Weight status and associated comorbidities in children and adults with Down syndrome, autism spectrum disorder and intellectual and developmental disabilities
Background Little is known about body weight status and the association between body weight and common comorbidities in children and adults with Down syndrome (DS), autism spectrum disorder (ASD) and other intellectual and developmental disabilities (IDDs). Methods Data were extracted from the Unive...
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| Veröffentlicht in: | Journal of intellectual disability research 2020-09, Vol.64 (9), p.725-737 |
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| container_title | Journal of intellectual disability research |
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| creator | Ptomey, L. T. Walpitage, D. L. Mohseni, M. Dreyer Gillette, M. L. Davis, A. M. Forseth, B. Dean, E. E. Waitman, L. R. |
| description | Background
Little is known about body weight status and the association between body weight and common comorbidities in children and adults with Down syndrome (DS), autism spectrum disorder (ASD) and other intellectual and developmental disabilities (IDDs).
Methods
Data were extracted from the University of Kansas Medical Center's Healthcare Enterprise Repository for Ontological Narration clinical integrated data repository. Measures included demographics (sex, age and race), disability diagnosis, comorbid health conditions, height, weight and body mass index percentiles (BMI%ile; |
| doi_str_mv | 10.1111/jir.12767 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8486319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2433174542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4207-75c811196d9b173eac457d5fd2b87646cfe5246bc1dcfe418c2bfda2ce241a063</originalsourceid><addsrcrecordid>eNp1kV1rFDEUhoModlu98B8EvFHotJOPSWZvBKlflYIgipchk5zpZskka5Lpsn_G32q6UwQFc5NwznPec05ehF6Q9oLUc7l16YJQKeQjtCJMdA2Vff8Yrdq14A0VjJ2g05y3bdsKwsVTdMKoJIKwfoV-_QB3uyk4F13mjHWwWOccjdMFLDZximlw1hUHGbuAzcZ5myAsoJ19yXjvyga_i_uA8yHYFCc4x3ouLk8478CUNE_YuhyThXSsc6GA9zUza38MWLgDH3cThFIjldWD88eez9CTUfsMzx_uM_T9w_tvV5-amy8fr6_e3jSG01Y2sjN9_Yi1sOuBSAba8E7abrR06KXgwozQUS4GQ2x9ctIbOoxWUwOUE90KdobeLLq7eZjAmjpJ0l7tkpt0Oqionfo7E9xG3cY71fNeMLKuAq8eBFL8OUMuanLZ1DV1gDhnRTmVHWVC3qMv_0G3cU6hrlcpxojkHaeVer1QJsWcE4x_hiGtunddVdfV0fXKXi7s3nk4_B9Un6-_LhW_ARD5sks</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2433174542</pqid></control><display><type>article</type><title>Weight status and associated comorbidities in children and adults with Down syndrome, autism spectrum disorder and intellectual and developmental disabilities</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Education Source</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ptomey, L. T. ; Walpitage, D. L. ; Mohseni, M. ; Dreyer Gillette, M. L. ; Davis, A. M. ; Forseth, B. ; Dean, E. E. ; Waitman, L. R.</creator><creatorcontrib>Ptomey, L. T. ; Walpitage, D. L. ; Mohseni, M. ; Dreyer Gillette, M. L. ; Davis, A. M. ; Forseth, B. ; Dean, E. E. ; Waitman, L. R.</creatorcontrib><description>Background
Little is known about body weight status and the association between body weight and common comorbidities in children and adults with Down syndrome (DS), autism spectrum disorder (ASD) and other intellectual and developmental disabilities (IDDs).
Methods
Data were extracted from the University of Kansas Medical Center's Healthcare Enterprise Repository for Ontological Narration clinical integrated data repository. Measures included demographics (sex, age and race), disability diagnosis, comorbid health conditions, height, weight and body mass index percentiles (BMI%ile; <18 years of age) or BMI (≥18 years of age).
Results
Four hundred and sixty‐eight individuals with DS (122 children and 346 adults), 1659 individuals with ASD (1073 children and 585 adults) and 604 individuals with other IDDs (152 children and 452 adults) were identified. A total of 47.0% (DS), 41.9% (ASD) and 33.5% (IDD) of children had overweight/obese (OW/OB), respectively. Children with DS were more likely to have OW/OB compared with children with IDD or ASD [odds ratio (OR) = 1.91, 95% confidence interval (CI): (1.49, 2.46); OR = 1.43, 95% CI: (1.19, 1.72)], respectively. A total of 81.1% (DS), 62.1% (ASD), and 62.4% (IDD) of adults were OW/OB, respectively. Adults with DS were more likely to have OW/OB compared with those with IDD [OR = 2.56, 95% CI: (2.16, 3.02)]. No significant differences were observed by race. In children with ASD, higher OW/OB was associated with significantly higher (compared with non‐OW/OB) occurrence of sleep apnoea [OR = 2.94, 95% CI: (2.22, 3.89)], hypothyroidism [OR = 3.14, 95% CI: (2.17, 4.25)] and hypertension [OR = 4.11, 95% CI: (3.05, 5.54)]. In adults with DS, OW/OB was significantly associated with higher risk of sleep apnoea and type 2 diabetes [OR = 2.93, 95% CI: (2.10, 4.09); OR = 1.76, 95% CI: (1.11, 2.79) respectively]. Similarly, in adults with ASD and IDD, OW/OB was significantly associated with higher risk of sleep apnoea [OR = 3.39, 95% CI: (2.37, 4.85) and OR = 6.69, 95% CI: (4.43, 10.10)], type 2 diabetes [OR = 2.25, 95 % CI: (1.68, 3.01) and OR = 5.49, 95% CI: (3.96, 7.61)] and hypertension [OR = 3.55, 95% CI: (2.76, 4.57) and 3.97, 95% CI: (3.17, 4.97)].
Conclusion
Findings suggest higher rates of OW/OB in individuals with DS compared with ASD and IDD. Given the increased risk of comorbidities associated with the increased risk of OW/OB, identification of effective interventions for this special population of individuals is critical.</description><identifier>ISSN: 0964-2633</identifier><identifier>EISSN: 1365-2788</identifier><identifier>DOI: 10.1111/jir.12767</identifier><identifier>PMID: 32716138</identifier><language>eng</language><publisher>Oxford: Wiley Subscription Services, Inc</publisher><subject>Adults ; Age ; Autism ; Autism Spectrum Disorders ; Autistic children ; Body Composition ; Body mass index ; Body weight ; Childhood obesity ; children ; Comorbidity ; Developmental disabilities ; Diabetes ; disabilities ; Down syndrome ; Health care ; Hypertension ; Hypothyroidism ; Intellectual disabilities ; Intellectual Disability ; Medical diagnosis ; Narration ; obesity ; Race ; Racial differences ; Scientific Concepts ; Sleep apnea ; Type 2 diabetes mellitus ; weight</subject><ispartof>Journal of intellectual disability research, 2020-09, Vol.64 (9), p.725-737</ispartof><rights>2020 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4207-75c811196d9b173eac457d5fd2b87646cfe5246bc1dcfe418c2bfda2ce241a063</citedby><cites>FETCH-LOGICAL-c4207-75c811196d9b173eac457d5fd2b87646cfe5246bc1dcfe418c2bfda2ce241a063</cites><orcidid>0000-0002-1705-1643</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjir.12767$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjir.12767$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,30976,45550,45551</link.rule.ids></links><search><creatorcontrib>Ptomey, L. T.</creatorcontrib><creatorcontrib>Walpitage, D. L.</creatorcontrib><creatorcontrib>Mohseni, M.</creatorcontrib><creatorcontrib>Dreyer Gillette, M. L.</creatorcontrib><creatorcontrib>Davis, A. M.</creatorcontrib><creatorcontrib>Forseth, B.</creatorcontrib><creatorcontrib>Dean, E. E.</creatorcontrib><creatorcontrib>Waitman, L. R.</creatorcontrib><title>Weight status and associated comorbidities in children and adults with Down syndrome, autism spectrum disorder and intellectual and developmental disabilities</title><title>Journal of intellectual disability research</title><description>Background
Little is known about body weight status and the association between body weight and common comorbidities in children and adults with Down syndrome (DS), autism spectrum disorder (ASD) and other intellectual and developmental disabilities (IDDs).
Methods
Data were extracted from the University of Kansas Medical Center's Healthcare Enterprise Repository for Ontological Narration clinical integrated data repository. Measures included demographics (sex, age and race), disability diagnosis, comorbid health conditions, height, weight and body mass index percentiles (BMI%ile; <18 years of age) or BMI (≥18 years of age).
Results
Four hundred and sixty‐eight individuals with DS (122 children and 346 adults), 1659 individuals with ASD (1073 children and 585 adults) and 604 individuals with other IDDs (152 children and 452 adults) were identified. A total of 47.0% (DS), 41.9% (ASD) and 33.5% (IDD) of children had overweight/obese (OW/OB), respectively. Children with DS were more likely to have OW/OB compared with children with IDD or ASD [odds ratio (OR) = 1.91, 95% confidence interval (CI): (1.49, 2.46); OR = 1.43, 95% CI: (1.19, 1.72)], respectively. A total of 81.1% (DS), 62.1% (ASD), and 62.4% (IDD) of adults were OW/OB, respectively. Adults with DS were more likely to have OW/OB compared with those with IDD [OR = 2.56, 95% CI: (2.16, 3.02)]. No significant differences were observed by race. In children with ASD, higher OW/OB was associated with significantly higher (compared with non‐OW/OB) occurrence of sleep apnoea [OR = 2.94, 95% CI: (2.22, 3.89)], hypothyroidism [OR = 3.14, 95% CI: (2.17, 4.25)] and hypertension [OR = 4.11, 95% CI: (3.05, 5.54)]. In adults with DS, OW/OB was significantly associated with higher risk of sleep apnoea and type 2 diabetes [OR = 2.93, 95% CI: (2.10, 4.09); OR = 1.76, 95% CI: (1.11, 2.79) respectively]. Similarly, in adults with ASD and IDD, OW/OB was significantly associated with higher risk of sleep apnoea [OR = 3.39, 95% CI: (2.37, 4.85) and OR = 6.69, 95% CI: (4.43, 10.10)], type 2 diabetes [OR = 2.25, 95 % CI: (1.68, 3.01) and OR = 5.49, 95% CI: (3.96, 7.61)] and hypertension [OR = 3.55, 95% CI: (2.76, 4.57) and 3.97, 95% CI: (3.17, 4.97)].
Conclusion
Findings suggest higher rates of OW/OB in individuals with DS compared with ASD and IDD. Given the increased risk of comorbidities associated with the increased risk of OW/OB, identification of effective interventions for this special population of individuals is critical.</description><subject>Adults</subject><subject>Age</subject><subject>Autism</subject><subject>Autism Spectrum Disorders</subject><subject>Autistic children</subject><subject>Body Composition</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Childhood obesity</subject><subject>children</subject><subject>Comorbidity</subject><subject>Developmental disabilities</subject><subject>Diabetes</subject><subject>disabilities</subject><subject>Down syndrome</subject><subject>Health care</subject><subject>Hypertension</subject><subject>Hypothyroidism</subject><subject>Intellectual disabilities</subject><subject>Intellectual Disability</subject><subject>Medical diagnosis</subject><subject>Narration</subject><subject>obesity</subject><subject>Race</subject><subject>Racial differences</subject><subject>Scientific Concepts</subject><subject>Sleep apnea</subject><subject>Type 2 diabetes mellitus</subject><subject>weight</subject><issn>0964-2633</issn><issn>1365-2788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNp1kV1rFDEUhoModlu98B8EvFHotJOPSWZvBKlflYIgipchk5zpZskka5Lpsn_G32q6UwQFc5NwznPec05ehF6Q9oLUc7l16YJQKeQjtCJMdA2Vff8Yrdq14A0VjJ2g05y3bdsKwsVTdMKoJIKwfoV-_QB3uyk4F13mjHWwWOccjdMFLDZximlw1hUHGbuAzcZ5myAsoJ19yXjvyga_i_uA8yHYFCc4x3ouLk8478CUNE_YuhyThXSsc6GA9zUza38MWLgDH3cThFIjldWD88eez9CTUfsMzx_uM_T9w_tvV5-amy8fr6_e3jSG01Y2sjN9_Yi1sOuBSAba8E7abrR06KXgwozQUS4GQ2x9ctIbOoxWUwOUE90KdobeLLq7eZjAmjpJ0l7tkpt0Oqionfo7E9xG3cY71fNeMLKuAq8eBFL8OUMuanLZ1DV1gDhnRTmVHWVC3qMv_0G3cU6hrlcpxojkHaeVer1QJsWcE4x_hiGtunddVdfV0fXKXi7s3nk4_B9Un6-_LhW_ARD5sks</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Ptomey, L. T.</creator><creator>Walpitage, D. L.</creator><creator>Mohseni, M.</creator><creator>Dreyer Gillette, M. L.</creator><creator>Davis, A. M.</creator><creator>Forseth, B.</creator><creator>Dean, E. E.</creator><creator>Waitman, L. R.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1705-1643</orcidid></search><sort><creationdate>202009</creationdate><title>Weight status and associated comorbidities in children and adults with Down syndrome, autism spectrum disorder and intellectual and developmental disabilities</title><author>Ptomey, L. T. ; Walpitage, D. L. ; Mohseni, M. ; Dreyer Gillette, M. L. ; Davis, A. M. ; Forseth, B. ; Dean, E. E. ; Waitman, L. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4207-75c811196d9b173eac457d5fd2b87646cfe5246bc1dcfe418c2bfda2ce241a063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adults</topic><topic>Age</topic><topic>Autism</topic><topic>Autism Spectrum Disorders</topic><topic>Autistic children</topic><topic>Body Composition</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Childhood obesity</topic><topic>children</topic><topic>Comorbidity</topic><topic>Developmental disabilities</topic><topic>Diabetes</topic><topic>disabilities</topic><topic>Down syndrome</topic><topic>Health care</topic><topic>Hypertension</topic><topic>Hypothyroidism</topic><topic>Intellectual disabilities</topic><topic>Intellectual Disability</topic><topic>Medical diagnosis</topic><topic>Narration</topic><topic>obesity</topic><topic>Race</topic><topic>Racial differences</topic><topic>Scientific Concepts</topic><topic>Sleep apnea</topic><topic>Type 2 diabetes mellitus</topic><topic>weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ptomey, L. T.</creatorcontrib><creatorcontrib>Walpitage, D. L.</creatorcontrib><creatorcontrib>Mohseni, M.</creatorcontrib><creatorcontrib>Dreyer Gillette, M. L.</creatorcontrib><creatorcontrib>Davis, A. M.</creatorcontrib><creatorcontrib>Forseth, B.</creatorcontrib><creatorcontrib>Dean, E. E.</creatorcontrib><creatorcontrib>Waitman, L. R.</creatorcontrib><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of intellectual disability research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ptomey, L. T.</au><au>Walpitage, D. L.</au><au>Mohseni, M.</au><au>Dreyer Gillette, M. L.</au><au>Davis, A. M.</au><au>Forseth, B.</au><au>Dean, E. E.</au><au>Waitman, L. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Weight status and associated comorbidities in children and adults with Down syndrome, autism spectrum disorder and intellectual and developmental disabilities</atitle><jtitle>Journal of intellectual disability research</jtitle><date>2020-09</date><risdate>2020</risdate><volume>64</volume><issue>9</issue><spage>725</spage><epage>737</epage><pages>725-737</pages><issn>0964-2633</issn><eissn>1365-2788</eissn><abstract>Background
Little is known about body weight status and the association between body weight and common comorbidities in children and adults with Down syndrome (DS), autism spectrum disorder (ASD) and other intellectual and developmental disabilities (IDDs).
Methods
Data were extracted from the University of Kansas Medical Center's Healthcare Enterprise Repository for Ontological Narration clinical integrated data repository. Measures included demographics (sex, age and race), disability diagnosis, comorbid health conditions, height, weight and body mass index percentiles (BMI%ile; <18 years of age) or BMI (≥18 years of age).
Results
Four hundred and sixty‐eight individuals with DS (122 children and 346 adults), 1659 individuals with ASD (1073 children and 585 adults) and 604 individuals with other IDDs (152 children and 452 adults) were identified. A total of 47.0% (DS), 41.9% (ASD) and 33.5% (IDD) of children had overweight/obese (OW/OB), respectively. Children with DS were more likely to have OW/OB compared with children with IDD or ASD [odds ratio (OR) = 1.91, 95% confidence interval (CI): (1.49, 2.46); OR = 1.43, 95% CI: (1.19, 1.72)], respectively. A total of 81.1% (DS), 62.1% (ASD), and 62.4% (IDD) of adults were OW/OB, respectively. Adults with DS were more likely to have OW/OB compared with those with IDD [OR = 2.56, 95% CI: (2.16, 3.02)]. No significant differences were observed by race. In children with ASD, higher OW/OB was associated with significantly higher (compared with non‐OW/OB) occurrence of sleep apnoea [OR = 2.94, 95% CI: (2.22, 3.89)], hypothyroidism [OR = 3.14, 95% CI: (2.17, 4.25)] and hypertension [OR = 4.11, 95% CI: (3.05, 5.54)]. In adults with DS, OW/OB was significantly associated with higher risk of sleep apnoea and type 2 diabetes [OR = 2.93, 95% CI: (2.10, 4.09); OR = 1.76, 95% CI: (1.11, 2.79) respectively]. Similarly, in adults with ASD and IDD, OW/OB was significantly associated with higher risk of sleep apnoea [OR = 3.39, 95% CI: (2.37, 4.85) and OR = 6.69, 95% CI: (4.43, 10.10)], type 2 diabetes [OR = 2.25, 95 % CI: (1.68, 3.01) and OR = 5.49, 95% CI: (3.96, 7.61)] and hypertension [OR = 3.55, 95% CI: (2.76, 4.57) and 3.97, 95% CI: (3.17, 4.97)].
Conclusion
Findings suggest higher rates of OW/OB in individuals with DS compared with ASD and IDD. Given the increased risk of comorbidities associated with the increased risk of OW/OB, identification of effective interventions for this special population of individuals is critical.</abstract><cop>Oxford</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32716138</pmid><doi>10.1111/jir.12767</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-1705-1643</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Education Source; Wiley Online Library Journals Frontfile Complete |
| subjects | Adults Age Autism Autism Spectrum Disorders Autistic children Body Composition Body mass index Body weight Childhood obesity children Comorbidity Developmental disabilities Diabetes disabilities Down syndrome Health care Hypertension Hypothyroidism Intellectual disabilities Intellectual Disability Medical diagnosis Narration obesity Race Racial differences Scientific Concepts Sleep apnea Type 2 diabetes mellitus weight |
| title | Weight status and associated comorbidities in children and adults with Down syndrome, autism spectrum disorder and intellectual and developmental disabilities |
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