Impact of hypoxia on the pathogenesis and therapy resistance in multiple myeloma

Multiple myeloma (MM) is a refractory plasma cell tumor. In myeloma cells, the transcription factor IRF4, the master regulator of plasma cells, is aberrantly upregulated and plays an essential role in oncogenesis. IRF4 forms a positive feedback loop with MYC, leading to additional tumorigenic proper...

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Veröffentlicht in:	Cancer science 2021-10, Vol.112 (10), p.3995-4004
Hauptverfasser:	Ikeda, Sho, Tagawa, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Antigens Apoptosis Bone marrow Cancer therapies Cell cycle Drug resistance Feedback Gene expression Genotype & phenotype HIF Homeostasis Hypoxia Interferon regulatory factor 4 IRF4 Medical prognosis Metabolism Microenvironments Multiple myeloma MYC Myc protein Plasma Plasma cells Population Proteins Regulation Remission Review Stem cells Transcription factors Tumorigenesis Tumors
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