitha W.</creator><creator>Nebbia, Gaia</creator><creator>Nastouli, Eleni</creator><creator>Partridge, David G.</creator><creator>Pope, Cassie F.</creator><creator>Price, James R.</creator><creator>Robson, Samuel C.</creator><creator>Saeed, Kordo</creator><creator>Shin, Gee Yen</creator><creator>de Silva, Thushan I.</creator><creator>Snell, Luke B.</creator><creator>Thomson, Emma C.</creator><creator>Witney, Adam A.</creator><creator>Breuer, Judith</creator><general>Elsevier Ltd</general><general>W.B. 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We sought to determine whether this also resulted in increased transmission within hospitals.
We collected viral sequences and epidemiological data of patients with community and healthcare associated SARS-CoV-2 infections, sampled from 16th November 2020 to 10th January 2021, from nine hospitals participating in the COG-UK HOCI study. Outbreaks were identified using ward information, lineage and pairwise genetic differences between viral sequences.
Mixed effects logistic regression analysis of 4184 sequences showed healthcare-acquired infections were no more likely to be identified as the Alpha variant than community acquired infections. Nosocomial outbreaks were investigated based on overlapping ward stay and SARS-CoV-2 genome sequence similarity. There was no significant difference in the number of patients involved in outbreaks caused by the Alpha variant compared to outbreaks caused by other lineages.
We find no evidence to support it causing more nosocomial transmission than previous lineages. This suggests that the stringent infection prevention measures already in place in UK hospitals contained the spread of the Alpha variant as effectively as other less transmissible lineages, providing reassurance of their efficacy against emerging variants of concern.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34610391</pmid><doi>10.1016/j.jinf.2021.09.022</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4948-1004</orcidid><orcidid>https://orcid.org/0000-0002-4769-7912</orcidid><orcidid>https://orcid.org/0000-0002-8705-3281</orcidid><orcidid>https://orcid.org/0000-0002-8914-5868</orcidid><orcidid>https://orcid.org/0000-0002-4050-0064</orcidid><orcidid>https://orcid.org/0000-0003-4303-5716</orcidid><orcidid>https://orcid.org/0000-0003-2556-2563</orcidid><orcidid>https://orcid.org/0000-0001-8968-5963</orcidid><orcidid>https://orcid.org/0000-0003-2541-8545</orcidid><orcidid>https://orcid.org/0000-0002-6263-9497</orcidid><orcidid>https://orcid.org/0000-0002-6865-1948</orcidid><orcidid>https://orcid.org/0000-0002-3145-0376</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4453 |
| ispartof | The Journal of infection, 2021-12, Vol.83 (6), p.693-700 |
| issn | 0163-4453 1532-2742 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8487101 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alpha variant COVID-19 Cross Infection - epidemiology Hospitals Humans Lineage B.1.1.7 Nosocomial outbreaks SARS-CoV-2 Transmissibility United Kingdom - epidemiology Variants of concern |
| title | The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T02%3A47%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Alpha%20variant%20was%20not%20associated%20with%20excess%20nosocomial%20SARS-CoV-2%20infection%20in%20a%20multi-centre%20UK%20hospital%20study&rft.jtitle=The%20Journal%20of%20infection&rft.au=Boshier,%20Florencia%20A.T.&rft.aucorp=COG-UK%20HOCI%20Variant%20Substudy%20consortium,%20The%20COVID-19%20Genomics%20UK%20(COG-UK)%20consortium&rft.date=2021-12&rft.volume=83&rft.issue=6&rft.spage=693&rft.epage=700&rft.pages=693-700&rft.issn=0163-4453&rft.eissn=1532-2742&rft_id=info:doi/10.1016/j.jinf.2021.09.022&rft_dat=%3Cproquest_pubme%3E2579628390%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2579628390&rft_id=info:pmid/34610391&rft_els_id=S016344532100493X&rfr_iscdi=true |